FMRI IN BIPOLAR ILLNESS

FMRI 在双相情感障碍中的应用

• 批准号: 7955623
• 负责人: LORI L ALTSHULER
• 金额: $ 1.32万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955623
• 关键词: Amygdaloid structure; Anterior; Area; Blood flow; Brain; Brain Mapping; Computer Retrieval of Information on Scientific Projects Database; Functional Magnetic Resonance Imaging; Funding; Grant; Institution; Lateral; Manic; Mental disorders; Modeling; Moods; Positron-Emission Tomography; Psychiatry; Research; Research Personnel; Research Project Grants; Resources; Signal Transduction; Source; Technology; Training; United States National Institutes of Health; Work; computational anatomy; depression; frontal lobe; neuroimaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The applicant proposes to acquire training in functional neuroimaging technology, including fMRI and PET. This will expand her expertise in neuroimaging and psychiatry from the structural realm into the functional neuroanatomic domain, and further her research endeavors in attempting to understand the neuroanatomic underpinnings of psychiatric disorders. The applicant proposes to work extensively with the Brain Mapping Division at UCLA and proposes an fMRI research project to explore brain changes that occur with mood changes in mania and depression. She will look for blood flow changes that occur in the amygdala and frontal lobe as a function of changing mood state. Specifically, she will assess fMRI signal activation in the amygdala and frontal cortex (anterior cingulate, orbitofrontal and lateral prefrontal areas) in bipolar subjects as they go from either mania to euthymia or depression to euthymia.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 申请人建议接受功能神经影像技术的培训，包括功能磁共振成像和正电子断层扫描。这将使她在神经影像学和精神病学方面的专业知识从结构领域扩展到功能性神经解剖学领域，并进一步推动她的研究努力，试图了解精神疾病的神经解剖学基础。申请人提议与加州大学洛杉矶分校的大脑绘图部门广泛合作，并提出一个功能磁共振成像研究项目，以探索躁狂和抑郁情绪变化引起的大脑变化。她将寻找杏仁核和额叶中发生的血流变化，作为情绪状态变化的函数。具体来说，她将评估双相情感障碍受试者从躁狂到正常或抑郁到正常的杏仁核和额叶皮层（前扣带回、眶额叶和外侧前额叶区域）的功能磁共振成像信号激活情况。