CSHL 2020 Protein Homeostasis in Health and Disease

CSHL 2020 健康和疾病中的蛋白质稳态

基本信息

批准号：
9913842
负责人：
DAVID J. STEWART
金额：
$ 3.09万
依托单位：
COLD SPRING HARBOR LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-01-01 至 2020-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9913842
关键词：
3-Dimensional Address Affect Age Aging Alzheimer&apos s Disease Amino Acids Amyloidosis Animal Model Area Attention Basic Science Binding Biochemical Biogenesis Biology Biomedical Research Biophysics Businesses Cell Compartmentation Cell physiology Cells Cellular Stress Client Communicable Diseases Communities Complement Complex Data Development Diabetes Mellitus Discipline Disease Ensure Environment Equilibrium Explosion Faculty Failure Feedback Financial Support Fire - disasters Fostering Future General Population Goals Health Heart Heart Diseases Heat shock proteins Heat-Shock Response Homeostasis Huntington Disease In Vitro Industry International Journals Knowledge Laboratories Malignant Neoplasms Measures Medicine Metabolic Diseases Metabolism Methods Molecular Molecular Chaperones Nerve Degeneration Neurodegenerative Disorders Oral Organism Parkinson Disease Participant Pathway interactions Phase Transition Physiology Polymers Postdoctoral Fellow Prion Diseases Process Protein Biosynthesis Protein Conformation Proteins Publishing Quality Control Questionnaires Recording of previous events Research Institute Research Personnel Ribosomes Role Schedule Science Scientist Signal Transduction Slide Stress Therapeutic Thinking Time Toxic effect Translating Woman Work age effect age related arm biological adaptation to stress cell type disorder risk graduate student healthy aging hormonal signals in vivo insight interest lectures macromolecular assembly meetings novel polypeptide posters protein aggregation protein degradation protein folding protein function protein misfolding proteostasis repaired response stress granule success symposium tumor metabolism virtual

项目摘要

Cold Spring Harbor Laboratory Conference on Protein Homeostasis in Health and Disease April 21 – 25, 2020 ABSTRACT This proposal is a request for financial support for a meeting on PROTEIN HOMEOSTASIS IN HEALTH AND DISEASE to be held at Cold Spring Harbor Laboratory from April 21 – 25, 2020. This meeting is the premier international forum for presentation of new results in this area, and is attended by representatives from virtually every major laboratory in the field. The explosion of new information on how the folded state of proteins is acquired and maintained in vivo and the relevance of this process to healthy aging and risk for diseases of neurodegeneration, cancer, and metabolism guarantees an excitement and urgency of this meeting. Because of the recent developments on stress signaling in aging and disease, we will open the meeting with this new session followed the next day with a session on protein aggregation in aging and neurodegenerative diseases and then closing the meeting with a session on correcting proteostasis in aging and disease. Additional sessions will address the relationship between protein synthesis, folding, translocation and degradation by discussing the molecular mechanisms of chaperone function, degradative mechanisms and on spatial quality control and organellar proteostasis. The meeting will also introduce another new session on stress granules and phase transitions that has brought many new concepts on stress physiology, regulatory biology and novel forms of macromolecular interaction. These fundamental questions are at the heart of biology of proteostasis that will be complemented by the sessions on aging and proteostasis failure in diseases of protein misfolding including Alzheimer's disease, ALS, Parkinson's disease and Huntington's disease. The themes of aging, proteostasis failure, and diseases of protein misfolding are well integrated throughout the meeting, and emerging principles on protein client interactions and alternate protein conformations will be predominantly displayed. The diverse protein quality control strategies used by compartments of the cell to ensure the integrity of the secretory and organellar pathways during times of protein folding stress will be represented by emerging topics on spatial quality control within a cell. The field of heat shock proteins and molecular chaperones has grown exponentially and draws interest not only from traditional scientific disciplines in the basic sciences but also from diverse areas of biomedical research including neurodegenerative disease, infectious diseases, cancer, heart disease and aging. The meeting will have eight lecture sessions, two poster sessions, two rapid-fire presentation sessions, and a panel discussion on scientific publishing. The sessions include: 1) Integrative stress signaling in aging and disease, 2) Chaperone mechanisms I, 3) Protein aggregation in aging and neurodegenerative diseases, 4) Clearance mechanisms, 5) Chaperone mechanisms II, 6) Stress granules and phase transitions, 7) Organellar proteostasis and spatial quality control, and 8) Correcting proteostasis in aging and disease. Each session will consist of eight to nine oral presentations and will be chaired by an invited speaker. Generally, two speakers will be pre-invited per session with the remainder to be selected from submitted abstracts, thus ~60-65% of speakers will be from submitted abstracts to ensure balance of junior investigators, women and all forms of diversity. As well, we will have two rapid fire sessions, each with ten-2 min. talks to increase the visibility from the poster sessions. This balance of talks allows the meeting to feature presentations by leading scientists, to be responsive to exciting new developments, and to encourage diverse participation that recognizes new investigators.

