Periodic Contrast-Enhanced CT With HYPR Reconstruction For Ablation Monitoring

周期性增强 CT 与 HYPR 重建用于消融监测

• 批准号: 8110637
• 负责人: Christopher L Brace
• 金额: $ 29.58万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-12 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8110637
• 关键词: Ablation; Address; Algorithms; Appearance; Contrast Media; Dose; Growth; Histopathology; Image; Infusion procedures; Kidney; Liver; Measures; Methods; Modeling; Monitor; Patients; Procedures; Process; Radiation; Resolution; Scanning; Techniques; Technology; Thermal Ablation Therapy; Time; Treatment Efficacy; X-Ray Computed Tomography; improved; prevent; reconstruction; success; tumor; uptake

DESCRIPTION (provided by applicant): Monitoring ablation growth and determining treatment efficacy has become one of the most significant challenges facing thermal tumor ablation. Post-ablation imaging provides no way to monitor the ablation as it develops and current real time strategies fail to provide sufficient spatial resolution of the ablation zone. Without a means to monitor ablation growth, there is no way to prevent unintended thermal damage before it occurs, nor is it possible to alter the course of treatment at the most effective times. In this application, we will begin to develop, optimize and validate a new treatment monitoring technique using technology already available on most scanners using periodic contrast-enhanced computed- tomography (CECT). Periodic CECT will allow monitoring at several time points during the course of treatment while minimizing the total contrast load to the patient. Specifically, we propose to: 1. Measure the uptake and transport of contrast media during thermal ablation Here we will measure the retention or expulsion of contrast media in normal liver and kidney, and two tumor models during ablation. 2. Optimize administration of contrast media and image acquisition parameters for ablation monitoring with periodic CECT In this aim we will characterize periodic CECT during thermal ablation and optimize scan timing, radiation dose and contrast infusion rate using simplex methods. 3. Automate HYPR processing for periodic CECT ablation monitoring. This aim will focus on developing applicator discovery, block matching and registration algorithms to facilitate automated HYPR processing during each imaging sequence. 4. Validate the periodic CECT technique with histopathology and standard CECT In this aim the validity of periodic CECT will be verified by comparing the imaging appearance and histopathology of ablations created in normal liver and kidney, and two tumor models.

描述（由申请人提供）：监测消融生长和确定治疗效果已成为热肿瘤消融面临的最重大挑战之一。消融后成像无法监测消融的发展，并且当前的实时策略无法提供消融区域足够的空间分辨率。如果没有监测消融生长的方法，就无法在意外热损伤发生之前防止其发生，也不可能在最有效的时间改变治疗过程。在此应用中，我们将开始开发、优化和验证一种新的治疗监测技术，该技术使用大多数扫描仪上现有的技术，使用定期对比增强计算机断层扫描 (CECT)。定期 CECT 将允许在治疗过程中的多个时间点进行监测，同时最大限度地减少患者的总造影剂负荷。具体来说，我们建议： 1.测量热消融过程中造影剂的摄取和转运在这里，我们将测量消融过程中正常肝脏和肾脏以及两个肿瘤模型中造影剂的保留或排出。 2. 优化造影剂管理和图像采集参数，用于定期 CECT 消融监测 为此，我们将表征热消融期间的定期 CECT，并使用单纯形方法优化扫描时间、辐射剂量和造影剂输注速率。 3. 自动执行 HYPR 处理以进行定期 CECT 消融监测。该目标将重点开发涂抹器发现、块匹配和配准算法，以促进每个成像序列期间的自动化 HYPR 处理。 4.用组织病理学和标准CECT验证定期CECT技术在此目的中，将通过比较正常肝脏和肾脏以及两种肿瘤模型中产生的消融的成像外观和组织病理学来验证定期CECT的有效性。