Central mechanisms of color vision

色觉的核心机制

基本信息

批准号：
9462123
负责人：
Gregory D Horwitz
金额：
$ 43.33万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-01-01 至 2021-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9462123
关键词：
Affect Appearance Awareness Behavior Behavioral Behavioral Paradigm Biological Models Categories Cells Color Color Perception Color Visions Color blindness Cone Contrast Sensitivity Detection Devices Disease Electrophysiology (science)Event Experimental Designs Frequencies Human Image Knowledge Light Longevity Macaca Measures Mediating Modeling Modernization Monkeys Neurons Noise Pathology Pattern Perception Peripheral Physiological Processes Process Recovery Research Retina Signal Transduction Standardization Stimulus Testing Time Time Perception Trauma Uncertainty V1 neuron Visible Radiation Vision Visual Visual system structure Work accurate diagnosis area V1 effective therapy experimental study information processing luminance nervous system disorder neuromechanism neuron component neurotransmission operation parvocellular phenomenological models public health relevance receptor relating to nervous system response temporal measurement

项目摘要

DESCRIPTION (provided by applicant): The visual system has emerged as a premier model for understanding information processing by neurons. Within vision, the submodality of color provides a particularly attractive experimental platform: we know a tremendous amount about the phenomenology of color perception and can explain some aspects of color perception, quantitatively and with high precision, by well- understood physiological processes. As a result of this progress, we can quickly and accurately diagnose many distinct forms of color blindness and can build devices that render colors accurately. On the other hand, surprising holes in our knowledge remain. The proposed research will fill this hole in our knowledge by determining where the temporal bottlenecks for detection and appearance reside. Three specific aims are planned: 1) Electrophysiological and modeling to determine where in the visual system luminance signaling is limited. 2) Electrophysiological and modeling to determine where in the visual system red- green chromatic signaling is limited. 3) Comparison of stimulus categories as classified by monkeys and by their component neurons to determine whether the dynamics of neuronal signals are responsible for changes in stimulus appearance as a function of temporal frequency. The proposed experiments will extend our knowledge toward an understanding of the principles that give rise to perception and its disorders. Such an understanding promises to provide the means to promote recovery of visual function following trauma or neurological disease.

描述（由申请人提供）：视觉系统已成为理解神经元信息处理的首要模型，在视觉中，颜色的子模态提供了一个特别有吸引力的实验平台：我们对颜色感知的现象学有大量了解，并且可以。通过充分理解的生理过程，以高精度解释颜色感知的某些方面。由于这一进展，我们可以快速准确地诊断许多不同形式的色盲，并可以构建准确渲染颜色的设备。另一方面，令人惊讶的漏洞拟议的研究将通过确定检测和外观的时间瓶颈所在来填补我们的知识空白：1）电生理学和建模以确定视觉系统中亮度信号的限制。 2) 电生理学和建模，以确定视觉系统中红绿色信号传导受到限制的位置。 3) 比较按猴子及其组成神经元分类的刺激类别，以确定神经信号的动态是否导致刺激外观的变化。作为所提出的实验将扩展我们对引起感知及其障碍的原理的认识，这种理解有望提供促进创伤或神经系统疾病后视觉功能恢复的方法。