冷泉港实验室会议健康和疾病中的蛋白质稳态 2020 年 4 月 21 日至 25 日抽象的该提案是为蛋白质稳态会议提供财政支持的请求健康与疾病将于 2020 年 4 月 21 日至 25 日在冷泉港实验室举行。这次会议是展示该领域新成果的首要国际论坛，几乎该领域每个主要实验室的代表都出席了会议。关于蛋白质折叠状态如何在体内获得和维持的新信息以及这一过程与健康老龄化和神经退行性疾病、癌症、由于最近，新陈代谢保证了这次会议的兴奋和紧迫性。关于衰老和疾病中的压力信号，我们将用这个新的第二天的会议是关于衰老和蛋白质聚集的会议神经退行性疾病，然后以纠正问题的会议结束会议其他会议将讨论衰老和疾病之间的关系。通过讨论分子结构来了解蛋白质的合成、折叠、易位和降解伴侣功能机制、降解机制以及空间质量控制和会议还将介绍另一个关于压力的新会议。颗粒和相变带来了许多关于应激生理学的新概念，这些基本问题是调控生物学和大分子相互作用的新形式。是蛋白质稳态生物学的核心，衰老会议将对其进行补充以及蛋白质错误折叠疾病中的蛋白质稳态失败，包括阿尔茨海默病、ALS、帕金森氏病和亨廷顿氏病的主题是衰老、蛋白质稳态失败和蛋白质错误折叠疾病在整个会议中得到了很好的整合，并且正在出现蛋白质客户相互作用和替代蛋白质构象的原则将是主要展示了隔室使用的多种蛋白质质量控制策略。细胞以确保分泌和细胞器途径的完整性蛋白质折叠应力将以空间质量控制的新兴主题为代表热休克蛋白和分子伴侣领域呈指数增长。不仅引起了基础科学中传统科学学科的兴趣，而且引起了人们的兴趣生物医学研究的各个领域，包括神经退行性疾病、传染病、会议将有八场讲座、两张海报。会议、两次快速演示会议以及关于科学出版的小组讨论。会议内容包括：1) 衰老和疾病中的综合压力信号传导，2) 伴侣机制 I, 3) 衰老和神经退行性疾病中的蛋白质聚集，4) 清除机制，5) 陪伴机制 II，6) 应力颗粒和相变，7) 细胞器蛋白质稳态和空间质量控制，以及 8) 纠正衰老和衰老过程中的蛋白质稳态每场会议将包括八到九次口头报告，并由一名主席主持。一般情况下，每场会议将预先邀请两名发言人，其余则待邀请。从提交的摘要中选出，因此约 60-65% 的演讲者将来自提交的摘要确保初级调查员、女性和各种形式多样性的平衡。两次快速会议，每次有 10 到 2 分钟的演讲，以提高海报的可见度。这种会议的平衡使得会议能够以领导者的方式进行演讲。科学家，对令人兴奋的新发展做出反应，并鼓励多样化认可新研究者的参与。