Illinois Precision Medicine Consortium

伊利诺伊州精准医学联盟

• 批准号: 10628963
• 负责人: Habibul Ahsan
• 金额: $ 1071.53万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10628963
• 关键词: Illinois; Text; precision medicine; Illinois; Text; precision medicine

1.1 Overview Precision medicine seeks to capitalize on growing capabilities in the areas of genomics, clinical phenotyping, clinical informatics, electronic health record (EHR) availability and interoperability, and mobile health technologies to improve understanding of human health and disease. Improved understanding of the complex interplay of genetic and environmental exposures, beyond those previously available in long-term observational epidemiological research, holds the promise of better prediction, prevention, and treatment of a host of human diseases including coronary heart disease, stroke, numerous cancers, dementing illnesses, arthritis, and other major causes of disability and early death. Internationally, efforts to address the opportunities of precision medicine have led to the assembly of large cohorts in the UK (UK Biobank), the China Kadoorie Biobank, and in a selected sub-population in the US (the Million Veteran Project - MVP). In January 2015, President Obama announced a plan for the Precision Medicine Initiative (PMI) to address this significant scientific opportunity. This is a unified multi-PI application (Drs. Greenland, Ahsan, Daviglus and Winn) from the Illinois Precision Medicine Consortium (IPMC) representing 3 major Chicago-area academic institutions (Northwestern University, University of Chicago, and the University of Illinois at Chicago) and their healthcare provider organization (HPO) partners, in response to OT-PM-18-001, Limited Competition: All of Us Research Program Regional Medical Center Healthcare Provider Organizations (OT2). Our goal is to continue our partnership with the All of Us Research Program (AoURP), to recruit and enroll a diverse patient population, contributing to the overall total of one million or more individuals across all age groups from both sexes, including both healthy people and those with pre-existing diseases (without regard to specific disease type), and to follow them through innovative mobile health technologies, electronic health records (EHR), and health insurance claims data to enable linkage of genetic and environmental exposures with a broad array of health outcomes. This consortium brings together the extensive preexisting research resources across the 3 academic institutions, as well as the widespread, yet geographically distinct, service areas of their HPO partners representing numerous ethnically and socioeconomically diverse Chicago and Illinois communities. These longstanding relationships of trust are well established. The IPMC has so far reached and exceeded milestones for organization, participation in national planning, and successful recruitment and logistics. For the OT award period, we will continue to utilize a highly participatory and empowered model of diverse participant engagement and enrollment. The data collected from the geographically and ethnically diverse IPMC population, representing the largest and most diverse urban metropolitan area in the Midwestern United States, will add significant value to the overall AoURP goal of enrolling, retaining, and interacting with 1 million US residents. We have assembled a multidisciplinary team of academic researchers, community partners, and health system leaders in the past year. This application builds upon the collective experience and demonstrated success of the 3 partnering institutions in assembly and retention of large epidemiological cohorts, questionnaire data collection, community-based participatory research, minority health research, EHR linkage for genetic research, and their established and ongoing cross- institution collaborations. For this 5-year project period, IPMC plans to enroll 20,000 full participants each year during Years 1 to 3, 18,000 full participants in Year 4, and 15,000 full participants in Year 5. As such, we will consent, conduct physical measurements, collect biospecimens, and transmit curated data to the AoURP Data and Research Center (DRC; Vanderbilt University) and processed biosamples to the AoURP Biobank (Mayo Clinic), on at least 93,000 people from diverse ethnic, social, and economic backgrounds. Further, we aim to broaden our enrollment from patients in IPMC HPOs (and their affiliates), to include direct volunteers (DV), once this capability becomes technically feasible. To reach enrollment milestones, we will engage HPO staff, patients, and the general community to generate support for and participation in the HPO cohort. We will also engage DV corporate partners, such as Walgreens which is headquartered in Deerfield, IL, to collaborate on implementation of HPO/DV Hybrid strategies. We will continue detailed tracking of success rates, including percentage participation and diversity of participation, and discern the most effective recruitment strategies for each participating HPO. We will also continuously adapt, refine and introduce new approaches to maintain recruitment targets. When available, we will employ mobile technologies as developed by the Technology Coordinating Center, and continuously engage participants to remain connected to the AoURP. In aggregate, the academic institutions, HPOs, and community partners represented in this application provide unparalleled expertise and opportunity to reach a geographically and demographically broad and diverse population that is representative of the US as a whole. The population of the greater Chicago and Illinois area brings a unique opportunity to study common and unique environmental, behavioral and genetic underpinnings of health and disease that can inform the precision medicine of tomorrow.

