MACS/WIHS Combined Cohort Study: Cook County Clinical Research Site (CC_CRS)

MACS/WIHS 联合队列研究：库克县临床研究中心 (CC_CRS)

• 批准号: 9903477
• 负责人: Mardge H Cohen
• 金额: $ 296.22万
• 依托单位: HEKTOEN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9903477
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Advisory Committees; Advocacy; Affect; Age; Aging; Applications Grants; Area; Award; Behavioral Sciences; Biological Testing; Cardiovascular Diseases; Cardiovascular system; Cessation of life; Chicago; Chronic Disease; Cities; Clinical; Clinical Data; Cohort Studies; Collaborations; Collection; Communities; Community Health; Complex; Consent; Consequences of HIV; Cost efficiency; County; Data; Data Analyses; Development; Distress; Enrollment; Epidemiology; Ethics; Fostering; Functional disorder; Funding; Future; Goals; Grant; HIV; HIV therapy; Health; Health Sciences; Intervention; Language; Lead; Leadership; Learning; Life; Liver diseases; Lung; Lung diseases; Malignant Neoplasms; Medical; Mental disorders; Mentorship; Metabolic; Morbidity - disease rate; Neurocognition; Neurocognitive; Oral health; Outcome; Participant; Pathogenesis; Persons; Positioning Attribute; Protocols documentation; Publications; Quality of life; Race; Recording of previous events; Research; Research Personnel; Resources; Risk; Sampling; Science; Scientist; Ships; Site; Sleep; Specimen; Structure; Substance abuse problem; Surveys; Time; Woman; Women’s Interagency HIV Study; adjudication; antiretroviral therapy; behavioral health; career; clinical research site; cohort; collaborative approach; comorbidity; cooking; disability; flexibility; improved; innovation; insight; men; microbiome; microbiome research; mortality; multidisciplinary; participant retention; pathogen; premature; prevent; recruit; social media; social stigma; socioeconomics; stressor; success; translational approach; urban poverty

Project Summary/Abstract Despite the availability of ever more potent antiretroviral therapy, the struggle to optimize the health of HIV- infected men and women continues, as they suffer and die from premature medical co-morbidities including cardiovascular, pulmonary disease, neurocognitive dysfunction and malignancies. The goal of the Chicago Cook County Clinical Research Site (CRS) of the MACS/WIHS Combined Cohort Study, formerly the Chicago Women's Interagency HIV Study, is to advance understanding of HIV-related co-morbidities and pathogenesis through scientific innovation and a translational approach involving investigators from basic, clinical, behavioral and community health sciences. In collaboration with the other national Clinical Research Sites and the Data Analysis and Coordinating Center, the site has developed a Unified Science Agenda that aims to holistically describe mechanisms underlying premature morbidity and mortality in HIV-infected persons. Cook County CRS investigators will lead or co-lead projects in Behavioral Science, Malignancy, Neurocognition, Sleep Science and Pathogenesis including initiatives related to Liver Disease, Oral Health, Microbiome Science and Outcome Adjudication. The Cook County CRS will contribute to HIV and multidisciplinary science by fostering collaboration through an open, inquisitive approach, sharing ideas and the rich data and specimen resources of the cohort with qualified experts who can further advance mechanistic understanding of HIV- associated co-morbidities. The Cook County CRS will also support promising and diverse early career investigators and those new to HIV research through pilot grants, intentional mentorship, and linkage to resources to support independent funding. Finally, through expansive engagement of cohort participants and community partners, the Cook County CRS will rapidly disseminate key study findings and obtain insight into the most pressing issues for Chicagoans affected by HIV to inform future scientific direction.

项目概要/摘要 尽管有更有效的抗逆转录病毒疗法可供使用，但优化艾滋病毒健康状况的斗争仍然存在 受感染的男性和女性仍在继续，因为他们因过早的合并症而遭受痛苦和死亡，包括 心血管、肺部疾病、神经认知功能障碍和恶性肿瘤。芝加哥厨师的目标 MACS/WIHS 联合队列研究的县临床研究中心 (CRS)，以前称为芝加哥 妇女机构间艾滋病毒研究旨在增进对艾滋病毒相关并发症和发病机制的了解 通过科学创新和转化方法，涉及基础、临床、 行为和社区健康科学。与其他国家临床研究中心合作 数据分析和协调中心，该网站制定了统一科学议程，旨在 全面描述艾滋病毒感染者过早发病和死亡的机制。厨师 县 CRS 调查员将领导或共同领导行为科学、恶性肿瘤、神经认知、 睡眠科学和发病机制，包括与肝病、口腔健康、微生物科学相关的举措 和结果裁决。库克县 CRS 将通过以下方式为艾滋病毒和多学科科学做出贡献： 通过开放、好奇的方式促进合作，分享想法以及丰富的数据和样本 拥有合格专家的队列资源，可以进一步推进对艾滋病毒机制的理解 相关的合并症。库克县 CRS 还将支持有前途且多样化的早期职业 通过试点资助、有意指导和与艾滋病毒研究的联系 支持独立资助的资源。最后，通过队列参与者的广泛参与和 库克县 CRS 将与社区合作伙伴迅速传播关键研究结果并深入了解 对于受艾滋病毒影响的芝加哥人来说，最紧迫的问题可以为未来的科学方向提供信息。