MACS/WIHS Combined Cohort Study: Cook County Clinical Research Site (CC_CRS)

MACS/WIHS 联合队列研究：库克县临床研究中心 (CC_CRS)

• 批准号: 10223772
• 负责人: Mardge H Cohen
• 金额: $ 2.92万
• 依托单位: HEKTOEN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10223772
• 关键词: 2019-nCoV; Address; Adult; Age; Age-Years; Aging; Alcohol consumption; Alcohols; Baltimore; Behavioral; Cellular Phone; Cohort Studies; County; Data; Diabetes Mellitus; District of Columbia; Equilibrium; Estrogens; Evaluation; Functional disorder; Gender; HIV; HIV Infections; HIV Seronegativity; HIV Seropositivity; Health Personnel; Healthcare; Hearing; Hearing Aids; Hearing Tests; High-Frequency Hearing Loss; Hypertension; Immunologic Markers; Impaired cognition; Inflammation; Knowledge; Methods; National Health Interview Survey; National Health and Nutrition Examination Survey; Neurocognitive; Obesity; Overweight; Participant; Patient Self-Report; Persons; Phenotype; Physical activity; Pilot Projects; Prevalence; Publishing; Questionnaires; Race; Reporting; Research; Risk; Risk Factors; Severity of illness; Site; Smoking; Surveys; Symptoms; Testing; Vertigo; Woman; aged; antiretroviral therapy; clinical research site; co-infection; cognitive function; cohort; comorbidity; cooking; ethnic difference; follow-up; frailty; hearing impairment; immune activation; men; middle age; sociodemographics; symptom treatment; treatment comparison

Study of Hearing and Balance in Middle Aged and Aging Men and Women in the MACS- WIHS Combined Cohort Study Abstract According to the 2014 U.S. National Health Interview Survey, 5.5% of adults aged 18-39 years old self- reported trouble with hearing without a hearing aid. Among adults 40-69 years of age, the rate was 19% increasing to 43% among adults aged 70 and over with 63% reporting mild hearing loss. To date, there has been no published results from these survey data of people living with HIV (PLWH) due to lack of reported HIV status. In a pilot study of middle-aged and aging HIV positive and HIV seronegative men and women conducted in Washington DC and Baltimore, HIV infection was associated with low and high frequency hearing loss. But, more rigorous studies are needed, especially as more than half of PLWH in the U.S. are over the age of 50 years old. Besides age and race/ethnicity differences in hearing and balance, being overweight, increased alcohol consumption, smoking, less physical activity, the occurrence of hypertension and diabetes are common risk factors for hearing and balance problems. These risk factors may also be higher in PLWH and share a common hallmark of inflammation and immune activation. Furthermore, hearing and balance problems may contribute to neurocognitive and physical dysfunction, which are also of concern in aging PLWH. Finally, there is no research on the use of hearing testing applications in adults with HIV. Evaluation of the feasibility of using a hearing testing application and the accuracy of a smartphone hearing testing application in PLWH and their HIV seronegative counterparts are needed. We propose to address these gaps in knowledge by implementing cohort-wide administration of the NHANES hearing (and balance questionnaire) in the MACS-WIHS Combined Cohort Study (MWCCS) in approximately 4,100 active middle aged and aging men and women living with and without HIV. In a subset of participants from the Washington-DC and Baltimore sites with baseline hearing and balance data collected in 2009-2010 with follow-up testing in 2020-2021, we propose to investigate whether the trajectory of markers of immune activation and inflammation contribute to progression of hearing and balance issues, and whether a smartphone hearing test application may be a feasible method to capture hearing trouble in PLWH compared to HIV seronegative participants.

中老年男女听力与平衡能力的研究 在 MACS-WIHS 联合队列研究中 抽象的 根据 2014 年美国国家健康访谈调查，18-39 岁的成年人中有 5.5% 的人自我感觉良好。 报告在没有助听器的情况下出现听力问题。在40-69岁的成年人中，这一比例为19% 在 70 岁及以上的成年人中，这一比例上升至 43%，其中 63% 的人报告有轻度听力损失。迄今为止，已有 由于缺乏报告，这些艾滋病毒感染者（PLWH）的调查数据尚未公布。 艾滋病毒状况。在一项针对中老年艾滋病毒阳性和艾滋病毒血清阴性男性和女性的试点研究中 在华盛顿特区和巴尔的摩进行的研究表明，HIV 感染与低频率和高频率相关 听力损失。但是，还需要进行更严格的研究，特别是美国一半以上的感染者 50岁以上。除了听力和平衡方面的年龄和种族/民族差异外， 体重过重、饮酒增多、吸烟、体力活动减少、高血压的发生 糖尿病是听力和平衡问题的常见危险因素。这些风险因素也可能是 PLWH 中较高，并且具有炎症和免疫激活的共同特征。此外，听力 平衡问题可能会导致神经认知和身体功能障碍，这也是值得关注的 老年感染者。最后，还没有关于在成人艾滋病毒感染者中使用听力测试应用程序的研究。 评估使用听力测试应用程序的可行性和智能手机听力的准确性 需要对艾滋病病毒感染者及其艾滋病毒血清阴性者进行检测。我们建议解决 通过对 NHANES 听证会实施全队列管理（并平衡 MACS-WIHS 联合队列研究 (MWCCS) 中的问卷），涉及大约 4,100 名活跃的中产阶级 感染和未感染艾滋病毒的老年男女。在参与者的子集中 华盛顿特区和巴尔的摩站点，其中包含 2009-2010 年收集的基线听力和平衡数据 2020-2021年的后续测试，我们建议研究免疫标志物的轨迹是否 激活和炎症会导致听力和平衡问题的进展，以及是否 智能手机听力测试应用程序可能是发现感染者听力问题的可行方法 与艾滋病毒血清阴性参与者相比。