Central mechanisms of color vision

色觉的核心机制

• 批准号: 7781006
• 负责人: Gregory D Horwitz
• 金额: $ 43.75万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7781006
• 关键词: Accounting; Affect; Appearance; Behavioral; Biological Models; Categories; Cerebral cortex; Color; Color Perception; Color Visions; Color blindness; Data; Detection; Devices; Diagnosis; Discrimination; Disease; Educational process of instructing; Electrophysiology (science); Event; Face; Goals; Hand; Judgment; Knowledge; Light; Link; Maps; Measures; Mediating; Modeling; Monkeys; Motion; Neurons; Neurosciences; Noise; Output; Pathology; Perception; Peripheral; Physiological Processes; Population; Process; Property; Psychometrics; Psychophysics; Psychophysiology; Recovery; Reporting; Research; Retina; Retinal; Signal Transduction; Stimulus; System; Tactile; Testing; Trauma; V1 neuron; Vision; Visual system structure; area striata; behavior measurement; color detection; color processing; effective therapy; experience; information processing; meetings; nervous system disorder; neuromechanism; neurophysiology; novel; public health relevance; receptive field; receptor; relating to nervous system; research study; response; vibration; visual neuroscience; visual performance

DESCRIPTION (provided by applicant): The visual system has emerged as a premier model for understanding information processing by neurons. Within vision, the submodality of color provides a particularly attractive experimental platform: we know a tremendous amount about the phenomenology of color perception and can explain some aspects of color perception, quantitatively and with high precision, by well- understood physiological processes. As a result of this progress, we can quickly and accurately diagnose many distinct forms of color blindness and can build devices that render colors accurately. On the other hand, our understanding of the neurophysiology of color vision is largely restricted to the retina. The central mechanisms of color vision are largely unknown, and many aspects of color perception cannot be explained by retinal mechanisms. The proposed research is to measure the quality and behavioral relevance of the signals beyond the retina that mediate color vision. Two specific aims are planned: 1) Single neuron recording in the primary visual cortex to identify the neurons most likely to underlie color vision. 2) Single neuron recording in the primary visual cortex to study how manipulations that affect color appearance affect neuronal responses. The proposed experiments extend our knowledge of color vision toward an understanding of the principles of neuroscience that give rise to perception and its disorders. Such an understanding promises to provide the means to promote recovery of visual function following trauma or neurological disease. PUBLIC HEALTH RELEVANCE: Understanding how neurons mediate perception is an important step towards developing effective treatments for pathologies that disrupt perception. The proposed experiments exploit the model system of color vision, one of the most mature submodalities of vision, to reveal the neural events that relate activation of the peripheral receptors to perception.

描述（由申请人提供）：视觉系统已成为理解神经元信息处理的主要模型。在视觉中，颜色的表现提供了一个特别有吸引力的实验平台：我们知道颜色感知现象学的巨大数量，可以通过知名的生理过程来解释颜色感知的某些方面，并以定量和高精度来解释。由于这一进步，我们可以快速准确地诊断出许多不同形式的色盲形式，并可以构建可准确呈现颜色的设备。另一方面，我们对色觉神经生理学的理解在很大程度上仅限于视网膜。彩色视觉的中心机制在很大程度上是未知的，色彩感知的许多方面不能用视网膜机制来解释。拟议的研究是衡量介导色觉的视网膜以外信号的质量和行为相关性。计划了两个具体的目标：1）主要视觉皮层中的单个神经元记录，以识别最有可能构成色彩视觉的神经元。 2）主要视觉皮层中的单个神经元记录，以研究影响颜色外观的操纵如何影响神经元反应。提出的实验将我们对色觉的了解扩展到对神经科学原理的理解，这些神经科学原理引起了感知及其疾病。这种理解有望提供促进创伤或神经疾病后视觉功能恢复的手段。 公共卫生相关性：了解神经元如何介导感知是开发有效疗法的干扰感知的重要一步。提出的实验利用了彩色视觉模型系统，这是视力最成熟的表现，以揭示将周围受体激活与感知激活相关的神经事件。