System for documenting and tracking skin lesions

用于记录和跟踪皮肤病变的系统

• 批准号: 10484160
• 负责人: MEHRAN ARMAND
• 金额: $ 25.24万
• 依托单位: LUMO IMAGING LLC
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10484160
• 关键词: Address; Affect; Agreement; Algorithms; American; Appearance; Area; Atopic Dermatitis; Awareness; Basal Cell; Body Surface; Body Weight Changes; Cancerous; Caring; Cessation of life; Clinical; Clinical Research; Computer software; Consumption; Cutaneous; Data; Death Rate; Dermatologic; Dermatologist; Dermoscopy; Detection; Development; Devices; Diagnosis; Diagnostic; Disease; Documentation; Early Diagnosis; Eczema; Evolution; Future; Goals; Health Expenditures; Health Services Accessibility; Healthcare Systems; Image; Imaging Techniques; Incidence; Inflammatory; Institutional Review Boards; Lead; Lesion; Light; Literature; Location; Longitudinal Studies; Malignant Neoplasms; Manuals; Monitor; Morphology; Participant; Pathologist; Patient Monitoring; Patients; Persons; Phase; Photography; Pigments; Procedures; Prognosis; Psoriasis; Reading; Resolution; Scanning; Screening for Skin Cancer; Screening procedure; Sensitivity and Specificity; Skin; Skin Cancer; Small Business Technology Transfer Research; Software Tools; Squamous cell carcinoma; Standardization; System; Tablets; Techniques; Technology; Telephone; Testing; Time; Treatment Cost; Treatment Efficacy; United States; Visual; Visualization; Wait Time; Work; base; cancer diagnosis; cancer type; clinical imaging; cost; high risk; improved; interest; melanoma; mortality; new growth; novel; outpatient facility; patient prognosis; point of care; primary care setting; prototype; screening; screening program; skin lesion; standard of care; teledermatology; tool; underserved community; virtual; Address; Affect; Agreement; Algorithms; American; Appearance; Area; Atopic Dermatitis; Awareness; Basal Cell; Body Surface; Body Weight Changes; Cancerous; Caring; Cessation of life; Clinical; Clinical Research; Computer software; Consumption; Cutaneous; Data; Death Rate; Dermatologic; Dermatologist; Dermoscopy; Detection; Development; Devices; Diagnosis; Diagnostic; Disease; Documentation; Early Diagnosis; Eczema; Evolution; Future; Goals; Health Expenditures; Health Services Accessibility; Healthcare Systems; Image; Imaging Techniques; Incidence; Inflammatory; Institutional Review Boards; Lead; Lesion; Light; Literature; Location; Longitudinal Studies; Malignant Neoplasms; Manuals; Monitor; Morphology; Participant; Pathologist; Patient Monitoring; Patients; Persons; Phase; Photography; Pigments; Procedures; Prognosis; Psoriasis; Reading; Resolution; Scanning; Screening for Skin Cancer; Screening procedure; Sensitivity and Specificity; Skin; Skin Cancer; Small Business Technology Transfer Research; Software Tools; Squamous cell carcinoma; Standardization; System; Tablets; Techniques; Technology; Telephone; Testing; Time; Treatment Cost; Treatment Efficacy; United States; Visual; Visualization; Wait Time; Work; base; cancer diagnosis; cancer type; clinical imaging; cost; high risk; improved; interest; melanoma; mortality; new growth; novel; outpatient facility; patient prognosis; point of care; primary care setting; prototype; screening; screening program; skin lesion; standard of care; teledermatology; tool; underserved community; virtual

