Novel Implementation of Microporous Annealed Particle HydroGel for Next-generation Posterior Pharyngeal Wall Augmentation

用于下一代咽后壁增强的微孔退火颗粒水凝胶的新实现

• 批准号: 10727361
• 负责人: James J. Daniero
• 金额: $ 32.3万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10727361
• 关键词: 3-Dimensional; Acute; Address; Advanced Development; Aerodigestive Tract; Affect; Aftercare; Anatomy; Animal Model; Biocompatible Materials; Biomedical Engineering; Blood Vessels; Calcium; Clinical; Collaborations; Collagen; Data; Dermis; Detection; Durapatite; Environment; Failure; Filler; Foreign-Body Reaction; Fostering; Functional disorder; Future; Gel; Goals; Growth; Hyaluronic Acid; Hydrogels; Immune; Implant; In Situ; Inflammation; Injectable; Injections; Light; Magnetic Resonance Imaging; Methodology; Methods; Microspheres; Modeling; Modernization; Molecular Conformation; Movement; Muscle; Operative Surgical Procedures; Oryctolagus cuniculus; Otolaryngology; Outcome; Outcome Assessment; Patients; Pharyngeal structure; Physiology; Plastic Surgical Procedures; Porosity; Pre-Clinical Model; Procedures; Reporting; Research Personnel; Scientific Advances and Accomplishments; Second Look Surgery; Speech; Speech Disorders; Stains; Surgical Management; Technology; Time; Tissue Stains; Tissues; Vascularization; Visualization software; Voice Disorders; absorption; care burden; clinical application; craniofacial; early childhood; imaging science; immunogenicity; implantation; improved; in vivo; inflammatory marker; innovation; manufacture; migration; minimally invasive; next generation; novel; particle; precision medicine; preclinical development; reconstruction; respiratory morbidity; retention rate; success; tissue regeneration

Synthetic hydrogels offer a promising platform for volumetric augmentation of the aerodigestive tract for precision medicine approaches. We propose that an ideal biomaterial platform for PPW augmentation to treat VPD would provide a durable tissue bulking effect, maintain implant configuration, and avoid FBR within a dynamic tissue environment. Specifically, Microporous Annealed Particle (MAP) hydrogels are an ideal material platform for the minimally invasive treatment of VPD. This novel biomaterial is a promising scientific advancement that has implications for improving VPD in patients with cleft and craniofacial conditions, particularly related to pharyngeal wall augmentation for managing VPD. There is a pressing need to utilize novel biomaterials and minimally invasive approaches to improve long-term outcomes for managing and resolving VPD. To address this need, we have developed a novel iteration of MAP hydrogel that is optimized for muscle implantation, tolerates dynamic movement, promotes excellent tissue integration, and provides persistent tissue bulk via 1:1 volume replacement with tissue de novo. Application of this unique biomaterial for PPW augmentation in an animal model will allow for novel analyses and new clinical applications for the MAP hydrogel. This proposal specifically aims to (1) quantify changes in pharyngeal wall anatomy in a rabbit model after pharyngeal wall augmentation and (2) identify the host-implant microenvironment required to achieve in situ tissue regeneration following optimized MAP gel pharyngeal wall augmentation.

合成水凝胶为呼吸消化系统的体积增加提供了一个有前景的平台 精准医学方法小册子。我们提出了一个理想的 PPW 生物材料平台 治疗 VPD 的增强术将提供持久的组织膨胀效果，维持植入物 配置，并避免动态组织环境中的 FBR。具体来说，微孔 退火颗粒（MAP）水凝胶是微创治疗的理想材料平台 VPD 的治疗。这种新型生物材料是一项有前途的科学进步 对改善唇裂和颅面疾病患者的 VPD 的影响，特别是 与用于治疗 VPD 的咽壁增强相关。迫切需要利用 新型生物材料和微创方法可改善长期结果 管理和解决 VPD。为了满足这一需求，我们开发了一种新颖的 MAP 迭代 针对肌肉植入进行了优化的水凝胶，可耐受动态运动，促进 出色的组织整合，并通过 1:1 体积替换提供持久的组织体积 从头组织。这种独特的生物材料在动物模型中用于增强 PPW 的应用 将允许对 MAP 水凝胶进行新颖的分析和新的临床应用。这个提议 具体目的是（1）量化兔模型咽壁解剖结构的变化 咽壁增强和（2）确定所需的宿主植入物微环境 在优化 MAP 凝胶咽壁增强后实现原位组织再生。