Inflammation, Microbiota and Cancer

炎症、微生物群和癌症

• 批准号: 9914619
• 负责人: Thale Cross Jarvis
• 金额: --
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9914619
• 关键词: Academic support; Adjuvant; Affect; Animals; Area; Asia; Basic Science; CAR T cell therapy; Cancer Biology; Cancer Patient; Cancer Vaccines; Cell Proliferation; Cells; Cellular Metabolic Process; Cessation of life; Chemotherapy and/or radiation; Clinical Investigator; Collaborations; Complex; Educational workshop; Environment; Epithelial; Epithelium; Ethnic Origin; Exposure to; Future; Generations; Goals; Government; High Prevalence; Immune; Immune response; Immunity; Immunology; Immunotherapy; Industrialization; Industry; Inflammation; Inflammatory; International; Knowledge; Learning; Link; Major Histocompatibility Complex; Malignant Neoplasms; Metabolic; Metabolic Pathway; Metabolism; Methodology; Mutagenesis; Natural Immunity; Oncology; Organ; Outcome; Participant; Play; Predisposition; Prevention strategy; Primary Neoplasm; Race; Radiation therapy; Research; Research Personnel; Role; Signal Transduction; Site; Surface; Taiwan; Therapeutic; Toxic effect; Training; Translational Research; Tumor Immunity; Tumor-infiltrating immune cells; Work; adaptive immunity; angiogenesis; cancer health disparity; cancer immunobiology; cancer prevention; cancer therapy; checkpoint inhibition; chemotherapy; clinical practice; clinical translation; combat; comorbidity; diet and cancer; disadvantaged population; ethnic difference; health difference; health disparity; immunoregulation; improved; interest; meetings; metabolic profile; metabolomics; microbiome; microbiota; neoplastic cell; novel; patient response; posters; prevent; programs; racial difference; receptor; response; side effect; symposium; treatment strategy; tumor; tumor metabolism; tumor microenvironment; tumor progression

ABSTRACT Support is requested for a Keystone Symposia conference entitled Inflammation, Microbiota and Cancer, organized by Drs. Giorgio Trinchieri, Jenny P.Y. Ting, Hsing-Jien Kung and Jennifer A. Wargo. The conference will be held in Taipei, Taiwan from May 17-21, 2020. The concept of inflammation being linked to tumor promoting and even initiating a tumor microenvironment has evolved to include a complex network of interactions: innate and acquired immune response to the tumor; metabolism in tumor and immune cells; local and systemic effects of the microbiota on tumor predisposition, promotion, response to chemotherapy, radiotherapy, and immune therapy; and finally cancer co-morbidities and therapeutic side effects. The metabolic tumor environment affects innate and immune cell metabolism and activity thus modulating tumor progression and the response to therapy, particularly immunotherapy, but also chemotherapy and radiotherapy. Innate signaling also affects the tumor microenvironment and a complex cross-talk involving innate receptors, trained immunity, and class I Major Histocompatibility Complex (MHC) regulates both inflammation and anti-tumor immunity. Also, rapid progress in experimental animals and more recently in cancer patients, is unraveling a complex interaction between the microbiota at epithelial surfaces and within the primary tumor and metastatic sites with response to therapy. This, in turn, is raising the hope to be able to predict patient response to different types of therapy and to target the microbiota for improving therapy response, decreasing toxicity and preventing co-morbidity. The new scientific areas that will be covered during this conference will bring together aspects of cancer biology and immunity that are often only discussed at separate specialized meetings. The presence of both basic and clinical investigators will expose the participants to these new concepts. This conference will also provide an opportunity to discuss and explore the clinical translation of this rapidly emerging new understanding of cancer immunobiology. Finally, as there is a growing interest regarding health differences that adversely affect ethnically distinct and/or disadvantaged populations, an afternoon workshop, entitled Effects of Race and Ethnicity on Microbiome: Impacts on Cancer Health Disparities will be incorporated into the conference program.

抽象的 请求支持Keystone研讨会会议，标题为炎症，微生物群和癌症， 由Drs组织。乔治·特林奇里（Giorgio Trinchieri） Ting，Hsing-Jien Kung和Jennifer A. Wargo。这 会议将于2020年5月17日至21日在台湾台北举行。 炎症与肿瘤促进甚至引发肿瘤微环境有关的概念已有 演变为包括复杂的相互作用网络：对肿瘤的先天和获得的免疫反应； 肿瘤和免疫细胞中的代谢；微生物群对肿瘤易感的局部和全身影响， 促进，对化疗，放疗和免疫治疗的反应；最后癌症合并症 和治疗性副作用。代谢肿瘤环境影响先天和免疫细胞代谢，以及 活性从而调节肿瘤进展和对治疗的反应，特别是免疫疗法，但也 化学疗法和放疗。先天信号传导还会影响肿瘤微环境和复合物 涉及先天受体，受过训练的免疫力和I类主要组织相容性复合物（MHC）的盘问 调节炎症和抗肿瘤免疫力。此外，实验动物的快速进步以及更多 最近，在癌症患者中，正在揭示上皮表面的微生物群之间的复杂相互作用 在原发性肿瘤和转移部位，并反应治疗。反过来，这引起了人们的希望 能够预测患者对不同类型疗法的反应，并靶向菌群以改善 治疗反应，降低毒性并预防合并症。新的科学领域 在本次会议期间涵盖的癌症生物学和免疫力的各个方面通常只是 在单独的专业会议上讨论。基本研究者和临床研究人员的存在将暴露 这些新概念的参与者。该会议还将提供讨论和 探索对癌症免疫生物学的新知识的临床翻译。最后， 由于对健康差异的兴趣越来越大，这些差异会对种族差异产生不利影响和/或 处境不利的人群，下午的研讨会，标题为“种族和种族对微生物组的影响：” 对癌症健康差异的影响将纳入会议计划。