MACS/WIHS Combined Cohort Study: Cook County Clinical Research Site (CC_CRS)

MACS/WIHS 联合队列研究：库克县临床研究中心 (CC_CRS)

• 批准号: 10223772
• 负责人: Mardge H Cohen
• 金额: $ 2.92万
• 依托单位: HEKTOEN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10223772
• 关键词: 2019-nCoV; Address; Adult; Age; Age-Years; Aging; Alcohol consumption; Alcohols; Baltimore; Behavioral; Cellular Phone; Cohort Studies; County; Data; Diabetes Mellitus; District of Columbia; Equilibrium; Estrogens; Evaluation; Functional disorder; Gender; HIV; HIV Infections; HIV Seronegativity; HIV Seropositivity; Health Personnel; Healthcare; Hearing; Hearing Aids; Hearing Tests; High-Frequency Hearing Loss; Hypertension; Immunologic Markers; Impaired cognition; Inflammation; Knowledge; Methods; National Health Interview Survey; National Health and Nutrition Examination Survey; Neurocognitive; Obesity; Overweight; Participant; Patient Self-Report; Persons; Phenotype; Physical activity; Pilot Projects; Prevalence; Publishing; Questionnaires; Race; Reporting; Research; Risk; Risk Factors; Severity of illness; Site; Smoking; Surveys; Symptoms; Testing; Vertigo; Woman; aged; antiretroviral therapy; clinical research site; co-infection; cognitive function; cohort; comorbidity; cooking; ethnic difference; follow-up; frailty; hearing impairment; immune activation; men; middle age; sociodemographics; symptom treatment; treatment comparison

Study of Hearing and Balance in Middle Aged and Aging Men and Women in the MACS- WIHS Combined Cohort Study Abstract According to the 2014 U.S. National Health Interview Survey, 5.5% of adults aged 18-39 years old self- reported trouble with hearing without a hearing aid. Among adults 40-69 years of age, the rate was 19% increasing to 43% among adults aged 70 and over with 63% reporting mild hearing loss. To date, there has been no published results from these survey data of people living with HIV (PLWH) due to lack of reported HIV status. In a pilot study of middle-aged and aging HIV positive and HIV seronegative men and women conducted in Washington DC and Baltimore, HIV infection was associated with low and high frequency hearing loss. But, more rigorous studies are needed, especially as more than half of PLWH in the U.S. are over the age of 50 years old. Besides age and race/ethnicity differences in hearing and balance, being overweight, increased alcohol consumption, smoking, less physical activity, the occurrence of hypertension and diabetes are common risk factors for hearing and balance problems. These risk factors may also be higher in PLWH and share a common hallmark of inflammation and immune activation. Furthermore, hearing and balance problems may contribute to neurocognitive and physical dysfunction, which are also of concern in aging PLWH. Finally, there is no research on the use of hearing testing applications in adults with HIV. Evaluation of the feasibility of using a hearing testing application and the accuracy of a smartphone hearing testing application in PLWH and their HIV seronegative counterparts are needed. We propose to address these gaps in knowledge by implementing cohort-wide administration of the NHANES hearing (and balance questionnaire) in the MACS-WIHS Combined Cohort Study (MWCCS) in approximately 4,100 active middle aged and aging men and women living with and without HIV. In a subset of participants from the Washington-DC and Baltimore sites with baseline hearing and balance data collected in 2009-2010 with follow-up testing in 2020-2021, we propose to investigate whether the trajectory of markers of immune activation and inflammation contribute to progression of hearing and balance issues, and whether a smartphone hearing test application may be a feasible method to capture hearing trouble in PLWH compared to HIV seronegative participants.

中年和老年男性和女性的听力和平衡研究 在Macs- WIHS组合队列研究中 抽象的 根据2014年美国国家健康访谈调查，有5.5％的18-39岁的成年人自我 据报道，没有助听器的听力麻烦。在40-69岁的成年人中，率为19％ 在70岁及以上的成年人中增加到43％，报告了轻度听力损失。迄今为止，有 由于缺乏报道 艾滋病毒状况。在一项针对中年和衰老的艾滋病毒阳性和艾滋病毒血清症状的男性和女性的试点研究中 在华盛顿特区和巴尔的摩进行的HIV感染与低频和高频有关 听力损失。但是，需要更严格的研究，尤其是美国一半以上的PLWH是 超过50岁。除了年龄，种族/种族/种族差异外， 超重，饮酒量增加，吸烟，减少体育锻炼，高血压的发生 糖尿病是听力和平衡问题的常见风险因素。这些风险因素也可能是 PLWH的较高，并具有炎症和免疫激活的共同标志。此外，听到 平衡问题可能导致神经认知和身体功能障碍，这也令人关注 在老化的plwh中。最后，没有关于在艾滋病毒成年人中使用听力测试应用的研究。 评估使用听力测试应用程序的可行性和智能手机听证的准确性 需要在PLWH及其HIV血清负格的测试应用。我们建议解决 通过实施NHANES听证会范围内管理的知识差距（并平衡 问卷）在Macs-Wihs合并队列研究（MWCC）中，大约4,100个活动中间 与艾滋病毒无与伦比的老年男性和妇女。在一部分参与者中 华盛顿-DC和巴尔的摩站点，具有基线听力和平衡数据在2009 - 2010年收集的数据 2020 - 2021年的后续测试，我们建议研究免疫标记的轨迹 激活和炎症有助于听力和平衡问题的发展，以及是否有 智能手机听力测试申请可能是捕获PLWH中听力麻烦的可行方法 与艾滋病毒血清质参与者相比。