Correlates of perceived size in V1 neurons

V1 神经元感知大小的相关性

• 批准号: 8209133
• 负责人: Gregory D Horwitz
• 金额: $ 22.25万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8209133
• 关键词: Accounting; Affect; Animal Model; Back; Behavioral; Brain; Brain Diseases; Brain Injuries; Complex; Cues; Data; Distant; Environment; Experimental Designs; Eye; Functional Magnetic Resonance Imaging; Future; Goals; Human; Illusions; Image; Individual; Investigation; Knowledge; Lead; Life; Light; Macaca; Measurement; Measures; Monkeys; Neurons; Perception; Positioning Attribute; Process; Property; Protocols documentation; Psychophysiology; Research Proposals; Retina; Retinal; Rewards; Role; Signal Transduction; Size Perception; Staging; Stimulus; Structure; Techniques; Testing; Tissues; V1 neuron; Vision; Visual; Visual Cortex; Visual Perception; Visual impairment; Visual system structure; area striata; base; experience; feeding; human subject; neurophysiology; receptive field; relating to nervous system; research study; response; retinotopic

The goal of this project is to use behavioral and single-unit recording techniques to understand the role of three-dimensional (3D) context in the neural processing of object size. Estimating the size of an object highlights a fundamental computational problem in vision: the inherent ambiguity in the retinal image. For any given retinal image there are an infinite number of combinations of object sizes and viewing distances that could give rise to that image. A fundamental challenge is to understand how distance information - which is not explicitly represented in the retinal image - is combined with retinal size information to achieve an accurate and stable representation of object size. The overarching framework of this proposal is that distance information is combined with retinal size information in early stages of the visual system. Convergent evidence from behavioral, fMRI, and ERP experiments in humans have shown that object size is represented in the primary visual cortex. These results are inconsistent with the primary visual cortex passively reflecting the stimulus on the retina, but rather suggest that high-level signals related to 3D scene interpretation may be fed back to primary visual cortex to adjust the amount of tissue allocated to represent visual objects. To extend these findings, our proposed experiments pursue these results in an animal model using psychophysical measurements and single-neuron electrophysiological recordings. Two specific aims are proposed: 1) single-unit recording to investigate the changes in receptive field structure of individual visual cortical neurons as a function of 3D context and 2) psychophysical measurements of size illusions in the same animal model used in specific aim 1. Together these specific aims will shed light on the processes that underlie size perception, which are critical for interacting with a 3D world, and will provide a bridge between vision studies in human and non-human subjects.

该项目的目标是使用行为和单个单元记录 理解三维 (3D) 上下文在神经网络中的作用的技术 物体尺寸的处理。估计物体的大小突出显示了 视觉中的基本计算问题：视网膜固有的模糊性 图像。对于任何给定的视网膜图像，都有无数种组合 可能产生该图像的物体尺寸和观看距离。一个 根本的挑战是理解距离信息——这不是 在视网膜图像中明确表示 - 与视网膜尺寸相结合 信息来实现物体尺寸的准确和稳定的表示。这 该提案的总体框架是结合距离信息 具有视觉系统早期阶段的视网膜尺寸信息。 来自行为、fMRI 和 ERP 实验的综合证据 人类已经证明，物体的大小是在初级视觉皮层中体现的。 这些结果与初级视觉皮层被动反射的结果不一致 视网膜上的刺激，而是表明与 3D 相关的高水平信号 场景解释可以反馈到初级视觉皮层来调整 分配代表视觉对象的组织量。为了扩展这些发现， 我们提出的实验使用动物模型来追求这些结果 心理物理测量和单神经元电生理学 录音。提出了两个具体目标：1）单单元记录 研究个体视觉皮层感受野结构的变化 神经元作为 3D 环境和 2) 大小的心理物理测量的函数 在特定目标中使用的同一动物模型中的错觉 1. 将这些 具体目标将揭示构成尺寸感知的过程， 对于与 3D 世界交互至关重要，并将在 人类和非人类受试者的视觉研究。