The Illinois Precision Medicine Consortium (IPMC) All of Us Research Program Site

伊利诺伊州精准医学联盟 (IPMC) All of Us 研究计划网站

• 批准号: 10872859
• 负责人: Habibul Ahsan
• 金额: $ 1206万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10872859
• 关键词: Acceleration; Accounting; Adult; Age; All of Us Research Program; Amber; Area; Arthritis; Automobile Driving; Award; Awareness; Biomedical Research; COVID-19 pandemic; Catchment Area; Cessation of life; Chicago; Childhood; Church; Clinical; Clinical Informatics; Collaborations; Collection; Communities; Community Health; Complex; Computers; Coronary heart disease; Data; Dedications; Dementia; Disease; Education; Electronic Health Record; Electronic Mail; Enrollment; Ensure; Environmental Exposure; Equity; Ethnic Origin; Ethnic Population; Evaluation; Event; Family; Friends; Funding; Genetic; Genomics; Geography; Goals; Graduate Education; Greenland; Hand; Health; Health Personnel; Health Sciences; Health Service Area; Health Technology; Health care facility; Health system; Healthcare; Healthcare Systems; Hour; Human; Illinois; Income; Indiana; Infrastructure; Institution; Internet; Investments; Knowledge; Leadership; Link; Longevity; Malignant Neoplasms; Methods; Minority Groups; Minority-Serving Institution; Modality; Municipalities; Observational epidemiology; Operations Research; Participant; Patients; Pediatrics; Performance; Persons; Physicians; Play; Population; Population Heterogeneity; Positioning Attribute; Precision Health; Prevention; Protocols documentation; Provider; Race; Research; Research Activity; Research Personnel; Residential Facilities; Resources; Role; Rural; Rural Population; Saliva; Schools; Science; Scientist; Services; Site; Source; Stroke; Structure; Students; System; Target Populations; Telephone; Text Messaging; Training; Training Programs; United States; United States National Institutes of Health; Universities; Voice; Work; career; clinical phenotype; clinical research site; cohort; community organizations; community partnership; cultural competence; data exchange; data quality; demographics; digital; digital technology; disability; disparity reduction; empowerment; epidemiology study; equity, diversity, and inclusion; expectation; experience; flexibility; follow-up; health disparity; health equity; human disease; implementation strategy; improved; innovation; insight; interest; interoperability; mHealth; member; metropolitan; outreach; patient population; podcast; population based; population health; precision medicine; programs; racial population; recruit; resilience research; response; skills; suburb; success; synergism; trend; undergraduate education; web site

1.1. ABSTRACT The first 7 years of the All of Us Research Program (AoURP) Illinois Precision Medicine Consortium (IPMC) award has created an impetus for precision health collaboration in Illinois that will leave a positive legacy for decades both locally and nationally. During the first 5 years of enrollment, the IPMC has drawn strength from our institutional differences, varied scientific interests and expertise, broad geographic catchment areas, and diverse patient populations. To date, we have enrolled a cohort of nearly 43,000 participants from Chicago and greater Illinois, accounting for nearly 10% of the core AoURP participants nationwide – exceeding all expectations for diversity through high enrollment (87%) of those underrepresented in biomedical research (UBR), despite a decreasing trend nationally. Through the COVID-19 pandemic, the IPMC has proven that we can evolve and thrive in a new research context, pivoting operationally while ensuring representation. This is important as the AoURP seeks new target populations (i.e., pediatric) and implementation approaches. The experience of leading the AoURP in Illinois has generated insights, knowledge, best practices, new ideas, and partners to continue and build upon our work in Chicago and throughout Illinois. This includes a recognition of the crucial role that authentic and longstanding engagement plays in developing inclusive biomedical research. We now have fully developed (and constantly expanding) clinical and community infrastructure, stakeholder buy-in, and integrated workflows. These will continue to guide IPMC performance and implementation strategies, supported by intentional engagement investment and integrated expertise. We have identified new scientific partnerships at our Health Provider Organizations (HPOs) and MPIs, now including an additional minority serving institution (MSI) with significant UBR engagement expertise. The IPMC offers this proposal, to fulfill or exceed the AoURP requirements for OTA-22-006 Areas of Interest (AOIs). Under the direction of the AoURP and NIH, for AOI 1- Community, Participant and Provider Engagement, Enrollment and Retention, we will work with AoURP leadership and stakeholders nationally and IPMC-wide to engage and recruit a targeted 50,000 diverse core participants in Illinois during the 5-year award period. We plan to recruit at least 85% UBR into the AoURP by leveraging established leadership and frontline teams, infrastructure, workflows, and new engagement partnerships. We will work collectively to achieve the engagement, enrollment, and retention (active and passive) milestones outlined by the AoURP and implement the protocol fully and flexibly as national approaches, milestone priorities, and strategies and priorities evolve. To achieve these aims, the IPMC proposes to maintain our HPO institutional membership (University of Chicago, Northwestern University, University of Illinois Chicago, NorthShore University HealthSystem, and Rush University, with subcontracts at University of Illinois Urbana-Champaign and University of Illinois Peoria) with Dr. Habibul Ahsan serving as the contact PI with MPIs Daviglus, Greenland, Aschebrook, Ho, Shah, Sanders, Pirzada, and Soares. We will also add a crucial engagement partnership with Governors State University, an MSI with Drs. Balthazar and Roberson joining as MPIs. Over the last 5 years, IPMC partners have demonstrated complementary reach into diverse patient populations while balancing key AoURP metrics (UBR engagement, high quality data, enrollment, and retention). We are confident that our 5-year plan will bring significant value to the AoURP, with an engaged and diverse participant population based in Illinois that will ultimately enable discovery and promote equity in the communities we collectively serve and beyond.

