Immunometabolism, Metaflammation and Metabolic Disorders

免疫代谢、代谢炎症和代谢紊乱

• 批准号: 9762729
• 负责人: Thale Cross Jarvis
• 金额: $ 1.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-11 至 2020-02-10
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9762729
• 关键词: Animal Model; Area; Attention; Biology; British Columbia; Canada; Cells; Chronic; Clinical; Collaborations; Communities; Complex; Conflict (Psychology); Diabetes Mellitus; Discipline; Educational workshop; Event; Fostering; Future; Health; Health Promotion; Human; Immune; Immunity; Immunology; Knowledge; Lead; Learning; Metabolic; Metabolic Control; Metabolic Diseases; Metabolic Pathway; Metabolism; Methodology; Modeling; Molecular; Nutrient; Obesity; Outcome; Pathology; Physiological; Population; Research; Research Personnel; Scientist; Signal Transduction; Therapeutic; Tissues; Translating; Work; clinical practice; immune activation; improved; innovation; interest; posters; response; success; symposium

ABSTRACT Support is requested for a Keystone Symposia conference entitled Immunometabolism, Metaflammation and Metabolic Disorders, organized by Drs. Gökhan S. Hotamisligil, Ruslan M. Medzhitov and Karine Clément. The conference will be held in British Columbia, Canada from April 14-18, 2019. Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of these interactions underlie the emergence of many pathologies, particularly chronic non-communicable diseases such as obesity and diabetes. Understanding the complex immunometabolic signaling networks and the cellular and molecular events that occur in the setting of altered nutrient and energy exposures has the potential to lead to tangible therapeutic advancements to promote health. We have invited speakers working at the forefront of efforts to translate this biology into clinical approaches, to discuss the successes and limitations of this work thus far. This conference will cover the molecular mechanisms and physiological outcomes of immunometabolic interactions in the context of chronic metabolic diseases. Topics will range from the most evolutionarily conserved interactions studied in model organisms to human studies. There will be two sessions devoted to translational paths, covering both opportunities and challenges. This conference will be an opportunity for the scientific community to discuss and share their diverse perspectives on the integration of metabolism and immunity. We anticipate that this conference will bring together experts in the fields of immunology and metabolism to work together toward a common understanding of the intersection of these disciplines.

抽象的 请求支持Keystone研讨会会议，标题为“免疫代谢，元炎症”和 由Drs组织的代谢疾病。 GökhanS。Hotamisligil，Ruslan M. Medzhitov和KarineClément。 该会议将于2019年4月14日至18日在加拿大不列颠哥伦比亚省举行。 免疫和代谢反应之间的高度有序的相互作用在进化上是保守的，并且 组织和有机健康的最重要。这些互动的破坏是许多人的出现 病理，特别是慢性非通信疾病，例如肥胖和糖尿病。了解 复杂的免疫代谢信号网络以及在设置中发生的细胞和分子事件 营养和能量暴露的改变有可能导致切实的治疗进步 促进健康。我们邀请了在努力将这种生物学转化为临床的努力的最前沿的演讲者 方法，讨论迄今为止这项工作的成功和局限性。这次会议将涵盖 在慢性的背景下，免疫代谢相互作用的分子机制和物理结局 代谢疾病。主题的范围从模型中最进化配置的交互作用范围 人类研究的生物。将有两个专门用于翻译路径的会议，覆盖了这两个课程 机遇和挑战。这次会议将为科学界讨论和 分享他们对代谢和免疫力整合的看法。我们预料到了 会议将汇集免疫学和代谢领域的专家，以共同努力 对这些学科的交集的共同理解。