Understanding Risk Gradients from Environment on Native American Child Health Trajectories: Toxicants, Immunomodulation, Metabolic syndromes, & Metals Exposure

了解环境对美国原住民儿童健康轨迹的风险梯度：毒物、免疫调节、代谢综合征、

• 批准号: 10205869
• 负责人: Johnnye L Lewis
• 金额: $ 32.09万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10205869
• 关键词: Address; Affect; African American; Birth; COVID-19; COVID-19 pandemic; Caregiver Burden; Caregivers; Child; Child Health; Child Rearing; Cities; Cohort Studies; Collection; Communities; Consent; Data; Data Collection; Data Set; Development; Disasters; Discrimination; Ensure; Environment; Family; Frequencies; Future; Government; Home environment; Indigenous; Infrastructure; Internet; Intervention; Knowledge; Life; Measures; Metabolic syndrome; Metal exposure; Methods; Minority; Native Americans; Native-Born; Natural experiment; Navajo; Needs Assessment; Outcome; Participant; Population; Preparation; Prevalence; Protocols documentation; Reproducibility; Research; Risk; Schools; Services; Site; South Dakota; Stress; System; Testing; Time; Training; Trauma; Visit; Vulnerable Populations; cohort; coronavirus disease; data exchange; data portal; experience; immunoregulation; infection rate; insight; member; mortality; neurodevelopment; non-Native; pandemic disease; racism; response; screening; social exclusion; stressor; success; toxicant

Project Summary Available knowledge about how stress in the home environment influences child neurodevelopment points to the importance of capturing time-sensitive data on major stressors, such as the COVID-19 pandemic, across the many populations represented in ECHO. The collective ECHO data offers insight into an unfortunate natural experiment on how such a major stress affects ECHO children and families. Understanding this will allow for better preparation to meet the needs of affected children as they re-enter school and community life, while helping to mitigate the impacts of similar stressors in future disasters affecting children. Minority and marginalized populations are representative of US population prevalence in ECHO, but the total number of any group within the 55,000 ECHO children may still be relatively small. For example, most Native American ECHO participants are in 2 cohorts, and represent fewer than 1500 of the 55,000 children in ECHO. It is conceivable that time-sensitive measures such as responses to ECHO will be captured in very few, or none, of the ECHO participants within marginalized populations most affected. This ECHO NOSI application examines the relative pandemic-induced stress across multiple cohorts differing with respect to marginalization, COVID-19 population prevalence, and experience with historical trauma/systemic racism. At present, this comparison includes the Navajo Birth Cohort Study/ECHO (NBCS/ECHO) cohort, the PASS ECHO cohorts (Indigenous and non-Indigenous populations in South Dakota), and the Atlanta ECHO cohort of urban Black participants. We propose three aims to address our overall hypothesis that pandemic-induced stress will be greatest in populations experiencing the greatest rates of infection and mortality, but exacerbated by historical trauma in Indigenous and Black populations. Aim 1 will ensure availability of time-sensitive data to test this hypothesis in the future; Aim 2 will expand the opportunities for remote and lay staff collection of neurodevelopmental data to ensure availability for testing the hypothesis, and Aim 3 will test and develop a reliable system for transfer of NBCS data to the DAC NBCS portal at greater frequency than is currently possible with infrastructure limits. This is the first study exploring the impact of increased stress across communities already affected by historical trauma and facing a disaster like COVID-19 to address whether collective stress affects long-term child neurodevelopment through changes in parenting and the home environment, and will ensure minority cohorts are represented in the time-sensitive datasets in sufficient numbers to evaluate and compare impacts to develop mitigation interventions, rather than simply by population proportional representation.

项目概要 关于家庭环境中的压力如何影响儿童神经发育的现有知识表明 捕获有关主要压力源（例如 COVID-19 大流行）的时间敏感数据的重要性 ECHO 中代表的许多人群。集体 ECHO 数据提供了对不幸事件的洞察 关于如此大的压力如何影响 ECHO 儿童和家庭的自然实验。了解这一点将会 以便更好地做好准备，以满足受影响儿童重新进入学校和社区生活的需求， 同时帮助减轻未来影响儿童的灾难中类似压力源的影响。少数民族和 边缘化人群代表了 ECHO 中美国人群的患病率，但任何人群的总数 55,000 名 ECHO 儿童中的群体可能仍然相对较小。例如，大多数美洲原住民 ECHO 参与者分为 2 个组，代表 ECHO 55,000 名儿童中的不到 1500 名。这是可以想象的 对时间敏感的测量，例如对 ECHO 的响应，将在极少数或没有 ECHO 中捕获 边缘化人群中受影响最严重的参与者。 此 ECHO NOSI 应用程序检查了多个不同队列中流行病引起的相对压力 关于边缘化、COVID-19 人口流行率以及历史经验 创伤/系统性种族主义。目前，此比较包括纳瓦霍出生队列研究/ECHO (NBCS/ECHO) 队列、PASS ECHO 队列（南部土著和非土著人口） 达科他州），以及亚特兰大 ECHO 城市黑人参与者群体。我们提出三个目标来解决我们的问题 总体假设是，流行病引起的压力在经历最高比率的人群中将是最大的 感染和死亡率，但由于土著和黑人人口的历史创伤而加剧。目标1将 确保具有时间敏感数据的可用性，以在未来检验这一假设；目标 2 将扩大 远程和非专业工作人员有机会收集神经发育数据，以确保测试的可用性 假设，目标 3 将测试和开发一个可靠的系统，用于将 NBCS 数据传输到 DAC NBCS 门户网站的频率比目前基础设施限制下可能的频率更高。 这是第一项探讨压力增加对已经受历史影响的社区的影响的研究 创伤和面对像 COVID-19 这样的灾难，以解决集体压力是否会影响长期儿童 通过改变养育方式和家庭环境来神经发育，并将确保少数群体 在时间敏感的数据集中有足够的数量来评估和比较影响 制定缓解干预措施，而不是简单地通过人口比例代表制。