Prenatal exposure to phthalates and neurodevelopment in children

产前接触邻苯二甲酸盐与儿童神经发育

• 批准号: 9168535
• 负责人: SHARON K. SAGIV
• 金额: $ 7.85万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9168535
• 关键词: 7 year old; Accounting; Adolescence; Age; Animals; Anxiety; Attention; Behavior; Behavioral; Biological; Birth; Brain; Breathing; Chemicals; Child; Childhood; Chronic; Cognition; Cognitive; Comprehension; Consumer Product Safety; Cosmetics; Data; Data Quality; Dermal; Development; Diet; Endocrine Disruptors; Environment; Epidemiologic Studies; Exposure to; Fetus; Food Packaging; Health; Homeostasis; Hour; Human; Hyperactive behavior; Literature; Measures; Mediating; Medical Device; Memory impairment; Methods; Mothers; Nature; Nervous system structure; Neurosecretory Systems; Neurotoxins; Outcome; Parents; Pathway interactions; Performance; Placenta; Plasticizers; Population; Pregnancy; Public Health; Recruitment Activity; Reporting; Research; Rodent; Salinum; Sample Size; Sampling; Short-Term Memory; Statistical Models; Testing; Thyroid Hormones; Time; Toxic effect; Toy; Urine; Work; absorption; age group; androgenic; base; building materials; chemical group; cognitive development; cohort; design; early adolescence; early life exposure; executive function; exposed human population; externalizing behavior; flexibility; hazard; memory process; neurodevelopment; neuropsychological; offspring; personal care products; phthalates; policy implication; prenatal; prenatal exposure; processing speed; resilience; social cognition; teacher; urinary

ABSTRACT Phthalates are synthetic chemicals used in personal care products and in flexible plastic products. Along with their metabolites, phthalates are rapidly excreted in humans with half-lives of 5-24 hours. Exposure to phthalates is ubiquitous because of their widespread use and their ability to leach easily into the environment. Phthalates are endocrine-disrupting chemicals that may interfere with neuroendocrine pathways involved in neurodevelopment, including anti-androgenic activity and thyroid hormone homeostasis. The prenatal period is a particularly sensitive target for phthalate exposure due to rapid brain development. Previous studies of phthalates and neurodevelopment are limited by small sample size, cross-sectional design, and limited data on neurodevelopment. The primary objective of the proposed research is to investigate the association of prenatal exposure to phthalates with cognitive and behavioral development in childhood and adolescence. We will examine these relationships in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS), a large, well-characterized longitudinal pre-birth cohort of mothers recruited 1999-2000 during pregnancy and their offspring. We will analyze existing data on maternal phthalate levels, measured twice during pregnancy (~13 and 26 weeks), in relation to the cohort's extensive data on neurodevelopment measured from age 7 years until adolescence for 336 children with exposure and outcome data. We will examine associations with the following outcomes: (1) general cognition, (2) executive function, (3) attention problems, externalizing behaviors and internalizing behaviors, and (4) social cognition. This study will take advantage of the CHAMACOS cohort's longitudinal data collected on teacher- and parent-rated scales as well as objective, performance-based tests. Additionally, this will be the first study to examine associations of phthalates with neurodevelopmental measures in adolescence, a critical time for manifestations of early life exposure effects. Results of this study, which will further our understanding of the long-term impact of early-life exposure to phthalates on neurodevelopment, have important policy implications given that widespread exposure to these chemicals in personal care products is modifiable and alternatives may be available during sensitive time windows, such as pregnancy.

抽象的 邻苯二甲酸盐是用于个人护理产品和柔性塑料产品中的合成化学物质。以及 他们的代谢产物，邻苯二甲酸盐在人类中迅速排泄，半衰期为5-24小时。接触 邻苯二甲酸盐无处不在，因为它们的广泛使用和容易进入环境的能力。 邻苯二甲酸酯是内分泌干扰化学物质，可能会干扰涉及的神经内分泌途径 神经发育，包括抗雄激素活性和甲状腺激素稳态。产前时期是 由于脑发育迅速，邻苯二甲酸盐暴露的靶标特别敏感。先前的研究 邻苯二甲酸酯和神经发育受到较小样本量，横截面设计的限制，并且对 神经发育。拟议研究的主要目的是研究产前的关联 在儿童期和青春期内具有认知和行为发展的邻苯二甲酸盐。我们将 在萨利纳斯的母亲和子女的健康评估中心检查这些关系 （Chamacos），一个大型，良好的纵向纵向前生前群体，在1999 - 2000年招募 怀孕及其后代。我们将分析孕产妇邻苯二甲酸盐水平的现有数据，测量两次 在怀孕期间（约13周和26周），与该队列有关神经发育的广泛数据有关 从7岁到青春期的336名患有暴露和结果数据的儿童的衡量。我们将 检查与以下结果的关联：（1）一般认知，（2）执行功能，（3）注意 问题，外在行为和内在行为以及（4）社会认知。这项研究将进行 Chamacos队列的纵向数据的优势也是在教师和父母评分量表上收集的 作为客观的，基于绩效的测试。此外，这将是首次研究关联的研究 在青春期中采用神经发育测量的邻苯二甲酸盐，这是早期生命的关键时期 暴露效果。这项研究的结果，这将进一步了解早期生活的长期影响 在神经发育中暴露于邻苯二甲酸盐，鉴于广泛的影响，具有重要的政策意义 在个人护理产品中接触这些化学物质是可修改的，并且可以在 敏感的时间窗，例如怀孕。