Neural Environment in Disease: Glial Responses and Neuroinflammation

疾病中的神经环境：神经胶质反应和神经炎症

基本信息

批准号：
9763089
负责人：
Thale Cross Jarvis
金额：
$ 1.92万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-01 至 2020-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9763089
关键词：
Academia Adaptive Immune System Address Area Astrocytes Autoimmune Process Basic Science Behavior Blood - brain barrier anatomy Blood Vessels Cell physiology Cells Cellular biology Central Nervous System Diseases Cerebrovascular system Collaborations Colorado Complex Conflict (Psychology)Disease Disease Progression Educational workshop Effector Cell Environment Etiology Fostering Future Genetic Goals Health Human Image Immune Immune system Industrialization Industry Inflammatory Injury Invertebrates Knowledge Learning Lymphatic Mediating Mental disorders Methodology Microglia Modeling Nerve Degeneration Neuraxis Neurodegenerative Disorders Neuroglia Neurons Oligodendroglia Outcome Participant Pathogenesis Peripheral Physiological Processes Play Population Process Research Research Personnel Role Scientist Stimulus Stroke Techniques Technology Translational Research Traumatic injury Work adaptive immune response cell type clinical implementation clinical practice clinical translation glymphatic system induced pluripotent stem cell interest mouse model nervous system disorder neuroinflammation neuropsychiatric disorder neurovascular unit novel strategies novel therapeutics posters relating to nervous system repaired response response to injury symposium

项目摘要

ABSTRACT Support is requested for a Keystone Symposia conference entitled Neural Environment in Disease: Glial Responses and Neuroinflammation, organized by Drs. Richard Daneman, Dorothy Schafer, Michael V. Sofroniew and Vanda A. Lennon. The conference will be held in Keystone, Colorado from June 16-20, 2019. The response of the central nervous system to injury and disease is a complex physiological process that involves the coordinated actions of many different cell types. The interplay of neural cells and vascular cells along with the innate and adaptive immune systems determines the response to different injury and disease stimuli and whether the central nervous system will repair or degenerate. Understanding this complex cellular environment is essential to understanding disease pathogenesis, elucidating underlying disease etiology, and developing treatments for neurological and psychiatric diseases. The goal of this conference will be to bring together people who study different aspects of neurological diseases and facilitate the interchange of ideas necessary for identifying new mechanisms underlying complex intercellular interactions in the diseased nervous system. This will include people who study resident neural cells (neurons, astrocytes, oligodendrocytes), vascular cells (blood-brain barrier, lymphatics, glymphatics) and immune cells (microglia, innate peripheral immune cells, adaptive immune cells) in the context of a variety of neurodegenerative, neuroinflammatory, and neuropsychiatric diseases. Further, we will also attract people who implement different techniques including genetic mouse models, human iPSCs, invertebrate models, imaging, cell biology, and behavior in their research which will further facilitate exchange of ideas and foster collaboration. With the combined expertise at this conference, we will accelerate our ability to understand the complex neural response to injury and disease, which is a necessary step towards developing novel therapeutics for complex neurological diseases.

抽象的请求支持题为“疾病中的神经环境：神经胶质”的 Keystone 研讨会反应和神经炎症，由博士组织。理查德·丹曼、多萝西·谢弗、迈克尔·V. 索弗罗涅夫和万达·A·列侬。会议将于2019年6月16日至20日在科罗拉多州基斯通举行。中枢神经系统对损伤和疾病的反应是一个复杂的生理过程涉及许多不同细胞类型的协调行动。神经细胞和血管细胞的相互作用与先天性和适应性免疫系统一起决定对不同损伤和疾病的反应刺激以及中枢神经系统是否会修复或退化。了解这种复杂的细胞环境对于了解疾病发病机制、阐明潜在疾病病因以及开发神经和精神疾病的治疗方法。本次会议的目标将是带来聚集在一起研究神经系统疾病不同方面并促进思想交流的人们对于确定患病疾病中复杂的细胞间相互作用的新机制是必要的神经系统。这将包括研究常驻神经细胞（神经元、星形胶质细胞、少突胶质细胞）、血管细胞（血脑屏障、淋巴管、淋巴管）和免疫细胞（小胶质细胞、先天性外周免疫细胞、适应性免疫细胞）在各种神经退行性疾病的背景下，神经炎症和神经精神疾病。此外，我们还将吸引实施不同的人技术包括遗传小鼠模型、人类 iPSC、无脊椎动物模型、成像、细胞生物学和他们研究中的行为将进一步促进思想交流和促进合作。随着结合本次会议的专业知识，我们将加快理解复杂神经网络的能力对损伤和疾病的反应，这是开发复杂的新疗法的必要步骤神经系统疾病。