CSHL 2022 Glia in Health & Disease Conference

CSHL 2022 神经胶质细胞健康

基本信息

批准号：
10387663
负责人：
DAVID J. STEWART
金额：
$ 2.3万
依托单位：
COLD SPRING HARBOR LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-15 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10387663
关键词：
Action Potentials Advanced Development Aging Alzheimer&apos s Disease Area Axon Behavior Biochemistry Biological Models Biology Blood Vessels Blood flow Brain Cell physiology Cells Cellular biology Chronic Cicatrix Communities Data Development Disease Ensure Environment Etiology Faculty Fostering Functional disorder Future Gene Mutation Genes Genetic Goals Health Human Image Imaging technology Industry Inflammation Inflammatory Injury International Invertebrates Laboratories Lead Length of Stay Link Metabolic Methodology Minority Molecular Molecular Biology Molecular Genetics Multiple Sclerosis Mutation Natural regeneration Nerve Regeneration Nervous System Physiology Neurodegenerative Disorders Neuroglia Neurons Neurophysiology - biologic function Neurotransmitters Oral Participant Physiology Play Postdoctoral Fellow Research Research Institute Research Personnel Role Schedule Scientist Series Signal Transduction Synapses Synaptic plasticity System Woman Work base genetic manipulation graduate student human disease human tissue imaging approach interest laboratory facility meetings member nervous system development nervous system disorder neural circuit new therapeutic target notch protein novel strategies novel therapeutic intervention novel therapeutics posters relating to nervous system repaired success symposium therapeutic target tissue repair tool unpublished works virtual

项目摘要

2022 Cold Spring Harbor Laboratory Conference GLIA IN HEALTH & DISEASE Abstract The proposed meeting on Glia in Health & Disease will be held at Cold Spring Harbor Laboratory from July 21 – 25, 2022. The goal of this conference is to provide an active forum for exchange of results in the rapidly advancing fields of glial biology and neuron-glia interactions. Glial cells comprise a diverse group of non-neuronal cells that are essential for nervous system development, circuit function, and neurological disease. These cells perform many important roles, such as sculpting developing circuits, regulating neurotransmitter signaling between neurons, providing metabolic support to neurons and other glial cells, supporting the fast and efficient propagation of action potentials, modulating vascular development and blood flow, and regulating inflammatory cascades in disease. With the advancement of genetic tools to specifically target glia, we are now gaining a deeper mechanistic understanding of these and other glial cell functions in health and disease. This includes a new realization that glia actively modulate neural circuit function, plasticity, and behavior under healthy, steady-state conditions. We are also now appreciating how these functions go awry in disease, leading to circuit dysfunction, chronic inflammation, and destruction of neurons and their synaptic connections. There are also clear indications that glia may not only react to diseased neurons to propagate disease, but they are a part of the underlying etiology. For example, many gene mutations linked to neurodegenerative diseases, such as Alzheimer's disease and multiple sclerosis (MS), are in genes enriched in glia. Further genetic manipulation studies are beginning to reveal how these mutations alter glial cell function and contribute to disease. Adding to the complexity in disease, glia can also be beneficial and promote regeneration and tissue repair by performing functions such as providing metabolic support, engulfing debris, and forming protective glial scars. This meeting will highlight the latest developments in glial cell biology obtained through studies of invertebrate and vertebrate model systems, as well as human tissue and cells, using the most up-to-date genetics, molecular biology, biochemistry, physiology, and imaging technologies. Using the goals and format of the eight prior extremely successful meetings as a guide, we plan to: 1) assemble an international meeting of scientists engaged in studies of glial biology and neuron-glia interactions; 2) discuss new and exciting developments in the field by selecting talks from openly submitted abstracts on the basis of scientific merit; 3) provide an opportunity for junior scientists of diverse backgrounds to present their data and engage in scientific discourse with more established investigators; and 4) promote collaborative interactions to accelerate the pace of discovery and identify novel approaches to better understand nervous system function and, ultimately, target glial cells to treat neurological diseases.

2022年冷泉港实验室会议胶质细胞在健康与疾病中的作用抽象的拟议的神经胶质细胞健康与疾病会议将在冷泉港举行实验室于 2022 年 7 月 21 日至 25 日举行。本次会议的目标是为交流快速发展的神经胶质生物学和神经元-神经胶质相互作用领域的成果。神经胶质细胞由一组不同的非神经元细胞组成，对神经系统至关重要这些细胞在发育、回路功能和神经疾病方面发挥着许多重要作用。角色，例如塑造发育中的电路，调节神经递质信号传导神经元，为神经元和其他神经胶质细胞提供代谢支持，支持快速和动作电位的有效传播，调节血管发育和血流，以及随着遗传工具的进步，调节疾病中的炎症级联反应。专门针对神经胶质细胞，我们现在对这些和机制有了更深入的了解神经胶质细胞在健康和疾病中的其他功能这包括神经胶质细胞活跃的新认识。在健康、稳态条件下调节神经回路功能、可塑性和行为。我们现在也了解这些功能在疾病中如何出错，从而导致回路功能障碍、慢性炎症以及神经元及其突触连接的破坏。还有明确的迹象表明，神经胶质细胞可能不仅对患病神经元做出反应以进行传播疾病，但它们是潜在病因的一部分，例如许多基因突变。与阿尔茨海默病和多发性硬化症（MS）等神经退行性疾病有关，进一步的基因操作研究开始揭示其中的机制。这些突变改变了神经胶质细胞的功能并导致疾病的复杂性。疾病，神经胶质细胞也可以是有益的，并通过执行来促进再生和组织修复功能，例如提供代谢支持、吞噬碎片和形成保护性胶质细胞本次会议将重点介绍通过神经胶质细胞生物学获得的最新进展。研究无脊椎动物和脊椎动物模型系统以及人体组织和细胞，使用最新的遗传学、分子生物学、生物化学、生理学和成像使用之前八次极其成功的会议的目标和形式作为基础。指南中，我们计划：1）召集从事神经胶质研究的科学家参加国际会议生物学和神经元-神经胶质细胞相互作用；2）讨论该领域新的和令人兴奋的发展根据科学价值从公开提交的摘要中选择演讲； 3) 提供不同背景的初级科学家有机会展示他们的数据并参与与更成熟的研究人员进行科学对话；4) 促进合作；互动以加快发现速度并确定新方法以更好地神经系统功能，并最终以神经胶质细胞为目标来了解神经系统疾病。