CSHL 2023 Brain Barriers Conference

CSHL 2023脑障碍会议

• 批准号: 10608583
• 负责人: DAVID J. STEWART
• 金额: $ 1.5万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-25 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10608583
• 关键词: 3-Dimensional; Academia; Aging; Antibodies; Autoimmune Diseases; Biology; Blood; Blood - brain barrier anatomy; Blood Vessels; Brain; COVID-19 pandemic; Cells; Central Nervous System; Central Nervous System Agents; Cerebrospinal Fluid; Collaborations; Communication; Communities; Data; Development; Disease; Drug Delivery Systems; Educational workshop; Ensure; Environment; Faculty; Female; Fostering; Future; Goals; Growth; Health; Human; Imaging technology; Immune; Impairment; Incentives; Industrialization; Industry; International; Knowledge; Laboratories; Life; Maintenance; Malignant Neoplasms; Meningeal lymphatic system; Mental disorders; Methods; Minority; Modeling; Modernization; Molecular; Nerve Degeneration; Neurodegenerative Disorders; Neurologic; Nonprofit Organizations; Nutrient; Oral; Organ; Organoids; Participant; Peer Review; Peripheral; Persons; Physiological; Postdoctoral Fellow; Prize; Proteomics; Publishing; Research; Research Institute; Research Personnel; STEM career; Schedule; Science; Scientific Advances and Accomplishments; Scientist; Series; Source; Stroke; Students; Techniques; Therapeutic; Toxin; Traumatic Brain Injury; Woman; Writing; blood cerebrospinal fluid barrier; career; genetic technology; graduate student; healing; imaging approach; innovation; interest; laboratory facility; lectures; meetings; nervous system disorder; neuropathology; novel strategies; pharmacologic; posters; recruit; senescence; success; symposium; transcriptomics; tumor; unpublished works; virtual

PROJECT SUMMARY Brain Barriers Cold Spring Harbor Laboratory March 28 - April 1, 2023 The proposed “Brain Barriers” meeting, to be held at the Cold Spring Harbor Laboratory (CSHL) from March 28- April 1, 2023, will assemble leaders in the fields of central nervous system (CNS) barriers, including the BBB and the blood-cerebrospinal fluid barrier, to present and discuss the latest scientific advances that will elucidate barrier function in health and disease. This application seeks support for the eighth meeting of a biennial series of CSHL meetings on this topic. Similar meetings in the field organized by other non-profit organizations have historically focused on more physiological or pharmacological aspects of the BBB. In contrast, this premiere scientific conference will emphasize modern, multi-tiered approaches spanning cellular, molecular, transcriptomic, proteomic, genetic, and imaging technologies to elucidate CNS barriers biology throughout life. CNS barrier topics to be discussed during the 2023 meeting include: (i) Emerging concepts and hot topics; (ii) Imaging approaches; (iii) Development, plasticity, and specialization; (iv) 3D and organoid CNS barrier models; (v) BBB-omics in health and disease; and (vi) Aging, senescence and neurodegeneration. Recent fundamental discoveries in CNS barriers including new knowledge regarding cell diversity and function in the human BBB, new advances in techniques to investigate barrier biology and the application of these new approaches to better understand BBB contribution to neurological diseases have set the stage for an unprecedented scientific discovery. As such, communication within the international research community is essential for fostering collaborations and fueling future advances in the field. Each session will be chaired by a pair of leading scientists at different career stages. Selected speakers will include 2-3 invited speakers as well as graduate students, postdoctoral fellows, and junior faculty selected from submitted abstracts. We have a strong emphasis on promoting junior investigators, including an entire session with platform presentations from selected young investigators and chaired by two junior faculty. One keynote lecture presented at the beginning of the meeting will provide an overview of the field and the critical background to stimulate discussion throughout the meeting. There will also be two poster sessions, one panel discussion on `Barriers to success for women and minorities in academia and industry: impact and solutions' followed by a workshop on “How to frame and write constructive and fair peer-review”. These sessions will provide support for the professional growth of all meeting attendees in particular women and minorities in STEM careers, and stimulate the scientific growth of all young scientists. Three poster prizes (1st, 2nd, and 3rd place) will be presented as late breaking short talks in the final session. The meeting has grown steadily since its inception in 2008 with a much higher virtual attendance during the COVID19 pandemic. We anticipate a meeting of moderate size (200-250 in-person participants and 150-250 virtual participants), including a high proportion of students and postdoctoral fellows.

项目摘要 脑屏障 冷泉港实验室 3月28日至2023年4月1日 拟议的“大脑障碍”会议将于3月28日在冷泉港实验室（CSHL）举行。 2023年4月1日，将在中枢神经系统（CNS）障碍领域组装领导者，包括BBB 以及脑脊液屏障，以介绍和讨论最新的科学进步，以阐明 健康和疾病的障碍功能。该申请寻求支持双年展系列的第八次会议 关于此主题的CSHL会议。其他非营利组织在该领域举行的类似会议也 从历史上看，BBB的更多物理或药物方面的重点是。相比之下，这个首映 科学会议将强调现代的多层方法，涵盖细胞，分子， 转录组，蛋白质组学，遗传和成像技术，以阐明CNS屏障一生的生物学。 在2023年会议期间将要讨论的中枢神经系统障碍主题包括：（i）新兴概念和热门话题； （ii） 成像方法； （iii）发展，可塑性和专业化； （iv）3D和Organoid CNS屏障模型； （v）健康与疾病中的BBB-omics； （vi）衰老，感应和神经退行性。最近的基本 中枢神经系统障碍中的发现，包括有关人类BBB中细胞多样性和功能的新知识， 研究障碍生物学的新技术和这些新方法的应用以更好 了解BBB对神经疾病的贡献为前所未有的科学奠定了基础 发现。因此，国际研究界内的沟通对于培养至关重要 合作和推动该领域的未来进步。每个会议将由一对主要科学家主持 在不同的职业阶段。选定的演讲者将包括2-3位受邀演讲者以及研究生 博士后研究员和初级教师从提交的摘要中选择。我们非常重视 促进初级调查人员，包括整个会议，并提供选定Young的平台演示 调查人员，由两个初级教师主持。会议开始时发表的一个主题演讲 将提供该领域和关键背景的概述，以激发整个会议期间的讨论。 还将举行两次海报会议，一个小组讨论`````'' 在学术界和工业中：影响力和解决方案，然后是关于“如何构图和撰写建设性的”研讨会 和公平的同行评审”。这些会议将为所有与会者的专业成长提供支持 特别是在STEM职业中的妇女和少数民族，并刺激所有年轻科学家的科学成长。 在最后会议中，将介绍三个海报隐私（第一，第二和第三名）作为晚期的短暂谈判。 自2008年成立以来，会议一直在悄悄地增长 大流行。我们预计会议中等的会议（200-250个面对面的参与者和150-250个虚拟 参与者），包括很大比例的学生和博士后研究员。