Developing microwave epiphysiodesis to correct limb length discrepancies

开发微波骨骺固定术以纠正肢体长度差异

• 批准号: 10804031
• 负责人: Christopher L Brace
• 金额: $ 47.33万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-25 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10804031
• 关键词: Abdomen; Ablation; Address; Adoption; Algorithms; Animal Model; Arthritis; Benign; Biological; Bone Growth; Canis familiaris; Chest; Child; Clinical; Curettage procedure; Data; Deformity; Development; Devices; Disease; Distal; Dose Rate; Elements; Ensure; Epiphysial cartilage; Equilibrium; Excision; Family suidae; Femur; Fracture; Frequencies; Gait; Geometry; Growth; Heating; Hemorrhage; Human; Incidence; Infection; Intervention; Joints; Lead; Left; Leg; Length; Limb structure; Malignant - descriptor; Mechanics; Microwave Tumor Ablation; Morbidity - disease rate; Necrosis; Operative Surgical Procedures; Oryctolagus cuniculus; Pain; Patients; Positioning Attribute; Post-Procedural Pain; Procedures; Quality of life; Radiofrequency Interstitial Ablation; Recovery; Reproducibility; Safety; Shapes; System; Techniques; Technology; Temperature; Tissues; Translating; Translations; Traumatic injury; Weight-Bearing state; articular cartilage; bone; chronic back pain; clinical translation; design; direct application; fibula; follow-up; insight; microwave ablation; microwave electromagnetic radiation; novel; pediatric patients; preclinical study; prevent; psychologic; research clinical testing; side effect; stem; tibia; treatment optimization; tumor; tumor ablation; tumor eradication

PROJECT ABSTRACT This project addresses a need for less morbid alternatives to surgical drilling of growth plates in the treatment of limb length discrepancies. Surgical approaches currently require 6 weeks of recovery before weight bearing, which takes a physical and psychological toll on pediatric patients. Surgery has also been associated with complications such as incomplete growth arrest, angular deformity, bleeding, and infection. We hypothesize that microwave ablation – a technology already used for treating malignant and benign tumors throughout the body, including in bones – can be used to disrupt the growth plate with fewer complications and faster return to baseline activity. Preliminary data demonstrates the feasibility delivering microwave energy to create heating in the growth plate when using clinical microwave tumor ablation systems in porcine tibias. This project will focus on developing more optimal devices and techniques for growth plate ablation. Directional antennas will be developed that target microwave energy to the growth plate while minimizing collateral damage. Dynamic positioning and multi-applicator techniques will be used to further refine energy delivery to ensure complete and uniform growth arrest. Finally, the safety and efficacy of the optimized techniques will be compared against the gold-standard of surgical drilling in distal femur, proximal tibia, and fibula. If successful, these developments and studies will form the basis for a novel and exciting treatment for limb length discrepancy in children.

项目摘要 该项目解决了治疗中对生长板手术钻孔的较少病态替代方案的需求 目前，手术方法需要在负重前恢复 6 周， 这对儿科患者的身体和心理造成影响也与手术有关。 并发症，如生长不完全停止、成角畸形、出血和感染。 微波消融——这项技术已经用于治疗恶性和良性肿瘤 身体（包括骨骼）可用于破坏生长板，并发症更少，恢复速度更快 初步数据证明了微波能量产生热量的可行性。 该项目将重点关注在猪胫骨中使用临床微波肿瘤消融系统时的生长板。 开发更优化的生长板消融设备和技术将是。 开发了将微波能量瞄准生长板，同时最大限度地减少附带损害的动态。 定位和多施用器技术将用于进一步完善能量输送，以确保完整 最后，将与优化技术的安全性和有效性进行比较。 如果成功，股骨远端、胫骨近端和腓骨手术钻孔的黄金标准。 发展和研究将为针对肢体长度差异的新颖且令人兴奋的治疗奠定基础 孩子们。