MACS/WIHS Combined Cohort Study: Cook County Clinical Research Site (CC_CRS)

MACS/WIHS 联合队列研究：库克县临床研究中心 (CC_CRS)

• 批准号: 10371199
• 负责人: Mardge H Cohen
• 金额: $ 299.01万
• 依托单位: HEKTOEN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10371199
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Advisory Committees; Advocacy; Affect; Age; Aging; Applications Grants; Area; Award; Behavioral Sciences; Biological Testing; Cardiovascular Diseases; Cardiovascular system; Cessation of life; Chicago; Chronic Disease; Cities; Clinical; Clinical Data; Cohort Studies; Collaborations; Collection; Communities; Community Health; Complex; Consent; Consequences of HIV; Cost efficiency; County; Data; Data Analyses; Development; Distress; Enrollment; Epidemiology; Ethics; Fostering; Functional disorder; Funding; Future; Goals; Grant; HIV; HIV therapy; Health; Health Sciences; Intervention; Language; Lead; Leadership; Learning; Life; Liver diseases; Lung; Lung diseases; Malignant Neoplasms; Medical; Mental disorders; Mentorship; Metabolic; Morbidity - disease rate; National Institute on Minority Health and Health Disparities; Neurocognition; Neurocognitive; Oral health; Outcome; Participant; Pathogenesis; Persons; Positioning Attribute; Protocols documentation; Publications; Quality of life; Race; Recording of previous events; Research; Research Personnel; Resources; Risk; Sampling; Science; Scientist; Ships; Site; Sleep; Specimen; Structure; Substance abuse problem; Surveys; Time; Woman; Women' s Interagency HIV Study; adjudication; antiretroviral therapy; behavioral health; career; clinical research site; cohort; collaborative approach; community engagement; comorbidity; cooking; disability; flexibility; improved; innovation; insight; men; microbiome; microbiome research; mortality; multidisciplinary; opportunistic pathogen; participant retention; premature; prevent; recruit; social media; social stigma; socioeconomics; stressor; success; translational approach; urban poverty

Project Summary/Abstract Despite the availability of ever more potent antiretroviral therapy, the struggle to optimize the health of HIV- infected men and women continues, as they suffer and die from premature medical co-morbidities including cardiovascular, pulmonary disease, neurocognitive dysfunction and malignancies. The goal of the Chicago Cook County Clinical Research Site (CRS) of the MACS/WIHS Combined Cohort Study, formerly the Chicago Women's Interagency HIV Study, is to advance understanding of HIV-related co-morbidities and pathogenesis through scientific innovation and a translational approach involving investigators from basic, clinical, behavioral and community health sciences. In collaboration with the other national Clinical Research Sites and the Data Analysis and Coordinating Center, the site has developed a Unified Science Agenda that aims to holistically describe mechanisms underlying premature morbidity and mortality in HIV-infected persons. Cook County CRS investigators will lead or co-lead projects in Behavioral Science, Malignancy, Neurocognition, Sleep Science and Pathogenesis including initiatives related to Liver Disease, Oral Health, Microbiome Science and Outcome Adjudication. The Cook County CRS will contribute to HIV and multidisciplinary science by fostering collaboration through an open, inquisitive approach, sharing ideas and the rich data and specimen resources of the cohort with qualified experts who can further advance mechanistic understanding of HIV- associated co-morbidities. The Cook County CRS will also support promising and diverse early career investigators and those new to HIV research through pilot grants, intentional mentorship, and linkage to resources to support independent funding. Finally, through expansive engagement of cohort participants and community partners, the Cook County CRS will rapidly disseminate key study findings and obtain insight into the most pressing issues for Chicagoans affected by HIV to inform future scientific direction.

项目摘要/摘要 尽管有更有效的抗逆转录病毒疗法的可用性，但为优化HIV的健康而进行了努力 受感染的男人和女人继续遭受痛苦和死亡，死于过早的医疗合并症 心血管，肺部疾病，神经认知功能障碍和恶性肿瘤。芝加哥厨师的目标 Mac/WIHS组合队列研究的县临床研究站点（CRS），以前是芝加哥 妇女的机构艾滋病毒研究是为了提高人们对HIV相关的合并症和发病机理的理解 通过科学创新和一种转化方法，涉及基本，临床， 行为和社区健康科学。与其他国家临床研究网站合作 该网站是数据分析和协调中心，开发了一个统一的科学议程，旨在 整体描述了艾滋病毒感染者的过早发病率和死亡率的基础机制。厨师 县CRS调查人员将领导或共同领导行为科学，恶性，神经认知的项目， 睡眠科学和发病机理，包括与肝病有关的举措，口腔健康，微生物学科学 和结果裁决。库克县CRS将为艾滋病毒和多学科科学做出贡献 通过开放，好奇的方法来促进协作，分享想法以及丰富的数据和标本 与合格专家的队列资源，他们可以进一步提高对HIV的机理理解 相关的合并症。库克县CRS还将支持有前途和多样化的早期职业 调查人员和艾滋病毒研究的新手通过飞行员赠款，有意的指导以及与 支持独立资金的资源。最后，通过共同参与者的广泛参与和 社区合作伙伴，库克县CRS将迅速传播关键的研究结果，并深入了解 受艾滋病毒影响的芝加哥人最紧迫的问题，以告知未来的科学方向。