1.1。抽象的 我们所有人的前7年（AOURP）伊利诺伊州精密医学 财团（IPMC）奖为伊利诺伊州的Precision Health合作创造了动力 这将在当地和全国范围内留下几十年来的积极遗产。在头五年 入学率，IPMC从我们的机构差异中汲取了强度 兴趣和专业知识，广泛的地理集水区和患者种群。到 日期，我们已经招募了来自芝加哥和大伊利诺伊州的近43,000名参与者的队列， 占全国核心AOURP参与者的近10％ - 超过所有 通过高度入学人数（87％）对多样性的期望（87％） 生物医学研究（UBR）在全国范围内迈出了趋势。通过COVID-19 IPMC大流行证明，我们可以在新的研究环境中发展和繁荣发展， 在确保表示时进行操作旋转。这很重要，因为Aourp寻求新的 目标人群（即儿科）和实施方法。领导 伊利诺伊州的AOURP产生了见解，知识，最佳实践，新想法和合作伙伴 继续并建立我们在芝加哥和整个伊利诺伊州的工作。这包括认可 真实和长期参与在发展包容性的关键作用 生物医学研究。我们现在已经完全发展（并不断扩展）临床，并且 社区基础设施，利益相关者的买入和集成的工作流程。这些将继续 指导IPMC绩效和实施策略，并有意参与支持 投资和综合专业知识。我们已经确定了健康的新科学伙伴关系 提供者组织（HPO）和MPI，现在包括另外少数派服务 具有巨大的UBR参与专业知识的机构（MSI）。 IPMC提供此建议， 满足或超过OTA-22-006兴趣区域（AOIS）的AOURP要求。在 AOURP和NIH的方向，对于AOI 1-社区，参与者和提供商的参与， 入学和保留，我们将在全国范围内与AOURP领导和利益相关者合作 范围内，IPMC在伊利诺伊州参与和招募有针对性的50,000名潜水员核心参与者 5年奖励期。我们计划通过利用至少招募85％的UBR进入AOURP 建立的领导力和前线团队，基础设施，工作流以及新的参与度 伙伴关系。我们将共同努力实现参与，入学和保留 （主动和被动）AOURP概述的里程碑，并充分实施协议 随着国家方法，里程碑的优先事项以及战略和优先事项的进化而灵活。 实现这些目标，IPMC维护我们的HPO机构会员资格的建议 （芝加哥大学，西北大学，伊利诺伊大学芝加哥大学，北岸 大学健康系统和拉什大学，伊利诺伊大学分包合同 Habibul Ahsan博士担任的Urbana-Champaign和伊利诺伊州Peoria大学） 与MPIS Daviglus，Greenland，Aschebrook，Ho，Shah，Sanh，Sanders，Pirzada和Soares联系PI。 我们还将与州长州立大学添加至关重要的参与伙伴关系， 博士。 Balthazar和Roberson以MPI的身份加入。在过去的5年中，IPMC合作伙伴有 在平衡关键AOURP的同时，展示了出现在潜水员患者人群中的完整范围 指标（UBR参与，高质量数据，注册和保留）。我们有信心 我们的5年计划将为AOUR带来巨大的价值，并有参与的潜水员 伊利诺伊州的参与者人口最终将实现发现并促进公平 在社区中，我们共同服务。