Early Life Determinants of Child Health: A New Denver-Based Cohort

儿童健康的早期决定因素：丹佛的一个新队列

• 批准号: 10745631
• 负责人: Dana Dabelea
• 金额: $ 256.11万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745631
• 关键词: 3-Dimensional; Address; Adverse effects; Affect; Air Pollution; Biogenesis; Biological; Birth; Cannabinoids; Chemical Exposure; Chemicals; Child; Child Health; Child Welfare; Childhood; Colorado; Conceptions; Data; Data Collection; Data Element; Development; Diet; Disease; Endocrine Disruptors; Enrollment; Ensure; Environment; Environmental Exposure; Epigenetic Process; Ethnic Origin; Exclusive Breastfeeding; Exposure to; Family; Federally Qualified Health Center; Goals; Green space; Growth; Health; Hospitals; Human Milk; Individual; Infant; International; Intervention; Joints; Lactation; Lead; Life; Life Style; Link; Measures; Mediating; Obesity; Outcome; Parents; Participant; Pathway interactions; Patient Care; Pattern; Persons; Pilot Projects; Policies; Policy Maker; Population; Population Heterogeneity; Positioning Attribute; Predisposition; Pregnancy; Prenatal Nutrition; Prenatal care; Prevention; Probability; Procedures; Protocols documentation; Race; Research; Research Personnel; Resources; Risk; Sample Size; Science; Site; System; Toddler; Urban Hospitals; cardiometabolism; cohort; data resource; design; early life exposure; environmental chemical; environmental chemical exposure; environmental tobacco smoke exposure; epigenetic marker; experience; improved; lifestyle factors; marijuana use; molecular marker; neurodevelopment; novel; obesity in children; obesity risk; offspring; postnatal; postnatal period; pregnant; prenatal; prenatal exposure; prevent; programs; protective factors; recruit; response; retention rate; risk minimization; social health determinants; socioeconomics; sperm cell

PROJECT SUMMARY Our overarching goal is to recruit and follow a new cohort of pregnant people and their partners, to implement longitudinal data collection using the ECHO Cohort Protocol, and to lead ECHO-wide analyses that advance understanding of when and how exposures during preconception, prenatal, and postnatal/lactational periods influence a broad range of child health outcomes. We will lead solution-oriented science to target adverse environmental exposures that may be prevented through policy, programs, and practices, and to identify positive influences in the preconception, prenatal, and postnatal periods that may be promoted to mitigate health risks associated with adverse early-life exposures. We will leverage our local investigator and staff expertise to enroll pregnant people, their conceiving partners, and their offspring from a large network of Federally Qualified Health Centers serving a racially, ethnically, and socioeconomically diverse population in Denver, Colorado. In Aim 1, we propose to utilize the breadth of Core data elements in the ECHO Cohort Protocol to answer solution-oriented research questions regarding the link between early-life exposures and childhood health outcomes, and to identify modifiable prenatal and postnatal factors that may minimize risk. In Aim 2, we propose to implement novel and scalable Specialized measures to determine biological pathways linking parent and family lifestyle factors and the physical/chemical environment of early life with child obesity and neurodevelopment, and to identify susceptible periods for these exposures in early life. In Aim 3, we describe our plans to recruit and follow a diverse cohort of over 800 pregnant people with their conceiving partner and offspring, and to additionally enroll over 300 participants with a high probability of subsequent pregnancy into a preconception study. In Aim 4, we propose research questions that utilize data elements collected during the preconception period, to identify parental preconception exposures that adversely affect child health outcomes, and to describe molecular markers that may mediate these effects. Our team of expert investigators is well-positioned to contribute to the development of the ECHO specialized exposure and outcome protocols, and to the design and implementation the preconception pilot study. Our experienced staff and MPI team will ensure successful recruitment and implementation of the ECHO Cohort Protocol to provide a robust sample size and high-quality data. We will lead ECHO-wide analyses to address pressing questions in the early-life origins of child health and disease, and to identify potential targets for prevention of adverse environmental exposures and for promotion of protective factors in early life.

项目摘要 我们的总体目标是招募和关注新的孕妇及其伴侣，以实施 使用回声队列协议的纵向数据收集，并领导Echo范围的分析 理解何时以及如何在出生，产前和产后/泌乳期间的暴露时间 影响着广泛的儿童健康成果。我们将领导面向解决方案的科学以靶向不利 通过政策，计划和实践可以预防的环境暴露，并确定 可能促进以减轻的观念，产前和产后时期的积极影响 与不良早期暴露有关的健康风险。我们将利用当地的调查员和员工 招募孕妇，构思的伴侣以及他们的后代的专业知识 联邦资格的卫生中心在种族，种族和社会经济上为多样化的人口提供服务 科罗拉多州丹佛。在AIM 1中，我们建议在Echo队列中利用核心数据元素的广度 回答有关早期暴露与早期暴露与联系的方案研究问题的协议 儿童健康结果，并确定可改变的产前和产后因素，这些因素可能最小化风险。在 AIM 2，我们建议实施新颖和可扩展的专业措施以确定生物学途径 将父母和家庭生活方式因素以及早期生活的物理/化学环境联系起来与儿童肥胖 和神经发育，并确定早期生活中这些暴露的敏感时期。在AIM 3中，我们 描述我们的计划，招募和关注800多名孕妇的各种各样的人群 合作伙伴和后代，并为300多名参与者注册，随后的可能性很高 怀孕进入先男性的研究。在AIM 4中，我们提出了利用数据元素的研究问题 在预想时期收集，以确定父母的先男接触暴露对不利影响 儿童健康结果，并描述可能介导这些作用的分子标记。我们的专家团队 调查人员有充分的位置，可以为回声专业曝光的发展做出贡献 结果方案，以及设计和实施先入后的试点研究。我们经验丰富的员工 MPI团队将确保成功招募和实施回声队列协议以提供 强大的样本量和高质量数据。我们将进行回声范围的分析，以解决 儿童健康和疾病的早期生命起源，并确定预防不良的潜在目标 环境暴露和促进早期保护因素。