1.1概述Precision Medicine旨在利用基因组学，临床表型，临床信息学，电子健康记录（EHR）可用性和互操作性以及移动健康技术的发展能力的增长，以提高对人类健康和疾病的了解。除了先前在长期观察性流行病学研究中可用的遗传和环境暴露的复杂相互作用之外，人们对复杂的相互作用的理解有望得到更好的预测，预防，预防和治疗许多人类疾病，包括冠心病，中风，疾病，许多癌症，痴呆的疾病，关节炎，关节炎以及其他主要原因和早期死亡。在国际上，解决精确医学机会的努力导致了英国（英国生物库），中国kadoorie生物库以及美国选定的子人口（百万退伍军人项目-MVP）的大型人群组装。 2015年1月，奥巴马总统宣布了《精密医学计划》（PMI）的计划，以解决这一重要的科学机会。 这是伊利诺伊州精确医学联盟（IPMC）（IPMC）的一个统一的多PI申请（Greenland，Ahsan，Daviglus和Winn博士），代表3个芝加哥 - 地区学术机构（西北大学，芝加哥大学，芝加哥大学，伊利诺伊大学芝加哥大学和芝加哥大学）及其医疗保健提供者组织（HPO）竞争：区域医疗中心医疗保健提供者组织（OT2）。 Our goal is to continue our partnership with the All of Us Research Program (AoURP), to recruit and enroll a diverse patient population, contributing to the overall total of one million or more individuals across all age groups from both sexes, including both healthy people and those with pre-existing diseases (without regard to specific disease type), and to follow them through innovative mobile health technologies, electronic health records (EHR), and health insurance claims data to enable linkage of genetic以及环境暴露，具有广泛的健康成果。该财团汇集了整个三个学术机构的广泛的研究资源，以及其HPO合作伙伴的广泛但地理上不同的服务领域，这些服务领域代表了许多种族和社会经济上多样化的芝加哥和伊利诺伊州社区。这些长期存在的信任关系已建立。 到目前为止，IPMC已经达到了组织，参与国家计划以及成功招聘和物流的里程碑。在OT奖励期间，我们将继续利用一种高度参与和有能力的参与者参与和入学模型。从地理和种族多样化的IPMC人群中收集的数据，代表美国中西部的最大，最多样化的城市都市地区，将为入学，保留和与100万美国居民互动的总体AOURP目标增添重要价值。在过去的一年中，我们组建了一个由学术研究人员，社区合作伙伴和卫生系统领导者组成的多学科团队。该申请基于集体经验，并证明了三个合作机构在大型流行病学同伙，问卷数据收集，基于社区的参与式研究，少数族裔健康研究，基因研究的EHR链接及其既定和持续的跨机构合作中取得了成功。 For this 5-year project period, IPMC plans to enroll 20,000 full participants each year during Years 1 to 3, 18,000 full participants in Year 4, and 15,000 full participants in Year 5. As such, we will consent, conduct physical measurements, collect biospecimens, and transmit curated data to the AoURP Data and Research Center (DRC; Vanderbilt University) and processed biosamples to the AoURP Biobank (Mayo Clinic), on at least来自不同种族，社会和经济背景的93,000人。此外，我们旨在扩大IPMC HPO（及其分支机构）患者的入学率，包括直接志愿者（DV），一旦这种能力在技术上可行。为了达到入学里程碑，我们将与HPO员工，患者和一般社区互动，为HPO队列提供支持和参与。我们还将与总部位于伊利诺伊州迪尔菲尔德的Walgreens等DV Corporate Partners进行合作，以合作实施HPO/DV混合策略。我们将继续详细介绍成功率，包括参与百分比和参与的多样性，并辨别每个参与HPO的最有效招聘策略。我们还将不断适应，完善并引入新的方法来维护招聘目标。如果有的话，我们将采用由技术协调中心开发的移动技术，并不断吸引参与者与AOURP保持联系。总体而言，本申请中代表的学术机构，HPO和社区合作伙伴提供了无与伦比的专业知识和机会，以达到代表整个美国的地理和人口范围和多样化的人口广泛和多样化的人群。大芝加哥和伊利诺伊州地区的人口为研究健康的共同环境，行为和遗传基础提供了独特的机会 可以告知明天的精确药物的疾病。