UNM Metal Exposure Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program

新墨西哥大学西南部部落土地金属暴露毒性评估 (METALS) 超级基金研究计划

• 批准号: 9544216
• 负责人: Johnnye L Lewis
• 金额: $ 128.77万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9544216
• 关键词: Address; Affect; Air; Back; Biological; Biological Testing; Biomedical Research; Cancer Center; Characteristics; Chronic Disease; Church; Collaborations; Communication; Communities; Complement; Country; DNA Damage; DNA Repair; Data; Decision Making; Disease; Environment; Environmental Health; Excision; Exposure to; Faculty; Financial compensation; Five-Year Plans; Foundations; Funding; Future; Generations; Goals; Hazardous Substances; Health; Home environment; Human; Immobilization; Immune; Indigenous; Individual; Intervention; Knowledge; Laboratory Study; Learning; Link; Metal exposure; Metals; Mining; Modeling; Monitor; Movement; Native Americans; Navajo; New Mexico; Outcome; Pathway interactions; Policies; Population; Positioning Attribute; Prevention; Property; Publications; Pueblo Race; Research; Research Personnel; Research Project Grants; Resources; Risk; Risk Reduction; Science; Scientist; Site; Superfund; System; Testing; Toxic effect; Toxicology; Training; Translating; Translational Research; Translations; Uncertainty; Universities; Uranium; Water; Work; base; cohort; community living; cost; cost effective; design; environmental toxicology; evidence base; graduate student; hazard; immune function; improved; indigenous community; literacy; member; metal poisoning; next generation; novel; physical property; programs; remediation; response; superfund site; synergism; therapy design; toxicant; tribal community; tribal lands; wasting

OVERALL – SUMMARY The UNM Metal Exposure and Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program (SRP) and Training Center will focus on risk reduction for Native Americans exposed to hazardous metals mixtures from abandoned uranium mine waste. This will be the ONLY SRP Center focused on risks to Native American communities. Specifically, UNM METALS will focus on site-specific physical/mineralogic/biogeochemical properties of the waste that alter immune function and DNA repair in tribal populations. The biomedical research proposed in UNM METALS focuses on major uncertainties in these exposure:outcome relationships, while environmental projects complement this research by exploiting characteristics that impact mobility and toxicity to develop and test novel cost-effective metals immobilization and removal strategies to reduce risks in ways compatible with tribal culture, and design risk avoidance/warning systems. Recognizing that complete remediation of these sites under CERCLA remains decades away, METALS will use multi-directional community engagement and research translation cores to develop and implement trans-generational approaches to risk communication and risk avoidance that integrate indigenous learning models (e.g. tribal ecological knowledge) and Western science. The METALS Center will integrate training of junior faculty and graduate students with multi-directional training of community members and research staff so that local knowledge of mining impacts and health problems inform air and water monitoring needs to support the environmental and biomedical research projects and build a foundation of transdisciplinary, partnered research for the next generation. METALS will utilize committed pilot funding from the UNM Cancer Center, the HSC Research Office, and our Environmental Health Signature Program to build transdisicplinary partnerships that expand our team to respond to additional health outcomes of community concern. The Center will expand ongoing, developed partnerships with three Native American communities living in close proximity to unique waste sites. The first is Laguna Pueblo living with the abandoned > 8000 acre openpit Jackpile Mine listed on the Superfund National Priorities List, and two Navajo communities living in proximity to two separate sites being addressed through CERCLA assessment as part of the USEPA Congressionally mandated Five-Year Plan to Address Uranium Contamination on the Navajo Nation: Red Water Pond Road adjacent to the North East Church Rock Mine; and Tachee-Blue Gap community living next to the Claim 28 waste site. In summary, we will work closely with communities, tribal and federal agencies to develop informed Superfund prioritization based on site-specific factors identified through our research, and develop solutions that build on site properties to immobilize and remove metals, reduce risk in ways that are holistic, predictable and sustainable, and test biological interventions to reduce toxicity.

总体 – 总结 新墨西哥州西南部落土地金属暴露和毒性评估 (METALS) 超级基金 研究计划 (SRP) 和培训中心将重点关注减少暴露于环境中的美洲原住民的风险 这将是 SRP 中心唯一关注的重点。 具体而言，新墨西哥州金属公司将重点关注特定地点的风险。 废物的物理/矿物学/生物地球化学特性改变部落的免疫功能和 DNA 修复 UNM METALS 提出的生物医学研究重点关注这些人群中的主要不确定性。 暴露：结果关系，而环境项目通过利用 影响迁移率和毒性的特性，以开发和测试新型经济高效的金属固定化 和清除策略，以与部落文化兼容的方式降低风险，并设计风险 认识到仍需根据 CERCLA 对这些地点进行彻底修复。 几十年后，METALS 将利用多方位的社区参与和研究翻译核心来 制定并实施跨代风险沟通和风险规避方法，将 本土学习模式（例如部落生态知识）和西方科学 METALS 中心将。 将初级教师和研究生的培训与社区成员的多方位培训结合起来 和研究人员，以便当地了解采矿影响和健康问题，了解空气和水 监测需要支持环境和生物医学研究项目并奠定基础 METALS 的下一代跨学科合作研究将利用来自承诺的试点资金。 UNM 癌症中心、HSC 研究办公室和我们的环境健康标志计划共同打造 跨学科合作伙伴关系扩大了我们的团队，以应对社区的额外健康成果 该中心将扩大与三个美洲原住民社区持续发展的伙伴关系。 第一个是 Laguna Pueblo，居住着超过 8000 名被遗弃的人。 英亩露天 Jackpile 矿被列入超级基金国家优先事项清单，两个纳瓦霍社区居住 靠近作为 USEPA 一部分通过 CERCLA 评估解决的两个独立地点 国会授权解决纳瓦霍族部落铀污染问题的五年计划：红色 Water Pond Road 毗邻 North East Church Rock Mine；紧邻 Tachee-Blue Gap 社区 到索赔 28 废物场总而言之，我们将与社区、部落和联邦机构密切合作， 根据我们研究确定的具体地点因素制定明智的超级基金优先顺序，以及 开发基于现场特性的解决方案来固定和去除金属，以以下方式降低风险 整体、可预测和可持续，并测试生物干预措施以减少毒性。