MRI-Guided Cardiac Focused Ultrasound Ablation

MRI 引导心脏聚焦超声消融

基本信息

批准号：
8052730
负责人：
VIOLA RIEKE
金额：
$ 9.18万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-04-01 至 2012-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8052730
关键词：
Abdomen Ablation Address Affect Age Anatomy Animal Model Animals Area Arrhythmia Brain Breast Cardiac Cardiac ablation Cardiology Cardiomyopathies Catheters Characteristics Chest Clinical Conflict (Psychology)Coupled Deposition Development Electrical Engineering Elements Environment Ethanol Excision FDA approved Faculty Focused Ultrasound Therapy Frequencies Funding Goals Grant Health Care Costs Heart Heart Neoplasms Heating Hypertrophic Cardiomyopathy Image In Vitro Investigation Kidney Left Ventricular Outflow Obstruction Lesion Life Life Expectancy Liver Lung Magnetic Resonance Magnetic Resonance Imaging Malignant neoplasm of prostate Maps Measurement Methods Modeling Monitor Motion Myocardial Myocardial tissue Myocardium Obstruction Operative Surgical Procedures Organ Patient Care Patients Performance Phase Physiology Positioning Attribute Preclinical Testing Procedures Prostate Protons Puncture procedure Radiofrequency Interstitial Ablation Radiology Specialty Reproducibility Research Resolution Safety Secure Skin Skin Tissue Structure Surgical incisions Symptoms System Tars Techniques Technology Temperature Testing Thermal Ablation Therapy Thermometry Time Tissues Ultrasonic Therapy Ultrasonic Transducer Universities Uterine Fibroids Work abstracting alternative treatment base career design evaluation/testing heart motion heart rhythm imaging modality in vivo innovation interdisciplinary collaboration malignant breast neoplasm new technology next generation reconstruction respiratory simulation success volunteer

项目摘要

Abstract The long-term goal of this project is to develop a noninvasive treatment for hypertrophic obstructive cardiomyopathy (HOCM). Focused ultrasound (FUS) is a promising technique for noninvasive thermal ablation. The effort proposed here addresses the main technical challenges to using focused ultrasound therapy in the heart. Specifically, we aim to 1) evaluate the efficacy of magnetic resonance (MR) guided phased array focused ultrasound (FUS) therapy to non- invasively ablate the myocardium, including strategies to target the heart in the presence of beam path obstruction by ribcage and lungs and to synchronize the ablation to the rhythm of the heart, 2) develop robust real-time targeting and temperature monitoring in the heart using magnetic resonance imaging, and 3) perform initial testing and evaluation of the system. My immediate career goal is to develop the necessary FUS ablation and MR imaging strategies to make MR-guided FUS ablation a noninvasive alternative for the treatment of HOCM. A unique research environment is avail- able to me through interdisciplinary collaboration between the Departments of Radiology, Cardiology, and Electrical Engineering at Stanford University. This opportunity affords the ability to gain a deep understanding of cardiac physi- ology in addition to further developing my expertise in cardiac magnetic resonance imaging. My career plan includes gaining considerable expertise in the principles of focused ultrasound ablation, including field simulations with finite element models, FUS phantom design, and cardiac MR temperature imaging. My long-term career goal is to secure a tenure-track faculty position so that I can continue to contribute to the field of MR-guided focused ultrasound therapies and to make a fundamental impact on patient care by exploring new, less invasive treatment options.

抽象的该项目的长期目标是开发肥厚性阻塞性心肌病的无创治疗方法（HOCM）。聚焦超声（FUS）是一种无创热消融的有前途的技术。提出的努力这里解决了心脏中使用重点超声疗法的主要技术挑战。具体来说，我们的目标是 1）评估磁共振（MR）引导分阶段焦点超声（FUS）治疗的疗效侵入式心肌，包括在存在梁路径阻塞的情况下针对心脏的策略胸腔和肺部，并同步在心脏节奏上的消融，2）发展强大的实时靶向和使用磁共振成像在心脏中进行温度监测，3）进行初始测试和评估系统。我的直接职业目标是制定必要的FUS消融和MR成像策略来制作 MR引导的FUS消融是一种无创替代方法，可用于治疗HOCM。独特的研究环境可用 - 通过放射学，心脏病学和电气部门之间的跨学科合作，能够给我。斯坦福大学的工程。这个机会使人们能够深入了解心脏物理学除了进一步发展我在心脏磁共振成像方面的专业知识外，Ology。我的职业计划包括在集中超声消融的原理上获得大量专业知识，包括有限的现场模拟元素模型，FUS幻影设计和心脏MR温度成像。我的长期职业目标是确保终身教师职位，以便我可以继续为MR引导的超声疗法做出贡献并通过探索新的，侵入性的治疗选择较少，对患者护理产生根本性的影响。