CSHL 2016 Glia in Health & Disease Conference

CSHL 2016 神经胶质细胞健康

• 批准号: 9051547
• 负责人: DAVID J. STEWART
• 金额: $ 2.93万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9051547
• 关键词: Action Potentials; Advanced Development; Amyotrophic Lateral Sclerosis; Area; Axon; Behavior; Biochemistry; Biological Models; Biology; Brain; Cell physiology; Cells; Cicatrix; Communities; Data; Development; Disease; Energy-Generating Resources; Ensure; Environment; Equilibrium; Event; Exposure to; Faculty; Fostering; Functional disorder; Future; Gene Mutation; Genetic; Goals; Health; Huntington Disease; Image; Imagery; Injury; International; Invertebrates; Ions; Laboratories; Lead; Length of Stay; Link; Metabolic; Methodology; Minority; Molecular; Molecular Biology; Molecular Genetics; Mutation; Natural regeneration; Nerve Regeneration; Nervous System Physiology; Nervous system structure; Neurodegenerative Disorders; Neuroglia; Neuromodulator; Neurons; Neurotransmitter Receptor; Neurotransmitters; Oral; Participant; Physiology; Play; Postdoctoral Fellow; Research; Research Institute; Research Personnel; Resolution; Resource Development; Role; Schedule; Scientist; Series; Signal Transduction; Structure; Synaptic plasticity; Trauma; Woman; Work; abstracting; base; cost; extracellular; genetic manipulation; graduate student; human disease; in vivo imaging; interest; laboratory facility; meetings; member; nervous system development; nervous system disorder; neural circuit; new therapeutic target; notch protein; novel strategies; novel therapeutic intervention; novel therapeutics; posters; public health relevance; relating to nervous system; repaired; success; symposium; therapeutic development; tool; transmission process; unpublished works

 DESCRIPTION (provided by applicant): The proposed meeting on Glia in Health & Disease will be held at Cold Spring Harbor Laboratory from July 21-25 2016. The goal of this conference is to provide an active forum for exchange of results in the rapidly advancing fields of glial biology and neuron-glia interactions. Glial cells comprise a diverse group of non-neuronal cells that are essential for nervous system development, circuit function, and neurological disease. These cells perform many supportive roles, such as controlling extracellular ion and neurotransmitter levels, providing neurons with energy sources, and unsheathing axons to enable rapid transmission of action potentials with minimal metabolic cost. The development of advanced genetic tools is beginning to define the molecular events that establish and maintain these crucial interactions, providing new targets for therapeutic manipulation. In addition, recent studies suggest that glial cells can play a much more active role in modulating the function of neural circuits; glial cells express receptors for neurotransmitters and can release retroactive compounds that influence neural firing and synaptic plasticity. Nevertheless, the conditions required to activate different types of glial cells and induce the release of neuromodulators are not well understood. Glia also help the CNS recover from injury and disease by forming glial scars, by engulfing dying neurons and debris, and by regenerating lost cells. However, glia can undergo reactive changes that compromise their ability to adequately support neurons, or in some cases promote further destruction. The mechanisms that control these changes and the consequences of their altered behavior in disease and injury are just beginning to be defined. It has become clear that many gene mutations linked to neurodegenerative diseases, such as Huntington's disease and amyotrophic lateral sclerosis (ALS), are also expressed in glia, and genetic manipulation studies are beginning to reveal how these mutations alter glial cell function and contribute to disease. This meeting will highlight the latest developments obtained through studies of both invertebrate and vertebrate model systems and provide exposure to technological advances in genetics, molecular biology, biochemistry, physiology, and high-resolution imaging. Using the goals and format of the five prior extremely successful meetings as a guide, we plan to 1) assemble an international meeting of scientists engaged in studies of glial biology and neuron-glia interactions; 2) discuss new and exciting developments in the field by selecting talks from openly submitted abstracts on the basis of scientific merit; 3) provide an opportunity for junior scientists of diverse backgrounds to present their data and engage in scientific discourse with more established investigators; and 4) promote collaborative interactions to accelerate the pace of discovery and identify novel approaches to treat diseases of the nervous system.

 描述（由申请人提供）：拟议的关于健康与疾病中的神经胶质细胞的会议将于 2016 年 7 月 21 日至 25 日在冷泉港实验室举行。本次会议的目标是提供一个活跃的论坛，以便在快速发展的领域交流成果神经胶质细胞由多种非神经元细胞组成，这些细胞对于神经系统发育、回路功能和神经系统疾病至关重要。细胞外离子和神经递质水平，为神经元提供能量来源，并释放轴突，以最小的代谢成本实现动作电位的快速传递。先进遗传工具的开发开始定义建立和维持这些关键相互作用的分子事件，提供新的。此外，最近的治疗操作目标。 研究表明，神经胶质细胞在调节神经回路功能方面可以发挥更积极的作用；神经胶质细胞表达神经递质受体，并可以释放影响神经放电和突触可塑性的追溯化合物。神经胶质细胞还可以通过形成神经胶质疤痕、吞噬垂死的神经元和碎片以及再生丢失的细胞来帮助中枢神经系统从损伤和疾病中恢复。然而，神经胶质细胞可能会发生反应性变化，从而损害其充分支持神经元的能力，或者在某些情况下促进进一步破坏。控制这些变化及其在疾病和损伤中行为改变的后果的机制才刚刚开始被确定。很明显，许多与神经退行性疾病相关的基因突变，如亨廷顿病和肌萎缩侧索硬化症（ALS），也在神经胶质细胞中表达，基因操作研究开始揭示这些突变如何改变神经胶质细胞功能并导致疾病.本次会议将重点介绍通过无脊椎动物和脊椎动物模型系统研究获得的最新进展，并利用之前五次极其成功的会议的目标和形式，介绍遗传学、分子生物学、生物化学、生理学和高分辨率成像方面的技术进步。作为指南，我们计划 1) 召开一次由从事神经胶质生物学和神经元-神经胶质相互作用研究的科学家组成的国际会议；2) 通过从公开提交的摘要中选择基于科学的演讲来讨论该领域的新的、令人兴奋的进展；优点；3）为不同背景的年轻科学家提供展示数据并与更成熟的研究人员进行科学讨论的机会；4）促进合作互动，以加快发现速度并确定治疗神经系统疾病的新方法。