Prenatal exposure to polyfluoroalkyl chemicals (PFCs) and child growth and develo

产前接触多氟烷基化学品 (PFC) 与儿童生长发育

• 批准号: 8397157
• 负责人: SHARON K. SAGIV
• 金额: $ 64.24万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-23 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8397157
• 关键词: 3 year old; 7 year old; Accounting; Acids; Address; Adverse effects; Affect; Age; Alkanesulfonates; Animals; Antibodies; Archives; Attention deficit hyperactivity disorder; Behavior; Behavioral; Birth; Blood Pressure; Blood specimen; Carpet; Chemical Exposure; Chemicals; Child; Child Development; Childhood; Cholesterol; Cognition; Data; Development; Dose; Enhancing Antibodies; Environment; Epidemiologic Studies; Exposure to; Fetus; First Pregnancy Trimester; Food Packaging; Furniture; Growth; Growth and Development function; Head circumference; Health; Height; High Density Lipoprotein Cholesterol; Human; Hypertension; Industrial Product; Infant; Insulin; Insulin Resistance; Intelligence; Investigation; Iodide Peroxidase; LDL Cholesterol Lipoproteins; Language; Lipids; Literature; Maternal Physiology; Measurement; Measures; Mediating; Metabolic; Modeling; Modification; Mothers; Neonatal; Newborn Infant; Obesity; Outcome; Pathway interactions; Placenta; Plasma; Population; Pregnancy; Public Health; Recruitment Activity; Research; Research Project Grants; Resistance; Risk Factors; Role; Sampling; Serum; Skinfold Thickness; Staining method; Stains; Surface; Textiles; Thyroid Function Tests; Thyroid Hormones; Thyrotropin; Thyroxine; Weight; Whole Blood; Work; adiponectin; chemical property; cohort; consumer product; cost effective; early childhood; executive function; fasting glucose; fetal; hazard; human data; human tissue; indexing; infancy; interest; neurodevelopment; neurotoxic; offspring; perfluorohexane; perfluorooctane sulfonate; postnatal; pregnant; prenatal; prenatal exposure; surfactant; toxicant; uptake; visual memory; visual motor; waist circumference

DESCRIPTION (provided by applicant): PFCs are synthetic chemicals used as surfactants and in surface protection, including stain-resistant products (e.g., carpets and fabrics), nonstick coatings, and food packaging. PFCs are ubiquitous and persistent in the environment and in human tissue. Though present in the environment for decades, PFCs are relatively new compounds of interest with respect to health outcomes and there is mounting evidence from animal and human studies suggesting that they may be developmental toxicants. The primary aim of the proposed research is to investigate the association of prenatal PFC exposure with growth and development in children. We will measure levels of four perfluorinated compounds - perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate (PFHxS), and perfluorononanoate (PFNA) - in prenatal maternal plasma collected in early gestation and estimate associations with fetal and infant somatic growth, childhood adiposity and metabolic outcomes such as serum cholesterol and insulin resistance, and neurodevelopment, including cognition and behavior. We will examine associations of PFCs with prenatal maternal and neonatal thyroid hormone levels and explore thyroid function as an underlying pathway for PFC-related associations with growth and neurodevelopment. We will also measure postnatal PFCs in offspring at age 7 to explore their contribution to these outcomes independent of prenatal exposure. We will investigate these aims in Project Viva, a large, well-characterized longitudinal pre-birth cohort of mothers recruited 1999-2002 during pregnancy (approximately 1,700 have archived early pregnancy plasma samples available for PFC analysis) and their offspring (approximately 610 have archived postnatal blood samples available for PFC analysis) followed from birth through age 7 years. We will estimate associations using multivariable regression, controlling for a wide range of covariates. This will be the largest study to date to assess the effect of prenatal PFCs on childhood growth and development the first study to account for prenatal and postnatal PFCs. This highly cost-effective investigation will benefit from the use of a well-characterized population assessed longitudinally since early pregnancy for whom a wealth of information on risk factors for adverse child development has already been collected. Recruitment of pregnant mothers during 1999-2002 coincides with the period of peak PFC emissions, enhancing our power to detect exposure effects. Results will further our understanding of the impact of prenatal and postnatal exposure to PFCs on growth and development during the prenatal and early childhood period. This is a major public health concern given the ubiquity and persistence of these chemicals in the environment and in humans and their potential role as developmental toxicants. PUBLIC HEALTH RELEVANCE: Polyfluoroalkyl chemicals (PFCs) are widely used in industrial and consumer products, such as food packaging, and stain-resistance coatings for carpet and furniture, yet little is known about their effect on human health. This study will be an important contribution to the literature necessary for informing the public about the potential hazard associated with prenatal and postnatal PFCs on fetal and childhood growth and neurodevelopment.

描述（由申请人提供）：PFC是合成化学物质，用作表面活性剂和表面保护，包括耐污渍的产品（例如地毯和织物），不粘 涂料和食物包装。 PFC在环境和人体组织中无处不在且持久。尽管数十年来存在于环境中，但PFC在健康状况方面是相对较新的化合物，并且动物和人类研究中有越来越多的证据表明它们可能是发展性有毒物质。拟议的研究的主要目的是调查产前PFC暴露与儿童的增长和发育的关联。 We will measure levels of four perfluorinated compounds - perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate (PFHxS), and perfluorononanoate (PFNA) - in prenatal maternal plasma collected in early gestation and estimate associations with fetal and infant somatic growth,儿童期肥胖和代谢结果，例如血清胆固醇和胰岛素抵抗以及神经发育，包括认知和行为。我们将检查PFC与产前母体和新生儿甲状腺激素水平的关联，并探索甲状腺功能作为与PFC相关的与生长和神经发育的关联的潜在途径。我们还将在7岁的后代中测量产后PFC，以探索它们对这些结果与产前暴露无关的结果。我们将在Viva Project Viva中进行调查，这是一个大型，良好的纵向纵向出生前的同类，在怀孕期间招募了1999 - 2002年招募的母亲（大约有1,700个已存档的怀孕早期血浆样本可用于PFC分析），并且后代大约有610个（610个以用于PFC分析）的后代（有610个已归类为PFC分析）。我们将使用多变量回归估算关联，以控制各种协变量。这将是评估产前PFC对儿童增长和发展的影响的最大研究，这是第一个考虑产前和产后PFC的研究。自怀孕早期以来，对纵向评估的良好表征的人群的使用将受益于这种高度成本效益的调查，该人口已经收集了大量有关不良儿童发展危险因素的信息。 1999 - 2002年期间，孕妇的招募与PFC排放峰值的时期一致，从而增强了我们检测暴露效应的能力。结果将进一步了解我们对PFC在产前和幼儿期间对PFC的产前和产后暴露对生长和发育的影响。鉴于这些化学物质在环境和人类及其作为发展毒物的潜在作用中，这是一个主要的公共卫生问题。 公共卫生相关性：多氟烷基化学物质（PFC）广泛用于工业和消费产品，例如食品包装和用于地毯和家具的防污涂料，但对它们对人类健康的影响知之甚少。这项研究将是 对向公众通报与产前和产后PFC有关胎儿和儿童生长和神经发育相关的潜在危害所必需的文献的重要贡献。