HYBRID PRF-THERMOMETRY IN THE MYOCARDIUM

心肌中的混合 PRF 测温技术

• 批准号: 8362946
• 负责人: VIOLA RIEKE
• 金额: $ 1.95万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362946
• 关键词: Ablation; Annual Reports; Breathing; Cardiac; Diastole; Frequencies; Funding; Grant; Heating; Hybrids; Image; Intervention; Left; Left ventricular structure; Libraries; Magnetic Resonance; Measures; Methods; Modeling; Monitor; Myocardium; National Center for Research Resources; Phase; Principal Investigator; Procedures; Process; Protons; Reading; Research; Research Infrastructure; Resources; Slide; Source; Systole; Technology; Temperature; Thermometry; Time; Treatment outcome; Uncertainty; United States National Institutes of Health; Ventricular; Visit; abstracting; base; cost; image reconstruction; interest; reconstruction; time use; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: In recent years there has been increased interest to perform cardiac interventions such as EP ablation under MR-guidance. Directly monitoring the temperature rise during these procedures could potentially be helpful to verify successful ablation and predict treatment outcome. Here, we investigate the feasibility of monitoring temperature changes in the left ventricular myocardium in real-time. Temperature images based on the proton resonance frequency (PRF) shift are reconstructed using a hybrid method that combines multi-baseline subtraction and referenceless thermometry. Materials and Methods: Short-axis free-breathing cardiac images were acquired in three volunteers (no heat applied) in real-time using spiral gradient echo acquisitions with 4-5 interleaves on a 3T scanner using echo times of 3 ms, 5 ms, and 7 ms. Hybrid temperature image reconstruction was performed off-line in Matlab. The hybrid imaging model assumes that three sources contribute to image phase during thermal treatment: Background anatomical phase, spatially smooth phase deviations, and focal, heat-induced phase shifts. For the referenceless portion of the processing, sixth-order background polynomials were used and the multi-baseline libraries were comprised of 150 images (sliding window reconstruction) acquired during free breathing, representing approximately three cardiac cycles. Temperature reconstruction was performed over circular regions of interest containing the entire left ventricle. Temperature uncertainty was measured in the septum and the free ventricular wall in images during systole and diastole. To read about other projects ongoing at the Lucas Center, please visit http://rsl.stanford.edu/ (Lucas Annual Report and ISMRM 2011 Abstracts)

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 目的：近年来，执行心脏干预（例如EP消融）的兴趣增加 先生施用。在这些过程中直接监测温度升高可能有助于验证 成功消融并预测治疗结果。在这里，我们研究了监测温度变化的可行性 实时在左心室心肌中。基于质子共振频率（PRF）偏移的温度图像 使用混合方法重建，该混合方法结合了多基线减法和无引用的热度法。 材料和方法：在三名志愿者中获取短轴自由呼吸心脏图像（无热量） 使用螺旋梯度回声采集实时使用4-5个交通工具在3T扫描仪上使用3 ms，5 ms的回波时间和 7 ms。 在MATLAB中进行离线进行杂交温度图像重建。混合成像模型假设三个 来源在热处理期间有助于图像阶段：背景解剖阶段，空间平滑阶段 偏差和局灶性热诱导的相移。 对于处理的无参考部分，使用了六阶背景多项式和多基线 图书馆由在自由呼吸过程中获取的150张图像（滑动窗口重建）组成，代表 大约三个心脏周期。温度重建是在含有的圆形区域进行的。 整个左心室。温度不确定性在隔膜中测量和图像中的自由心室壁 在收缩和舒张期间。 要了解卢卡斯中心正在进行的其他项目，请访问http://rsl.stanford.edu/（卢卡斯年度报告和 ISMRM 2011摘要）