Boston University CCCR

波士顿大学CCCR

• 批准号: 10669159
• 负责人: DAVID Tobin FELSON
• 金额: $ 72.54万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-11 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10669159
• 关键词: Allied Health Profession; Area; Arthritis; Award; Behavioral Sciences; Biological; Biometry; Boston; Clinical; Clinical Research; Cohort Studies; Collaborations; Communities; Complement; Computerized Medical Record; Consensus; Consultations; Databases; Degenerative polyarthritis; Disease; Ensure; Environment; Epidemiologic Methods; Epidemiologist; Epidemiology; Europe; Evaluation; Excision; Faculty; Funding; Goals; Gout; Grant; Health; Influentials; Infusion procedures; Institution; International; Journals; K-Series Research Career Programs; Machine Learning; Medical; Medical Research; Medical center; Methods; Musculoskeletal Diseases; Musculoskeletal Pain; New England; Osteoporosis; Outcome; Pain; Pain Measurement; Paper; Peer Review; Persons; Physical therapy; Privatization; Productivity; Public Health Schools; Publications; Publishing; Research; Research Design; Research Methodology; Research Personnel; Research Project Grants; Resources; Rheumatism; Rheumatology; Risk Factors; Schools; Scleroderma; Spondylarthritis; Talents; Training; Translational Research; United States National Institutes of Health; Universities; Update; clinical center; clinical translation; cohort; design; epidemiology study; improved; innovation; interdisciplinary collaboration; mHealth; machine learning method; medical schools; meetings; member; multidisciplinary; novel; novel strategies; patient oriented; prevent; programs; protocol development; research faculty; statistical service; success; trial planning

OVERALL ABSTRACT The Boston University CCCR will serve as a central resource for clinical research focused mostly on the most common musculoskeletal disorders, osteoarthritis and gout and will also provide research resources for investigator based research in scleroderma, spondyloarthritis, musculoskeletal pain and osteoporosis. Center grant funding has supported 30-35 papers annually in peer reviewed journals, most in the leading arthritis journals and some in leading general medical journals. This center has trained many of the leading clinical researchers in rheumatology throughout the US and internationally, and many of these former trainees have active collaborations with the center. We will include a broad research community and a core group of faculty in this CCCR. The research community's ready access to core faculty and to the sophisticated research methods and assistance they provide will enhance the clinical and translational research of the community and will increase collaborative opportunities for the core faculty and the community. The CCCR updates BU's historical focus on epidemiologic methods to include new approaches to causal inference and adds new methods in machine learning and mobile health. The Research and Evaluation Support Core Unit (RESCU) is the focal point of this CCCR. A key feature is the weekly research (RESCU meetings in which ongoing and proposed research projects are critically evaluated. This feature ensures frequent interactions between clinician researchers, epidemiologists and biostatisticians who are the core members of the CCCR. The RESCU core unit has provided critical support for other Center grants related to rheumatic and arthritic disorders at Boston University, three current R01/U01's; five current NIH K awards (one K24, 3 K23's, one K01), an R03, an NIH trial planning grant (U34), and multiple ACR RRF awards. The overall goal of this center is to carry out and disseminate high-level clinical research informed both by state of the art clinical research methods and by clinical and biological scientific discoveries. Ultimately, we aim either to prevent the diseases we are studying or to improve the lives of those living with the diseases.

全面的 抽象的 波士顿大学 CCCR 将作为临床研究的中心资源，主要关注最 常见的肌肉骨骼疾病、骨关节炎和痛风，还将提供研究资源 基于研究者的硬皮病、脊柱关节炎、肌肉骨骼疼痛和骨质疏松症研究。中心 拨款资助每年在同行评审期刊上发表 30-35 篇论文，其中大部分发表在领先的关节炎领域 期刊和一些领先的普通医学期刊。该中心培养了许多领先的临床 美国和国际各地的风湿病学研究人员，其中许多以前的实习生 积极与中心合作。 我们将在 CCCR 中包括一个广泛的研究社区和一个核心教师团队。研究界的 随时接触核心教师以及他们提供的复杂研究方法和帮助将增强 社区的临床和转化研究，并将增加核心的合作机会 教师和社区。 CCCR 更新了 BU 对流行病学方法的历史重点，以纳入新的方法 因果推理方法，并添加机器学习和移动健康方面的新方法。 研究与评估支持核心单位 (RESCU) 是 CCCR 的重点。一个关键特征是 每周研究（RESCU 会议，对正在进行的和拟议的研究项目进行严格评估。 这一功能确保了临床研究人员、流行病学家和生物统计学家之间的频繁互动 CCCR的核心成员。 RESCU 核心单位为其他中心提供了关键支持 波士顿大学与风湿病和关节炎疾病相关的拨款，当前三个 R01/U01；目前 NIH 五个 K 奖（1 个 K24、3 个 K23、1 个 K01）、一项 R03、一项 NIH 试验计划拨款 (U34) 和多个 ACR RRF 奖项。 该中心的总体目标是开展和传播国家通知的高水平临床研究 最先进的临床研究方法以及临床和生物科学发现。最终，我们的目标是 预防我们正在研究的疾病或改善疾病患者的生活。

项目成果

Development of radiographic classification criteria for hand osteoarthritis: a methodological report (Phase 2).

• DOI: 10.1136/rmdopen-2021-002024
• 发表时间: 2022-03
• 期刊: RMD open
• 影响因子: 6.2
• 作者: Haugen IK;Felson D;Abhishek A;Berenbaum F;Edwards JJ;Herrero Beaumont G;Hermann-Eriksen M;Hill CL;Ishimori M;Jonsson H;Karjalainen T;Leung YY;Maheu E;Mallen CD;Moe RH;Ramonda R;Ritschl V;Stamm TA;Szekanecz Z;van der Giesen FJ;Ritt MJPF;Wittoek R;Kjeken I;Osteras N;van de Stadt LA;Englund M;Dziedzic KS;Marshall M;Bierma-Zeinstra S;Hansen P;Greibrokk E;Smeets W;Kloppenburg M
• 通讯作者: Kloppenburg M

Disease modification in osteoarthritis; pathways to drug approval.

• DOI: 10.1016/j.ocarto.2020.100059
• 发表时间: 2020-06
• 期刊: Osteoarthritis and cartilage open
• 作者: Katz, Jeffrey N;Neogi, Tuhina;Callahan, Leigh F;Block, Joel A;Conaghan, Philip G;Simon, Lee S;Kraus, Virginia Byers;Hochberg, Marc C
• 通讯作者: Hochberg, Marc C

Web Exclusive. Annals On Call - Knee Osteoarthritis: Does the Type of Shoe Matter?

网络独家。

• DOI: 10.7326/a20-0010
• 发表时间: 2021
• 期刊: Annals of internal medicine
• 影响因子: 39.2
• 作者: Centor,RobertM;Felson,DavidT
• 通讯作者: Felson,DavidT

Where are the women 'Heroes and Pillars of Rheumatology'?

“风湿病学的英雄和支柱”女性在哪里？

• DOI: 10.1136/annrheumdis-2021-222047
• 发表时间: 2023
• 期刊: Annals of the rheumatic diseases
• 影响因子: 27.4
• 作者: Dalbeth,Nicola;Neogi,Tuhina
• 通讯作者: Neogi,Tuhina

Is repeat serum urate testing superior to a single test to predict incident gout over time?

• DOI: 10.1371/journal.pone.0263175
• 发表时间: 2022
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Stewart S;Phipps-Green A;Gamble GD;Stamp LK;Taylor WJ;Neogi T;Merriman TR;Dalbeth N
• 通讯作者: Dalbeth N