Optimizing microwave ablation techniques for targeted cancer therapy

优化微波消融技术以进行癌症靶向治疗

• 批准号: 8206684
• 负责人: Christopher L Brace
• 金额: $ 28.41万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8206684
• 关键词: Ablation; Adoption; Affect; Algorithms; Area; Blood flow; Body part; Cancerous; Clinic; Clinical; Clinical Trials; Cryosurgery; Data; Development; Devices; Electric Conductivity; Engineering; Equipment; Frequencies; Growth; Heating; Histocompatibility Testing; Human; Hybrids; Image; Knowledge; Lasers; Liver; Lung; Medical; Medicine; Modality; Modeling; Monitor; Operative Surgical Procedures; Patient Care; Patients; Performance; Phase; Physiologic pulse; Plague; Preclinical Testing; Procedures; Property; Puncture procedure; Radiofrequency Interstitial Ablation; Recurrence; Reporting; Role; Source; Specificity; Speed; System; Techniques; Technology; Thermal Ablation Therapy; Time; Tissue Model; Tissues; Translations; Treatment Efficacy; Treatment Protocols; base; bone; cancer care; cancer therapy; clinical efficacy; clinical practice; clinically relevant; cryogenics; design; experience; improved; industry partner; innovation; interstitial; killings; microwave electromagnetic radiation; minimally invasive; oncology; patient population; public health relevance; radiofrequency; simulation; stem; therapy design; tool; tumor

DESCRIPTION (provided by applicant): The long-term objective of this project is to improve devices and techniques for microwave tumor ablation and extend its application into new patient populations by optimizing system design and energy delivery in several tissue types. Microwave ablation is superior to currently available technologies in many respects: microwaves provide rapid volumetric heating, leading to more precise and complete treatments; microwave heating is less dependent on tissue properties, making it more suitable for emerging targets (e.g., lung and bone); and using multiple antennas improves treatment control, precision and efficacy. Unfortunately, current systems have failed to deliver on these promises and patients who could benefit from improved therapies have suffered. This proposal is based on the idea that understanding more about microwave tissue heating will facilitate development of optimized systems and techniques that will enhance patient benefit and expand the role of microwave ablation in cancer care. As microwave ablation systems begin to enter the marketplace, optimized treatment protocols will be required to enhance patient benefit and expand the role of microwave ablation in clinical cancer care. To this end, we propose to: 1) Create improved numerical models of tissue to more accurately predict device performance. Hypothesis: Accurate tissue models improve numerical simulations, easing design and treatment optimization. 2) Optimize antenna designs and power delivery for tissue-specific treatments Hypotheses: Antenna design and frequencies can be optimized for specific tissues or treatment targets. Applying high-power pulses will more rapidly coagulate tissue microvasculature to improve efficacy. When combined, these optimizations will create ablations 50% faster and 25% larger than current systems. 3) Develop multiple-antenna application techniques to optimize treatment speed and specificity. Hypotheses: Multiple-antenna techniques improve efficacy and precision, allowing more tailored treatments without increasing invasiveness. Ablations can be created by 50% faster and 40% larger than current systems. 4) Facilitate real-time adaptive power control by using integrated treatment monitoring Hypothesis: Treatment monitoring can be accomplished without imaging, using only the interstitial applicator. If successful, this project will advance knowledge of microwave tissue heating, and create innovative and unique approaches to power delivery that utilize all of the advantages that microwaves offer. These aims will substantially change clinical practice by increasing the size of tumors that can be treated with microwaves, further broadening the scope of microwave ablation to areas outside the liver and increasing the number of patients benefiting from minimally invasive treatments. PUBLIC HEALTH RELEVANCE: This proposal will combine the best of engineering and medicine to better understand how ablations are created, develop tools for improved system design, and create a cancer treatment platform that requires minimal invasiveness to provide maximal patient benefit.

描述（由申请人提供）： 该项目的长期目标是通过优化几种组织类型的系统设计和能量输送来改善微波肿瘤消融的设备和技术，并将其应用于新的患者群体。在许多方面，微波消融优于当前可用的技术：微波提供快速的体积加热，从而提供了更精确和完整的处理；微波加热较少依赖组织特性，使其更适合新兴靶标（例如肺和骨骼）；并使用多个天线改善治疗控制，精度和功效。不幸的是，当前的系统未能兑现这些诺言，并且可以从改善疗法中受益的患者遭受了损失。 该提议基于这样的想法：对微波组织加热的更多了解将有助于开发优化的系统和技术，从而增强患者的利益并扩大微波消融在癌症护理中的作用。随着微波消融系统开始进入市场，将需要优化的治疗方案来增强患者的利益并扩大微波消融在临床癌症护理中的作用。为此，我们建议：1）创建改进的组织数值模型，以更准确地预测设备性能。假设：准确的组织模型改善了数值模拟，放松设计和治疗优化。 2）优化组织特异性处理的天线设计和动力传递假设：可以针对特定的组织或治疗靶标优化天线设计和频率。施加高功率脉冲将更快地凝结组织微脉管系统以提高功效。合并后，这些优化将使消融速度快50％，比当前系统大25％。 3）开发多个Antenna应用技术以优化治疗速度和特异性。假设：多 - 安特纳技术提高了功效和精度，从而允许更量身定制的治疗方法，而无需提高侵入性。消融可以比当前系统更快地创建50％，并且大40％。 4）通过使用集成治疗监测假设来促进实时自适应能力控制：只能使用间质施加器就可以完成治疗监测，而无需成像。 如果成功的话，该项目将提高微波组织加热的知识，并创建创新和独特的动力传递方法，以利用微波提供的所有优势。这些目标将通过增加可以用微波处理的肿瘤的大小来实质性改变临床实践，从而进一步扩大微波消融到肝脏外部地区的范围，并增加受益于微创治疗的患者数量。 公共卫生相关性： 该建议将结合工程和医学的最佳选择，以更好地了解如何创建消融，开发改进系统设计的工具，并创建一个癌症治疗平台，该平台需要最少的侵入性才能提供最大的患者利益。