PRENATAL EXPOSURE TO MANGANESE AND ADHD-LIKE BEHAVIORS IN CHILDHOOD

产前接触锰和儿童时期出现多动症样行为

• 批准号: 7772271
• 负责人: SHARON K. SAGIV
• 金额: $ 5.09万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7772271
• 关键词: Archives; Attention; Attention deficit hyperactivity disorder; Behavior; Behavior Disorders; Behavior assessment; Birth; Blood specimen; Characteristics; Child; Child Development; Childhood; Development; Diagnosis; Environmental Risk Factor; Etiology; Evaluation; Exposure to; General Population; Impulsivity; Incidence; Infant; Intelligence; Joints; Lead; Life; Manganese; Massachusetts; Measures; Medical Records; Metals; Mothers; Neonatal; Neurotoxins; Nutrient; Parents; Pharmaceutical Preparations; Play; Polychlorinated Biphenyls; Population; Prospective Studies; Psychometrics; Reporting; Research; Research Personnel; Risk; Risk Factors; Role; School-Age Population; System; Testing; Umbilical Cord Blood; Wechsler Scales; cohort; inattention; insight; neurobehavior; neurobehavioral; performance tests; postnatal; prenatal; prenatal exposure; public health relevance; superfund site; synergism; teacher

DESCRIPTION (provided by investigator): The etiology of Attention Deficit Hyperactivity Disorder (ADHD) is poorly understood and identification of modifiable environmental risk factors is important for reducing its incidence. Manganese (Mn) is both an essential nutrient and, at high levels, a potential neurotoxicant to which the general population is commonly exposed. The primary aim of the proposed research is to investigate the association of prenatal Mn with behaviors associated with ADHD among infants using the Neonatal Behavioral Assessment Scale (NBAS), and among school-aged children (median=8 years) using three assessments: (1) clinically diagnosed ADHD; (2) behaviors associated with ADHD assessed with the Conners' Rating Scale for Teachers: and (3) behaviors associated with ADHD measured with formal psychometric tests, including the Neurobehavioral Evaluation System 2 Continuous Performance Test, and components of the Wechsler Intelligence Scale for Children-Third Edition. We will also investigate potential synergism between Mn and lead (Pb) on risk for ADHD. The study will be conducted among a birth cohort of 788 infants born between 1993 and 1998 to mothers residing adjacent to a metal- and PCB-contaminated harbor and Superfund site in New Bedford, Massachusetts. Mn is measured in archived cord blood samples. Associations will be estimated with multivariable regression, controlling for a wide range of covariates. The proposed study is the largest U.S. study to date to assess the effect of prenatal Mn on subsequent neurobehavior in children and will benefit from the use of a well characterized population whose development has been assessed longitudinally since birth and for whom a wealth of information on risk factors for adverse child development is available. Results will provide important insight into the role of Mn as a potentially remediable risk factor for common behavioral disorders such as ADHD. PUBLIC HEALTH RELEVANCE: Manganese (Mn) is a naturally occurring metal which is both an essential nutrient, and potential neurotoxicant. This study will investigate the association between prenatal Mn and childhood neurobehavioral development, particularly ADHD-related behavior. Our findings will provide important insight into the role of Mn as potentially remediable risk factor for this increasingly common and costly behavioral disorder of childhood.

描述（由研究者提供）：人们对注意力缺陷多动障碍 (ADHD) 的病因知之甚少，识别可改变的环境风险因素对于降低其发病率非常重要。锰 (Mn) 既是一种必需营养素，在高含量时又是普通人群普遍接触的潜在神经毒物。拟议研究的主要目的是使用新生儿行为评估量表 (NBAS) 调查婴儿中产前 Mn 与 ADHD 相关行为的关系，并使用三种评估方法调查学龄儿童（中位数 = 8 岁）中的产前 Mn 与 ADHD 相关行为的关系：(1 ) 临床诊断的多动症； (2) 通过康纳斯教师评定量表评估与 ADHD 相关的行为；以及 (3) 通过正式心理测试测量与 ADHD 相关的行为，包括神经行为评估系统 2 连续表现测试和韦克斯勒儿童智力量表的组成部分-第三版。我们还将研究锰和铅 (Pb) 在 ADHD 风险方面的潜在协同作用。该研究将在 1993 年至 1998 年间出生的 788 名婴儿中进行，这些婴儿的母亲居住在马萨诸塞州新贝德福德受金属和多氯联苯污染的港口和超级基金站点附近。锰是在存档的脐带血样本中测量的。将通过控制大范围协变量的多变量回归来估计关联性。这项拟议的研究是迄今为止美国规模最大的研究，旨在评估产前锰对儿童随后神经行为的影响，并将受益于使用特征明确的人群，这些人群的发育自出生以来就得到了纵向评估，并获得了丰富的风险信息儿童发育不良的因素是可用的。结果将为了解锰作为常见行为障碍（如多动症）的潜在可治愈危险因素的作用提供重要见解。公众健康相关性：锰 (Mn) 是一种天然存在的金属，既是必需营养素，又是潜在的神经毒物。本研究将调查产前锰与儿童神经行为发育（特别是多动症相关行为）之间的关联。我们的研究结果将为了解锰作为这种日益常见且代价高昂的儿童行为障碍的潜在可补救风险因素的作用提供重要见解。