Prenatal exposure to phthalates and neurodevelopment in children

产前接触邻苯二甲酸盐与儿童神经发育

• 批准号: 9336909
• 负责人: SHARON K. SAGIV
• 金额: $ 7.85万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9336909
• 关键词: 7 year old; Adolescence; Age; Animals; Anxiety; Attention; Behavior; Behavioral; Biological; Birth; Brain; Breathing; Chemicals; Child; Childhood; Chronic; Cognition; Cognitive; Comprehension; Consumer Product Safety; Cosmetics; Data; Data Quality; Dermal; Development; Diet; Endocrine Disruptors; Environment; Exposure to; Fetus; Food Packaging; Health; Homeostasis; Hour; Human; Hyperactive behavior; Literature; Longitudinal cohort; Measures; Mediating; Medical Device; Memory impairment; Methods; Mothers; Nature; Nervous system structure; Neuropsychology; Neurosecretory Systems; Neurotoxins; Outcome; Parents; Pathway interactions; Performance; Placenta; Plasticizers; Plastics; Population; Pregnancy; Public Health; Recruitment Activity; Reporting; Research; Rodent; Salinas Valley; Sample Size; Sampling; Short-Term Memory; Statistical Models; Testing; Thyroid Hormones; Time; Toxic effect; Toy; Urine; Work; absorption; age group; androgenic; base; building materials; chemical group; cognitive development; cohort; design; early adolescence; early life exposure; epidemiology study; executive function; exposed human population; externalizing behavior; flexibility; hazard; neurodevelopment; offspring; personal care products; phthalates; policy implication; prenatal; prenatal exposure; processing speed; resilience; social cognition; teacher; urinary

ABSTRACT Phthalates are synthetic chemicals used in personal care products and in flexible plastic products. Along with their metabolites, phthalates are rapidly excreted in humans with half-lives of 5-24 hours. Exposure to phthalates is ubiquitous because of their widespread use and their ability to leach easily into the environment. Phthalates are endocrine-disrupting chemicals that may interfere with neuroendocrine pathways involved in neurodevelopment, including anti-androgenic activity and thyroid hormone homeostasis. The prenatal period is a particularly sensitive target for phthalate exposure due to rapid brain development. Previous studies of phthalates and neurodevelopment are limited by small sample size, cross-sectional design, and limited data on neurodevelopment. The primary objective of the proposed research is to investigate the association of prenatal exposure to phthalates with cognitive and behavioral development in childhood and adolescence. We will examine these relationships in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS), a large, well-characterized longitudinal pre-birth cohort of mothers recruited 1999-2000 during pregnancy and their offspring. We will analyze existing data on maternal phthalate levels, measured twice during pregnancy (~13 and 26 weeks), in relation to the cohort's extensive data on neurodevelopment measured from age 7 years until adolescence for 336 children with exposure and outcome data. We will examine associations with the following outcomes: (1) general cognition, (2) executive function, (3) attention problems, externalizing behaviors and internalizing behaviors, and (4) social cognition. This study will take advantage of the CHAMACOS cohort's longitudinal data collected on teacher- and parent-rated scales as well as objective, performance-based tests. Additionally, this will be the first study to examine associations of phthalates with neurodevelopmental measures in adolescence, a critical time for manifestations of early life exposure effects. Results of this study, which will further our understanding of the long-term impact of early-life exposure to phthalates on neurodevelopment, have important policy implications given that widespread exposure to these chemicals in personal care products is modifiable and alternatives may be available during sensitive time windows, such as pregnancy.

抽象的 邻苯二甲酸盐是用于个人护理产品和柔性塑料产品的合成化学品。连同 其代谢物邻苯二甲酸盐在人体中迅速排泄，半衰期为 5-24 小时。接触 邻苯二甲酸盐因其广泛使用且易于渗入环境中而无处不在。 邻苯二甲酸盐是内分泌干扰化学物质，可能会干扰神经内分泌途径 神经发育，包括抗雄激素活性和甲状腺激素稳态。产前期是 由于大脑快速发育，邻苯二甲酸盐暴露是特别敏感的目标。以前的研究 邻苯二甲酸盐和神经发育受到样本量小、横截面设计和有限数据的限制 神经发育。拟议研究的主要目的是调查产前 接触邻苯二甲酸盐对儿童和青少年认知和行为发展的影响。我们将 在萨利纳斯母亲和儿童健康评估中心检查这些关系 （CHAMACOS），是 1999 年至 2000 年期间招募的一个大型、特征明确的纵向产前母亲队列。 怀孕及其后代。我们将分析两次测量的母体邻苯二甲酸盐水平的现有数据 怀孕期间（约 13 周和 26 周），与该队列有关神经发育的广泛数据相关 对 336 名儿童从 7 岁到青春期的暴露情况和结果数据进行了测量。我们将 检查与以下结果的关联：(1) 一般认知，(2) 执行功能，(3) 注意力 问题、外化行为和内化行为，以及（4）社会认知。这项研究将采取 还利用了 CHAMACOS 队列在教师和家长评分量表上收集的纵向数据 作为客观的、基于绩效的测试。此外，这将是第一项检查关联性的研究 邻苯二甲酸盐对青春期神经发育的影响，这是早期生命表现的关键时期 曝光效果。这项研究的结果将进一步加深我们对早期生活的长期影响的理解 鉴于广泛存在的邻苯二甲酸盐对神经发育的影响，具有重要的政策影响 在个人护理产品中接触这些化学物质是可以改变的，并且在期间可能有替代品 敏感的时间窗口，例如怀孕。