Boston University CCCR

波士顿大学CCCR

基本信息

批准号：
10017004
负责人：
DAVID Tobin FELSON
金额：
$ 72.54万
依托单位：
BOSTON UNIVERSITY MEDICAL CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-11 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10017004
关键词：
Allied Health Profession Area Arthritis Award Behavioral Sciences Biological Biometry Boston Clinical Clinical Research Cohort Studies Collaborations Communities Complement Computerized Medical Record Consensus Consultations Databases Degenerative polyarthritis Disease Ensure Environment Epidemiologic Methods Epidemiologist Epidemiology Europe Evaluation Excision Faculty Funding Goals Gout Grant Health Influentials Infusion procedures Institutes Institution International Journals K-Series Research Career Programs Machine Learning Medical Medical Research Medical center Methods Musculoskeletal Diseases Musculoskeletal Pain New England Osteoporosis Outcome Pain Paper Peer Review Persons Physical therapy Privatization Productivity Public Health Schools Publications Publishing Research Research Design Research Methodology Research Personnel Research Project Grants Resources Rheumatism Rheumatoid Arthritis Rheumatology Risk Factors Schools Scleroderma Spondylarthritis Talents Training Translational Research United States National Institutes of Health Universities Update base clinical center cohort design epidemiology study faculty community faculty research improved innovation interdisciplinary collaboration mHealth machine learning method medical schools meetings member multidisciplinary novel novel strategies patient oriented prevent programs protocol development statistical service success

项目摘要

OVERALL ABSTRACT The Boston University CCCR will serve as a central resource for clinical research focused mostly on the most common musculoskeletal disorders, osteoarthritis and gout and will also provide research resources for investigator based research in scleroderma, spondyloarthritis, musculoskeletal pain and osteoporosis. Center grant funding has supported 30-35 papers annually in peer reviewed journals, most in the leading arthritis journals and some in leading general medical journals. This center has trained many of the leading clinical researchers in rheumatology throughout the US and internationally, and many of these former trainees have active collaborations with the center. We will include a broad research community and a core group of faculty in this CCCR. The research community's ready access to core faculty and to the sophisticated research methods and assistance they provide will enhance the clinical and translational research of the community and will increase collaborative opportunities for the core faculty and the community. The CCCR updates BU's historical focus on epidemiologic methods to include new approaches to causal inference and adds new methods in machine learning and mobile health. The Research and Evaluation Support Core Unit (RESCU) is the focal point of this CCCR. A key feature is the weekly research (RESCU meetings in which ongoing and proposed research projects are critically evaluated. This feature ensures frequent interactions between clinician researchers, epidemiologists and biostatisticians who are the core members of the CCCR. The RESCU core unit has provided critical support for other Center grants related to rheumatic and arthritic disorders at Boston University, three current R01/U01's; five current NIH K awards (one K24, 3 K23's, one K01), an R03, an NIH trial planning grant (U34), and multiple ACR RRF awards. The overall goal of this center is to carry out and disseminate high-level clinical research informed both by state of the art clinical research methods and by clinical and biological scientific discoveries. Ultimately, we aim either to prevent the diseases we are studying or to improve the lives of those living with the diseases.

全面的抽象的波士顿大学 CCCR 将作为临床研究的中心资源，主要关注最常见的肌肉骨骼疾病、骨关节炎和痛风，还将提供研究资源基于研究者的硬皮病、脊柱关节炎、肌肉骨骼疼痛和骨质疏松症研究。中心拨款资助每年在同行评审期刊上发表 30-35 篇论文，其中大部分发表在领先的关节炎领域期刊和一些领先的普通医学期刊。该中心培养了许多领先的临床美国和国际各地的风湿病学研究人员，其中许多以前的实习生积极与中心合作。我们将在 CCCR 中包括一个广泛的研究社区和一个核心教师团队。研究界的随时接触核心教师以及他们提供的复杂研究方法和帮助将增强社区的临床和转化研究，并将增加核心的合作机会教师和社区。 CCCR 更新了 BU 对流行病学方法的历史重点，以纳入新的方法因果推理方法，并添加机器学习和移动健康方面的新方法。研究与评估支持核心单位 (RESCU) 是 CCCR 的重点。一个关键特征是每周研究（RESCU 会议，对正在进行的和拟议的研究项目进行严格评估。这一功能确保了临床研究人员、流行病学家和生物统计学家之间的频繁互动 CCCR的核心成员。 RESCU 核心单位为其他中心提供了关键支持波士顿大学与风湿病和关节炎疾病相关的拨款，当前三个 R01/U01；目前 NIH 五个 K 奖（1 个 K24、3 个 K23、1 个 K01）、一项 R03、一项 NIH 试验计划拨款 (U34) 和多个 ACR RRF 奖项。该中心的总体目标是开展和传播国家通知的高水平临床研究最先进的临床研究方法以及临床和生物科学发现。最终，我们的目标是预防我们正在研究的疾病或改善疾病患者的生活。