The neurodevelopmental trajectory of reading: a publicly available multimodal neuroimaging database

阅读的神经发育轨迹：公开的多模式神经影像数据库

• 批准号: 10365931
• 负责人: Vincent L. Gracco
• 金额: $ 6.19万
• 依托单位: HASKINS LABORATORIES, INC.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-05 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10365931
• 关键词: Address; Adolescence; Adolescent; Adult; Affect; Age; Anatomy; Archives; Attention deficit hyperactivity disorder; Awareness; BRAIN initiative; Behavioral; Brain; Brain imaging; Child; Childhood; Code; Cognitive; Collaborations; Communities; Computer Models; Country; Data; Data Set; Data Sources; Databases; Development; Diagnostic; Dimensions; Disabled Persons; Disease; Electroencephalography; Family; Foundations; Functional Magnetic Resonance Imaging; Funding; General Population; Grant; Individual; Individual Differences; Industry Standard; Institutes; International; Investigation; Laboratories; Language; Life; Location; Measures; Medical; Modality; National Institute of Child Health and Human Development; Nature; Neurobiology; Neurocognitive; Neurodevelopmental Disorder; Orthography; Paper; Participant; Pathway interactions; Population Characteristics; Process; Reader; Reading; Reading Disabilities; Reading Disorder; Recording of previous events; Research; Research Personnel; Resolution; Rest; Sample Size; Sampling; Scanning; Semantics; Series; Speech; Statistical Data Interpretation; Strategic Planning; Structure; Text; Twitter; United States National Institutes of Health; aged; base; behavior measurement; brain behavior; brain pathway; cognitive testing; comorbidity; data mining; data structure; experience; functional MRI scan; improved; in vivo; magnetic resonance imaging/electroencephalography; multimodal data; multimodal neuroimaging; multimodality; neural circuit; neuroimaging; neuromechanism; phonology; reading ability; recruit; relating to nervous system; secondary analysis; skills; social media; symposium; theories; university student; young adult

Project Summary (30 lines of text) Reading disability (RD) is the most common neurodevelopmental disorder of childhood, estimated to affect 10- 15% of children of otherwise typically developing children. RD is a life-long disorder with significant difficulties persisting into adolescence and adulthood in several domains. Understanding the key environmental, cognitive and neurobiological bases of reading and disorders is fundamental to improve diagnostics and treatment of reading disabilities. Although much progress has been made on how the neural circuitry for reading depends on reading ability, quantitative analyses of how the brain structure and function underlies reading as a function of age and ability, and their interaction, are still lacking. A number of relevant findings originated from our lab and were supported by a series of NICHD grants. Although we have made significant progress on each of these grants in isolation, we strongly believe that making these datasets available to the scientific community allows for addressing questions that so far remained unanswered and this constitutes the key significance of this proposal. Across studies we used comparable measures at the level of brain and behavior, and given the rich range on age, ability and comorbidity status and the comparability of measures the potential scientific yield from combining these data sets into a unified database is strong. Important neurodevelopmental questions about how component processing in reading changes with experience and their associated brain pathways and how this differs in good and poor readers will be addressable. Moreover, an important longer-term strategic plan for which this project would be a foundation is to involve our collaborators from the U.S and other countries in building upon and extending this database to address reading development across orthographies. The proposed database contains environmental and background data, structural and functional (print/speech localizer tasks) brain measures across age and sensitive cognitive measures of code utilization in word reading, and many other language related measures, that will allow the user to chart key brain/behavior relations. We have collected over 1000 neuroimaging scans from 700 individuals across the age range from 5-30 years old, from preliterate to highly proficient readers. All data will be fully anonymized, stored in the industry standard Brain Imaging Data Structure (BIDS) and uploaded, ultimately within a year after the grant's completion, on OpenNEURO. OpenNEURO is a free and open platform, approved by the NIH brain initiative (https://braininitiative.nih.gov/), for sharing in-vivo neuroimaging data. To increase awareness of the existence of this database, a white paper describing the richness and power of the data will be submitted after all data is uploaded. Additionally, we will inform other reading researcher using existing social media channels (e.g. Haskins twitter feed) and mail channels of conference attendees and other google mail lists.

项目摘要（文本30行） 阅读障碍（RD）是最常见的儿童神经发育障碍，估计会影响10- 15％的儿童通常是通常成长的儿童。 RD是一种终身疾病，有很大的困难 在几个领域持续到青春期和成年。了解关键的环境，认知 阅读和疾病的神经生物学基础是改善诊断和治疗的基础 阅读障碍。尽管关于阅读的神经回路如何取决于 阅读能力，大脑结构和功能如何基础阅读的定量分析 年龄和能力及其互动仍然缺乏。许多相关发现源自我们的实验室， 得到一系列NICHD赠款的支持。尽管我们在每一个方面都取得了重大进展 孤立的赠款，我们坚信使科学界可用这些数据集允许 为了解决迄今为止尚未解决的问题，这构成了这一点的关键意义 提议。在整个研究中，我们在大脑和行为水平上使用了可比的措施，并鉴于富人 年龄，能力和合并症状态以及衡量标准的可比性的范围 将这些数据集结合到统一数据库中很强。关于如何的重要神经发育问题 与经验及其相关的大脑通路的阅读变化中的组件处理以及如何 在良好和贫穷的读者方面有所不同。此外，这是一个重要的长期战略计划 该项目将是一个基础，是要让我们的合作者来自美国和其他国家建设 并扩展该数据库，以解决跨拼字法的阅读开发。 提出的数据库包含环境和背景数据，结构和功能（打印/语音 本地化任务）跨年龄跨年龄和对文字阅读中代码利用的敏感认知度量的大脑测量， 以及许多其他与语言相关的措施，这些措施将使用户能够绘制关键的大脑/行为关系。我们 从5-30岁的年龄范围内的700个人中收集了1000多个神经影像学扫描， 从预先读者到高度熟练的读者。所有数据都将完全匿名，存储在行业标准中 脑成像数据结构（BID）并上传，最终在赠款完成后的一年之内 Openneuro。 Openneuro是一个免费的开放平台，已获得NIH脑倡议的批准 （https://brainitiative.nih.gov/），用于共享体内神经影像学数据。提高对存在的认识 在此数据库中，一份描述数据的丰富性和功能的白皮书将在所有数据均为 上传。此外，我们将使用现有的社交媒体渠道通知其他阅读研究人员（例如 Haskins Twitter提要）和会议参与者和其他Google邮件列表的邮件渠道。