MRI-Guided Cardiac Focused Ultrasound Ablation

MRI 引导心脏聚焦超声消融

基本信息

批准号：
8495396
负责人：
VIOLA RIEKE
金额：
$ 23.88万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-04-01 至 2015-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8495396
关键词：
Abdomen Ablation Address Affect Anatomy Animal Model Animals Area Arrhythmia Brain Breast California Cardiac Cardiac ablation Cardiology Catheters Characteristics Chest Clinical Conflict (Psychology)Coupled Deposition Development Electrical Engineering Ethanol Excision FDA approved Faculty Focused Ultrasound Therapy Frequencies Funding Goals Grant Health Care Costs Heart Heart Neoplasms Heating Hypertrophic Cardiomyopathy Image In Vitro Investigation Kidney Left Ventricular Outflow Obstruction Lesion Life Expectancy Liver Lung Magnetic Resonance Magnetic Resonance Imaging Malignant neoplasm of prostate Maps Measurement Mentors Methods Monitor Morbidity - disease rate Motion Myocardial Myocardial tissue Myocardium Obstruction Operative Surgical Procedures Organ Patient Care Patients Performance Phase Physiology Positioning Attribute Preclinical Testing Procedures Prostate Protons Puncture procedure Radiofrequency Interstitial Ablation Radiology Specialty Reproducibility Research Resolution Safety San Francisco Skin Skin Tissue Structure Surgical incisions Symptoms System Techniques Technology Temperature Testing Therapeutic Thermal Ablation Therapy Thermometry Time Tissues Ultrasonic Therapy Ultrasonic Transducer Ultrasonography Universities Uterine Fibroids Work alternative treatment base bioimaging career clinical application design evaluation/testing heart motion heart rhythm in vivo innovation interdisciplinary collaboration malignant breast neoplasm mortality next generation reconstruction respiratory success volunteer

项目摘要

The long-term goal of this project is to develop a noninvasive treatment for hypertrophic obstructive cardiomyopathy (HOCM). Focused ultrasound (FUS) is a promising technique for noninvasive thermal ablation. The effort proposed here addresses the main technical challenges to using focused ultrasound therapy in the heart. Specifically, we aim to 1) evaluate the efficacy of magnetic resonance (MR) guided phased array focused ultrasound (FUS) therapy to non-invasively ablate the myocardium, including strategies to target the heart in the presence of beam path obstruction by ribcage and lungs and to synchronize the ablation to the rhythm of the heart, 2) develop robust real-time targeting and temperature monitoring in the heart using magnetic resonance imaging, and 3) perform initial testing and evaluation ofthe system. My immediate career goal is to develop the necessary FUS ablation and MR imaging strategies to make MRguided FUS ablation a noninvasive alternative for the treatment of HOCM. During the mentored phase, I have participated in interdisciplinary collaboration between the Departments of Radiology, Cardiology, and Electrical Engineering at Stanford University. I was able to gain an understanding of cardiac physiology and ofthe principles of therapeutic ultrasound, in addition to further developing my expertise in cardiac magnetic resonance imaging and MR-thermometry. I have accepted a faculty position at University of California San Francisco in the Department of Radiology and Biomedical Imaging where I can independently research and develop MR-guided focused ultrasound techniques with potential clinical applications. My long-term career goal is to continually contribute to the field of MR-guided focused ultrasound therapy and to make a fundamental impact on patient care_by exploring new, less invasive treatment options.

该项目的长期目标是开发肥厚性阻塞性的无创治疗方法心肌病（HOCM）。聚焦超声（FUS）是无创热的有前途的技术消融。这里提出的努力解决了使用重点超声的主要技术挑战心脏的治疗。具体而言，我们的目的是1）评估引导的磁共振（MR）的功效分阶段阵列聚焦超声（FUS）疗法以非侵入性消融心肌，包括在胸腔和肺部存在梁路径阻塞的情况下，靶向心脏的策略同步烧蚀心脏的节奏，2）发展实时靶向和温度可靠使用磁共振成像在心脏中进行监测，3）进行初始测试和评估系统。我的直接职业目标是制定必要的FUS消融和MR成像策略，以使MRGUIDERDIEND FUS消融是一种无创替代方案，用于治疗HOCM。在指导阶段，我已经参加了放射学，心脏病学部门之间的跨学科合作斯坦福大学电气工程。我能够了解心脏生理学和除了进一步发展我的心脏磁性专业知识外，治疗性超声原理共振成像和MR热度计。我已经接受了加利福尼亚大学SAN的教师职位放射学和生物医学成像系的弗朗西斯科，我可以独立研究和开发具有潜在临床应用的MR指导集中的超声技术。我的长期职业目标是不断为MR引导集中的超声疗法的领域做出贡献，并做一个对患者护理的基本影响探索新的，不太侵入性的治疗方案。