Periodic Contrast-Enhanced CT With HYPR Reconstruction For Ablation Monitoring

周期性增强 CT 与 HYPR 重建用于消融监测

• 批准号: 8528378
• 负责人: Christopher L Brace
• 金额: $ 31.9万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-12 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8528378
• 关键词: Abdomen; Ablation; Address; Adoption; Algorithms; Appearance; Back; Bone neoplasms; Breast; Caring; Contrast Media; Data; Device or Instrument Development; Diagnostic; Dose; Excision; Family suidae; Feedback; Goals; Growth; Heating; Histopathology; Image; Imaging Techniques; Infusion procedures; Intestines; Kidney; Kidney Neoplasms; Liver; Liver neoplasms; Location; Lung; Malignant - descriptor; Measures; Medical; Methods; Modeling; Monitor; Morbidity - disease rate; Normal tissue morphology; Operative Surgical Procedures; Organ; Oryctolagus cuniculus; Pathology; Patients; Physicians; Procedures; Process; Radiation; Recovery; Recurrence; Resolution; Respiratory Diaphragm; Safety; Scanning; Structure; Symptoms; System; Techniques; Technology; Temperature; Testing; Thermal Ablation Therapy; Thermometry; Time; Tissues; Treatment Efficacy; Ultrasonography; United States; Ureter; Woodchuck; X-Ray Computed Tomography; base; bile duct; clinically relevant; effective therapy; follow-up; imaging modality; improved; in vivo; minimally invasive; pressure; prevent; reconstruction; success; tool; tumor; uptake

DESCRIPTION (provided by applicant): Monitoring ablation growth and determining treatment efficacy has become one of the most significant challenges facing thermal tumor ablation. Post-ablation imaging provides no way to monitor the ablation as it develops and current real time strategies fail to provide sufficient spatial resolution of the ablation zone. Without a means to monitor ablation growth, there is no way to prevent unintended thermal damage before it occurs, nor is it possible to alter the course of treatment at the most effective times. In this application, we will begin to develop, optimize and validate a new treatment monitoring technique using technology already available on most scanners using periodic contrast-enhanced computed- tomography (CECT). Periodic CECT will allow monitoring at several time points during the course of treatment while minimizing the total contrast load to the patient. Specifically, we propose to: 1. Measure the uptake and transport of contrast media during thermal ablation Here we will measure the retention or expulsion of contrast media in normal liver and kidney, and two tumor models during ablation. 2. Optimize administration of contrast media and image acquisition parameters for ablation monitoring with periodic CECT In this aim we will characterize periodic CECT during thermal ablation and optimize scan timing, radiation dose and contrast infusion rate using simplex methods. 3. Automate HYPR processing for periodic CECT ablation monitoring. This aim will focus on developing applicator discovery, block matching and registration algorithms to facilitate automated HYPR processing during each imaging sequence. 4. Validate the periodic CECT technique with histopathology and standard CECT In this aim the validity of periodic CECT will be verified by comparing the imaging appearance and histopathology of ablations created in normal liver and kidney, and two tumor models.

描述（由申请人提供）：监测消融生长和确定治疗效果已成为热肿瘤消融面临的最重大挑战之一。启动后成像没有提供在开发消融的方法，并且当前的实时策略无法提供足够的空间分辨率分辨率。没有一种监测消融生长的手段，就无法在发生意外的热损害发生之前，也无法在最有效的时间改变治疗过程。在此应用程序中，我们将使用已定期使用造影剂增强计算机比例（CECT）在大多数扫描仪上使用的技术开始开发，优化和验证一种新的治疗监测技术。定期CECT将允许在治疗过程中多个时间点进行监视，同时最大程度地减少对患者的总造影剂负荷。具体来说，我们建议：1。在热消融过程中测量对比介质的吸收和运输，我们将测量正常肝脏和肾脏中对比介质的保留或驱逐，以及在消融过程中的两个肿瘤模型。 2.优化对比造影介质和图像采集参数，以在此目的中定期进行消融监测，我们将在热消融过程中定期定期CECT，并使用单纯形方法优化扫描时间，辐射剂量和对比度输注率。 3。自动化HYPR处理，以进行周期性烧蚀监测。该目标将着重于开发涂抹器的发现，阻止匹配和注册算法，以促进每个成像序列中自动化的HYPR处理。 4。通过比较在正常肝脏和肾脏中产生的消融的成像外观和组织病理学以及两个肿瘤模型，可以验证具有组织病理学和标准CECT的周期性CECT技术。