Prenatal and lifetime exposure to pesticides and particulate matter and respiratory health in young adults from the CHAMACOS birth

CHAMACOS 出生后年轻人的产前和终生接触农药和颗粒物以及呼吸系统健康

• 批准号: 10569649
• 负责人: Robert Gunier
• 金额: $ 57.46万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-10 至 2026-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10569649
• 关键词: 21 year old; 7 year old; Absenteeism; Address; Adolescence; Adult; Age; Age Years; Agriculture; Air; Air Pollutants; Air Pollution; Airway Disease; Asthma; Biological; Biological Markers; Birth; California; Cells; Child; Childhood; Childhood Asthma; Cohort Studies; Complex; Cross-Sectional Studies; DNA; DNA Methylation; Data; Data Reporting; Disease; Environment; Environmental Exposure; Epigenetic Process; Epithelial Cells; Ethylenes; Etiology; Exposure to; Family; Future; Genes; Goals; Grant; Growth; Hypersensitivity; Individual; Inflammation; Joints; Life; Link; Longitudinal Studies; Measures; Methylation; Mexican Americans; Morbidity - disease rate; Mothers; Nasal Epithelium; Nose; Occupational; Occupational Exposure; Organophosphates; Outcome; Participant; Particulate Matter; Pathway interactions; Persons; Pesticides; Play; Policies; Predisposition; Pregnancy; Prospective Studies; Pulmonary function tests; Quality of life; Research; Respiratory Disease; Respiratory Signs and Symptoms; Risk; Role; Salinas Valley; Schools; Site; Societies; Spirometry; Structure of mucous membrane of nose; Study of Latinos; Sulfur; Symptoms; Testing; Tissues; Visit; Work; agricultural community; agricultural pesticide; air monitoring; airway inflammation; cohort; cost; design; early life exposure; emerging adult; epigenetic marker; farm worker; fine particles; fungicide; health assessment; methylome; mortality; nasal swab; novel; pesticide exposure; pollutant; potential biomarker; pregnant; prenatal; prospective; pulmonary function; remote sensing; respiratory health; response; urban area; young adult

Abstract In the U.S., there are currently 22.7 million people living with asthma with a large cost to society estimated at $89 billion. Environmental exposures have been identified as playing a role in asthma etiology and lung function growth and the relationship with air pollution exposure is well established in more urban areas. Pesticide exposure has also been related to asthma and decline in lung function in workers. In the Center for the Health Assessment of Mothers And Children Of Salinas (CHAMACOS) Study, a longitudinal study of Latino farmworker families in Salinas California, we observed that early life exposure to several pesticides, as measured by biomarkers or residential proximity to agricultural use, were associated with childhood asthma and poorer lung function at age 7. It is unknown if these relationships persist into adulthood. Few studies have examined the impact of exposure to mixtures of pollutants such as particulate matter and pesticides. Methylation of DNA from nasal cells has been related to asthma and airway inflammation and there is evidence of differential methylation with exposure to pollutants, suggesting a possible link between environmental exposures and respiratory health. The long-term goal of our research is to identify modifiable factors related to respiratory health in a birth cohort that has reached young adulthood. We will leverage the unique CHAMACOS prospective birth cohort study to address these questions. Participants are currently 21 years of age and 500 participants still live near the Salinas Valley, and 250 completed lung function testing at 7 years of age. Our objectives in this proposal are to determine whether early life exposure to pesticides continue to impact their respiratory health in adulthood, identify the relative importance of pesticide and air pollution exposures, periods of susceptibility (prenatal, early life and childhood/adolescence), factors that modify these relationships and potential mechanisms involving the methylation of nasal cells. We hypothesize that higher exposure to pesticides and air pollutants in early life will result in poorer respiratory health and that DNA methylation will be a biomarker of these relationships. We will conduct spirometry testing at 22y and estimate pesticide exposure using California’s unique Pesticide Use Report data for the prenatal, early life (0-3y), childhood/adolescence (4-20y) and recent (previous year) periods. We will estimate exposure to particulate matter air pollution by combining remote sensing and air monitoring data. We will measure methylation in DNA collected from nasal swabs. We will assess whether associations observed in the CHAMACOS cohort between pesticide exposure and respiratory health at 7y persist into early adulthood and determine associations of exposure to a mixture of pesticides and particulate matter with respiratory symptoms, asthma, allergy, and lung function. We will characterize associations of DNA methylation with environmental exposures and respiratory health. In this study, we expect to identify the most important exposures and periods of exposure related to adverse respiratory health. Our findings will help inform future policies related to pesticide use and air quality designed to protect respiratory health.

抽象的 在美国，目前有2270万人患有哮喘，据估计，社会成本很高 为890亿美元。环境暴露已被确定为在哮喘病因和肺中发挥作用 在更多城市地区，功能增长以及与空气污染暴露的关系已得到很好的建立。农药 暴露也与工人的哮喘和肺功能下降有关。在健康中心 评估萨利纳斯（Chamacos）研究的母亲和子女，这是一项拉丁裔农场工人的纵向研究 加利福尼亚州萨利纳斯的家庭，我们观察到早期生命暴露于几种农药，如 生物标志物或居民靠近农业用途，与儿童哮喘和肺部较差有关 7岁时的功能。未知这些关系是否持续到成年。很少有研究检查 暴露于混合污染物（例如特定物质和农药）的影响。 DNA的甲基化 鼻细胞与哮喘和气道感染有关，有甲基化差异的证据 在暴露于污染物的情况下，表明环境暴露与呼吸健康之间可能存在联系。 我们研究的长期目标是确定与呼吸健康有关的可修改因素 成年年轻的队列。我们将利用独特的Chamacos预期出生队列 研究以解决这些问题。参与者目前年龄21岁，还有500名参与者仍生活在附近 萨利纳斯山谷（Salinas Valley）和250个在7岁时完成了肺功能测试。我们在此提案中的目标是 为了确定早期生命暴露于农药是否继续影响其成年后的呼吸健康状况， 确定农药和空气污染暴露的相对重要性，易感性时期（产前，早期 生活和童年/青春期），修改这些关系和潜在机制的因素 鼻细胞的甲基化。我们假设早期较高的农药和空气污染物的接触将会 导致呼吸健康状况较差，而DNA甲基化将成为这些关系的生物标志物。我们将 在22岁时进行肺活量测定，并使用加利福尼亚独特的农药使用估算农药暴露 报告产前，早期（0-3岁），儿童/青春期（4-20岁）和最近（上一年）的数据。 我们将通过结合遥远灵敏度和空气监测来估算特定物质空气污染 数据。我们将测量从鼻拭子收集的DNA中的甲基化。我们将评估协会是否 在Chamacos队列中观察到农药暴露与7岁时的呼吸健康状况之间的观察到早期 成年并确定暴露于农药和特定物质的混合物的关联 呼吸道症状，哮喘，过敏和肺功能。我们将表征DNA甲基化的关联 环境暴露和呼吸健康。在这项研究中，我们希望确定最重要的 与不良呼吸健康有关的暴露和暴露期间。我们的发现将有助于告知未来 与旨在保护呼吸健康的农药使用和空气质量有关的政策。