Project Summary The objective of this STTR proposal is to develop a system for longitudinally tracking the locations and morphologic changes to all Pigmented Skin Lesions on the patient’s body. The proposed software will build on a previously developed Total Body Photography (TBP) system, called Lumo Scanner, that can provide unprecedented resolution across the entire body surface. Skin cancers, including both melanoma and non- melanoma, are the most common type of cancer in the United States. Early-stage identification of suspicious pigmented lesions (SPLs) in primary care settings can lead to improved melanoma prognosis and a possible 20- fold reduction in treatment cost. The proposed device significantly reduces the clinicians’ time required for documenting lesions and for making diagnostic decisions, thereby allowing the healthcare system to better cope with the forecasted shortages of dermatologists. The proposed technology is novel in that it: 1) provides a standardized way of referring to lesions’ locations, 2) allows dermatologists to maintain a complete historical record of every lesion 3) detect significantly changed (evolved) lesions and 4) assists dermatologists in finding cancerous lesions at their very early stages to improve overall patient prognosis. The project team has already developed a Total Body Photography (TBP) system that is unlike the commercially available systems in that it obviates the need for using a dermatoscope and can produce images of sufficient resolution that can be used for early detection of skin cancers. This device has already received an IRB and has been installed at Johns Hopkins (JHU) Outpatient Center for its first clinical study. By your reading of this proposal is under review, JHU’s 100-patient study in which the efficacy of scan-based examinations will be compared with the efficacy of traditional clinical and dermatoscopic-based skin examinations, is well on its way. Within this proposal team intends to develop a temporal study tool that can follow all PSLs over time regardless of participants’ pose and weight changes between scanning sessions. Such a system will enable clinicians to accurately monitor patients’ PSLs over time, document any changes in previously identified lesions, and detect new lesions at the point of care. Within, the two phases of this project, the team will also focus on detecting evolved lesions and optimizing the scanning software to provide a better user interface for following and diagnosing pigmented skin lesions (PSL) while reducing the amount of time it takes for the dermatologist to fully document the patients lesions of interest. Though some literature suggests the epidemy in melanoma is the result of over-screening as evidenced by the number of deaths not increasing commensurately, others suggest that the low death-rate is the result of better screening. Regardless, there is unanimous agreement that too many lesions are studied by pathologists. Lumo Scanner when combined with the facilities developed in this project, will enable technicians perform highly accurate scans and thus allow the dermatologist to spend less documenting the high-risk patients. Also, this novel device will enable teledermatology in areas where there is a scarcity of dermatologists. Additionally, the proposed device can also be used for diagnosing and accurately monitoring the efficacy of therapies for psoriasis, atopic dermatitis, and other inflammatory skin conditions. Psoriasis and atopic dermatitis are also serious global problems. In the United States, psoriasis affects about 8 million people while about 31.6 million people in the United States have some form of eczema, including atopic dermatitis.

项目摘要 该STTR提案的目的是开发一个系统，用于纵向跟踪位置和 形态学改变了患者体内所有有色皮肤病变的变化。提出的软件将基于 先前开发的总体摄影（TBP）系统，称为Lumo Scanner，可以提供 整个身体表面的空前分辨率。皮肤癌，包括黑色素瘤和非 - 黑色素瘤是美国最常见的癌症类型。可疑的早期识别 初级保健环境中的小猪病变（SPL）可以改善黑色素瘤的预后，可能的20- 减少治疗成本。拟议的设备大大减少了临床医生的时间 记录病变和做出诊断决定，从而使医疗保健系统更好地应对 皮肤科医生的预测短缺。拟议的技术是新颖的：1）提供了 参考病变位置的标准化方式，2）允许皮肤科医生保持完整的历史 每个病变的记录3）检测到显着变化（进化）病变和4）协助皮肤科医生发现 癌变的早期阶段，以改善整体患者提示。 项目团队已经开发了全身摄影（TBP）系统，与商业上不同 可用的系统，因为它消除了使用皮肤镜的需求，并且可以产生足够的图像 可用于早期检测皮肤癌的分辨率。该设备已经收到IRB， 已安装在约翰·霍普金斯（JHU）门诊中心进行首次临床研究。通过您的阅读 提案正在审查，JHU的100名患者研究中，基于扫描的考试的效率将是 与传统的临床和基于皮肤镜检查的皮肤检查的效率相比，这是很好的。 在此提案团队中，打算开发一个临时学习工具，无论如何 参与者的姿势和体重变化之间的变化。这样的系统将使临床医生能够 准确监控患者的PSL，随着时间的流逝，记录先前鉴定的病变的任何变化，并检测 护理点的新病变。在该项目的两个阶段，团队还将专注于检测 进化的病变并优化扫描软件，以提供更好的用户界面，用于以下和 诊断皮肤病变（PSL），同时减少皮肤科医生完全的时间 记录感兴趣的患者病变。 尽管一些文献表明黑色素瘤中的发作是过度筛选的结果 死亡人数不相称，其他人则表明，低死亡率是更好的结果 筛选。无论如何，有一致的同意，病理学家太多的病变是研究的。 Lumo 扫描仪与该项目中开发的设施相结合时，将使技术人员能够发挥出色的作用 准确的扫描，从而使皮肤科医生能够减少记录高危患者的花费。另外，这个 新型设备将在皮肤科医生稀缺的地区实现远程表现。另外， 建议的设备也可以用于诊断，并准确监视疗法的效率 牛皮癣，特应性皮炎和其他炎症性皮肤状况。牛皮癣和特应性皮炎也是 严重的全球问题。在美国，牛皮癣会影响约800万人，而大约3160万 美国的人们有某种形式的湿疹，包括特应性皮炎。