Fats, Fiber and Osteoarthritis

脂肪、纤维和骨关节炎

• 批准号: 9364179
• 负责人: DAVID Tobin FELSON
• 金额: $ 61.12万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9364179
• 关键词: Affect; American; Animals; Anti-Inflammatory Agents; Anti-inflammatory; Arachidonic Acids; Arthralgia; Arthritis; Biological; Biological Markers; Cartilage; Clinical; Clinical Trials; Cohort Studies; Data; Data Science; Degenerative polyarthritis; Deterioration; Development; Diabetes Mellitus; Diagnostic radiologic examination; Diet; Diet Modification; Dietary Factors; Dietary Fiber; Disease; Eicosanoids; Elements; Fatty Acids; Fatty acid glycerol esters; Fiber; Fish Oils; Goals; Heart Diseases; Homologous Gene; Human; Incidence Study; Inflammation; Inflammatory; Intake; Joints; Knee Osteoarthritis; LDL Cholesterol Lipoproteins; Lead; Link; Longitudinal Studies; Low-Density Lipoproteins; Measures; Mediating; Mediator of activation protein; Monounsaturated Fatty Acids; Oils; Oleic Acids; Omega-3 Fatty Acids; Pain; Patients; Persons; Pharmacotherapy; Phenotype; Plasma; Process; Public Health; Rheumatoid Arthritis; Risk; Sampling; Saturated Fatty Acids; Structure; Synovitis; Testing; Therapeutic; Time; Weight; Wheat; Work; base; cardiovascular disorder risk; common treatment; disability; disorder risk; effective therapy; experience; longitudinal human study; mortality; prevent; protective effect; treatment group

Osteoarthritis (OA) is the most common form of arthritis affecting millions of Americans; there is a paucity of effective treatments. Inflammation is critical factor affecting pain in OA and also causing structural deterioration in the joint. Dietary factors can modify inflammation and it is the goal of this project to test evidence regarding specific dietary factors that can affect inflammation and for which there is evidence linking that dietary factor to OA. Among factors to be studied include specific fatty acids whose effects on inflammation differ. Among those to be examined are Omega-3 fatty acids which have anti-inflammatory effects and saturated fatty acids, which can enhance inflammation and have been shown in animal studies to accelerate the development of OA. LDL cholesterol has also been linked to OA in ex vivo human and animal studies and we will also examine its with OA. Circulating fatty acid profiles and LDL have not been assessed for their effects on OA in longitudinal human studies. For dietary fiber, numerous studies have pointed to a protective effect on diabetes, heart disease and even mortality. Dietary fiber may reduce systemic inflammation and reduce weight and in recent work from 2 studies, we have found preliminary evidence that dietary fiber intake reduces risk of knee OA. We want to pursue this finding with more definitive work. The overall goal of the proposed project is to comprehensively and longitudinally evaluate whether circulating fatty acid profiles, LDL and fiber modify the risk of symptomatic knee OA. What ties together these factors is that they are all factors affecting inflammation and all modifiable through dietary alterations, something that is inexpensive and greatly desired by patients. To ask these questions we shall take advantage of data from the MOST cohort study, a longitudinal study of 3,026 persons with or at risk of knee OA evaluated for OA serially over 60 months. Baseline biological samples obtained after an overnight fast will allow us to test the associations of fatty acids, LDL and alkylresorcinol, a biomarker of fiber intake, with incident OA. For each of the dietary measures we shall study the incidence of symptomatic OA which is the phenotype of OA with clinical and public health importance consisting of the combination of pain and radiographic OA. There is already preliminary bench science data supporting the association of the dietary factors we are studying. Positive findings from this project will provide sufficient data to warrant clinical trials testing specific dietary treatments for OA and offering the realistic possibility that dietary modifications may enter the therapeutic armamentarium for OA.

骨关节炎（OA）是影响数百万美国人的关节炎的最常见形式。很少 有效治疗。炎症是影响OA疼痛并引起结构的关键因素 关节恶化。饮食因素可以改变炎症，这是该项目测试的目标 有关可能影响炎症的特定饮食因素的证据 那个饮食因素到OA。要研究的因素包括特定的脂肪酸 炎症不同。在需要检查的欧米茄3脂肪酸中有抗炎 作用和饱和脂肪酸，可以增强炎症，并在动物研究中显示 加速OA的发展。 LDL胆固醇也与体内人类和动物中的OA有关 研究，我们还将使用OA进行研究。尚未评估循环脂肪酸轮廓和LDL 在纵向人类研究中对OA的影响。 对于饮食纤维，许多研究表明，对糖尿病，心脏病甚至 死亡。饮食纤维可以减少全身性炎症并减轻体重，以及最近的两项研究的工作， 我们发现了饮食纤维摄入量降低膝盖OA风险的初步证据。我们想追求这个 通过更确定的工作进行寻找。 拟议项目的总体目标是全面，纵向评估是否是否 循环脂肪酸剖面，LDL和纤维改变了有症状的膝盖OA的风险。将这些联系在一起 因素是，它们都是影响炎症和通过饮食改变的因素，所有因素都可以改变， 这是廉价且非常渴望的东西。要问这些问题，我们将利用 来自最同类研究的数据，这是一项对评估膝关节或有膝关节风险的3,026人的纵向研究 对于OA连续60个月。过夜后获得的基线生物样品将使我们能够测试 脂肪酸，LDL和烷基resorcinol的关联是纤维摄入的生物标志物，与入射OA的关联。每个 在饮食措施中，我们将研究有症状的OA的发生率，这是OA的表型 临床和公共卫生重要性包括疼痛和射线照相OA的组合。 已经有初步的基准科学数据支持我们的饮食因素的关联 正在学习。该项目的积极发现将提供足够的数据以保证临床试验测试 针对OA的特定饮食治疗，并提供了饮食修改可能进入的现实可能性 OA的治疗手臂。