UNM Metals Exposure and Toxicity Assessment on tribal Lands in the Southwest (METALS) Superfund Research Program

新墨西哥大学西南部部落土地的金属暴露和毒性评估 (METALS) 超级基金研究计划

• 批准号: 10353201
• 负责人: Johnnye L Lewis
• 金额: $ 183.9万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10353201
• 关键词: Address; Age; Agriculture; Arsenic; Arts; Autoantibodies; Belief; Biological; Biological Availability; Biological Monitoring; Bioreactors; Bioremediations; Cells; Chronic; Chronic Disease; Clinical; Clinical Trials; Collaborations; Communities; Congresses; DNA Repair; Data; Development; Dose; Economics; Ensure; Environment; Equilibrium; Exposure to; Family; Funding; Health; Home; Hypertension; Immune; Immune System Diseases; Immunity; Indigenous; Inflammation; Inflammatory; Ingestion; Inhalation; Intervention; Language; Lead; Left; Link; Lung; Metabolic Biotransformation; Metal exposure; Metals; Mining; Modeling; Movement; Native-Born; Navajo; New Mexico; Nuclear Weapon; Oral; Oxidative Stress; Particulate; Pathway interactions; Phase; Plants; Policies; Policy Maker; Population; Prevalence; Process; Production; Property; Pueblo Race; Reference Values; Research; Research Personnel; Resources; Rest; Risk; Risk Reduction; Role; Route; Safety; Science; Signal Recognition Particle; Site; Superfund; Symbiosis; Testing; Thinking; Time; Tissues; Toxic effect; Translations; Transmission Electron Microscopy; Universities; Uranium; Vanadium; War; Weather; Work; Zinc; base; community partnership; cost effective; cytokine; design; disorder risk; exposure route; federal policy; geochemistry; immune function; improved; metal complex; metal poisoning; multidisciplinary; multimodality; nanoparticle; novel; novel strategies; particle; physical property; plant fungi; programs; remediation; response; sound; therapy design; toxic metal; translational approach; tribal lands; uptake; vulnerable community; wasting; weapons

OVERALL Summary METALS The UNM Metal Exposure and Toxicity Assessment on tribal Lands of the Southwest SRP Center (METALS) focuses on >500 abandoned uranium mines (AUMs) on Navajo Nation, and the Jackpile Mine on Laguna Pueblo, a legacy of the Cold War now being assessed under CERCLA. They represent >4500 AUMs in the 15 Western US that are home to >1/2 of our Indigenous population. During the inaugural phase of METALS, our team worked in close partnership with our Indigenous partners to determine that since mining began in the 1940s, weathering of metal mixtures in the millions of tons of waste has produced nanoparticles of varying mineralogy. While these nanoparticles have implications for both mobility and toxicity of the waste, they are not considered in prioritization or clean-up due to significant data gaps. Our health studies have shown that exposures to these metal mixtures increase the prevalence of hypertension, multiple chronic diseases, and immune dysfunction, and autoantibody production. While ~25% of the population shows no evidence of exposures, biomonitoring confirms an equivalent %age show exposure to clusters of up to 12 metals at significantly higher concentrations than the rest of the US population. Our community-partnered approach and strong team integration inclusive of community partners has allowed our design of clinical interventions that are scientifically sound and respectful of culture, in which we have high rates of participation and compliance. Phase 2 of METALS will build on our strong community partnerships to drive our research by their needs, and use single atom, state of the science, transmission electron microscopy to both answer community questions on agricultural safety as impacted by particulate redistribution, and understand the processes of resuspension, environmental mobility, and plant uptake at a mechanistic scale to inform risk reduction. Our confirmation of multiple routes of exposures, and evidence of metals-induced inflammation and oxidative stress lead us to examine contributions of ingestion and inhalation within community exposures. These studies will explore the potential for high-dose exposures to immune regulatory cells in lung and gut to alter systemic immune function, informing design of more targeted intervention. Our recognition of the role of plant/fungi symbiosis in transformation of environmental metal mixtures has led to our collaboration with the national Sevilleta Long Term Ecological Research program in New Mexico in development and testing of fungal bioreactors based in the balance of native fungal communities and their interactions with geochemical variables as a remediation strategy. These remediation approaches provide a novel strategy to overcome the ineffectiveness of bacterial bioreactors in our oxic environment and produce sustainable, cost-effective solutions to protect key resources of cultural importance. Our team will build on our strong partnerships to build common dialogue with communities, researchers, clinicians, tribal and federal policy makers, informed by our solution-oriented team science to inform risk reduction at community, clinical and policy levels.

金属总体总结 UNM 对西南 SRP 中心部落土地的金属暴露和毒性评估 (METALS) 重点关注纳瓦霍族保留地超过 500 个废弃铀矿 (AUM)，以及 拉古纳普韦布洛 (Laguna Pueblo) 是冷战遗产，目前正在根据 CERCLA 进行评估。他们代表超过 4500 个 AUM 美国西部 15 个地区居住着超过 1/2 的原住民人口。在启动阶段 METALS，我们的团队与我们的本土合作伙伴密切合作，确定自采矿以来 从 20 世纪 40 年代开始，数百万吨废物中的金属混合物风化产生了纳米颗粒 不同的矿物学。虽然这些纳米粒子对废物的流动性和毒性都有影响， 由于显着的数据差距，它们在优先级排序或清理中不被考虑。我们的健康研究有 研究表明，接触这些金属混合物会增加高血压、多种慢性病的患病率 疾病、免疫功能障碍和自身抗体的产生。虽然约 25% 的人没有表现出 暴露证据，生物监测证实了暴露于多达 12 个簇的等效百分比年龄 金属的浓度明显高于美国其他人口。我们的社区合作伙伴 方法和包括社区合作伙伴在内的强大团队整合使我们能够设计临床 科学合理且尊重文化的干预措施，我们的参与率很高 和合规性。 METALS 的第二阶段将建立在我们强大的社区合作伙伴关系的基础上，通过以下方式推动我们的研究： 他们的需求，并使用单原子、科学现状、透射电子显微镜来回答这两个问题 社区对颗粒物重新分布影响的农业安全问题，并了解 机械规模的再悬浮、环境流动和植物吸收过程以告知风险 减少。我们对多种暴露途径的确认以及金属引起的炎症和 氧化应激促使我们研究摄入和吸入对社区暴露的影响。 这些研究将探索高剂量暴露于肺和肠道免疫调节细胞的潜力 改变全身免疫功能，为更有针对性的干预设计提供信息。我们对角色的认可 植物/真菌在环境金属混合物转化中的共生促使我们与 新墨西哥州塞维利亚国家长期生态研究计划，开发和测试 基于本地真菌群落平衡及其与地球化学相互作用的真菌生物反应器 变量作为补救策略。这些补救方法提供了一种新的策略来克服 细菌生物反应器在我们的含氧环境中无效并产生可持续的、具有成本效益的 保护重要文化资源的解决方案。我们的团队将建立在我们强大的合作伙伴关系的基础上 与社区、研究人员、临床医生、部落和联邦政策制定者建立共同对话， 我们以解决方案为导向的团队科学为社区、临床和政策层面的风险降低提供信息。