PRENATAL EXPOSURE TO METHYLMERCURY AND CHILDHOOD BEHAVIOR

产前接触甲基汞和儿童行为

• 批准号: 7623106
• 负责人: SHARON K. SAGIV
• 金额: $ 8.17万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-13 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7623106
• 关键词: Attention; Attention deficit hyperactivity disorder; Behavior; Behavior assessment; Behavioral; Biological Markers; Birth; Brain; Child; Childhood; Cognitive; Consensus; Consumption; Data; Evaluation; Exposure to; Faeroe Islands; Fishes; Hair; Health Benefit; Infant; Intelligence; Island; Literature; Massachusetts; Measurement; Measures; Methylmercury Compounds; Mothers; Neonatal; Outcome; Parents; Polychlorinated Biphenyls; Postpartum Period; Prospective Studies; Public Health; Reporting; Research; Research Personnel; School-Age Population; Seminal; Sex Characteristics; Seychelles; Source; System; Uncertainty; cohort; hazard; neurobehavior; neurobehavioral; neurodevelopment; performance tests; prenatal; prenatal exposure; prospective; superfund site; teacher

DESCRIPTION (provided by investigator): There is uncertainty about the effect of low-level methylmercury (MeHg) exposure on neurodevelopment. Two seminal studies conducted in the Faroe Islands and the Seychelles Islands of prenatal MeHg exposure report inconsistent conclusions with respect to cognitive and behavioral outcomes. The primary aims of the proposed research are to investigate: 1) the association between prenatal MeHg and attention-associated behaviors among infants using the Neonatal Behavioral Assessment Scale (NBAS); and 2) the association between MeHg and behaviors associated with Attention Deficit Hyperactivity Disorder (ADHD) among school-aged children (median=8 years) using the Conners' Rating Scale for Teachers (CRS-T), the Neurobehavioral Evaluation System 2 (NES2) Continuous Performance Test (CPT), and components of the Wechsler Intelligence Scale for Children-Third Edition (WISC-III). We will also investigate a potential synergistic effect of MeHg and polychlorinated biphenyls (PCBs) on behavior and evaluate gender differences for the MeHg and behavior associations. Finally, we will assess the potential confounding effect of fish consumption on the association between MeHg and behavior. The study will be conducted among a birth cohort of 788 infants born between 1993 and 1998 to mothers residing adjacent to a PCB-contaminated harbor and Superfund site in New Bedford, Massachusetts. MeHg was measured in maternal hair collected at approximately 10 days postpartum. Associations with behavioral outcomes will be estimated with multivariable regression, controlling for a wide range of covariates. Results of this study will build upon the literature on the neurodevelopmental effects of MeHg. This is critical to arriving at consensus in informing the public about the potential hazard of prenatal MeHg exposure, given that the primary source of exposure is fish consumption, which is associated with substantial health benefits, including benefits to neurodevelopment. PROJECT HEALTH RELEVANCE The association between prenatal methylmercury (MeHg) and neurodevelopment is not well understood. This study will be an important contribution to the literature necessary for informing the public about the potential hazard associated with prenatal MeHg exposure, given the apparent benefit of fish consumption on the developing brain.

描述（由研究者提供）：低水平甲基汞 (MeHg) 暴露对神经发育的影响尚不确定。在法罗群岛和塞舌尔群岛进行的两项关于产前甲基汞暴露的开创性研究报告了关于认知和行为结果的不一致结论。拟议研究的主要目的是调查：1）使用新生儿行为评估量表（NBAS）研究产前甲基汞与婴儿注意力相关行为之间的关联； 2) 使用康纳斯教师评定量表 (CRS-T)、神经行为评估系统 2 (NES2) 确定甲基汞与学龄儿童（中位数 = 8 岁）注意力缺陷多动障碍 (ADHD) 相关行为之间的关联) 连续表现测试 (CPT) 以及韦克斯勒儿童智力量表第三版 (WISC-III) 的组成部分。我们还将研究甲基汞和多氯联苯 (PCB) 对行为的潜在协同效应，并评估甲基汞和行为关联的性别差异。最后，我们将评估鱼类消费对甲基汞与行为之间关联的潜在混杂影响。该研究将在 1993 年至 1998 年间出生的 788 名婴儿中进行，这些婴儿的母亲居住在马萨诸塞州新贝德福德受多氯联苯污染的港口和超级基金站点附近。在产后大约 10 天收集的母亲头发中测量了甲基汞。与行为结果的关联将通过多变量回归来估计，控制范围广泛的协变量。这项研究的结果将建立在有关甲基汞神经发育影响的文献的基础上。鉴于接触甲基汞的主要来源是鱼类消费，而鱼类消费与巨大的健康益处（包括对神经发育的益处）相关，因此这对于在告知公众产前甲基汞接触的潜在危害方面达成共识至关重要。项目健康相关性 产前甲基汞 (MeHg) 与神经发育之间的关系尚不清楚。鉴于食用鱼类对发育中的大脑有明显的好处，这项研究将对向公众通报与产前甲基汞暴露相关的潜在危害所必需的文献作出重要贡献。