CSHL 2014 Glia Health & Disease Conference

CSHL 2014 神经胶质健康

• 批准号: 8790273
• 负责人: DAVID J. STEWART
• 金额: $ 1万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8790273
• 关键词: Action Potentials; Advanced Development; Amyotrophic Lateral Sclerosis; Area; Axon; Behavior; Biochemistry; Biological Models; Biology; Brain; Cell physiology; Cells; Cicatrix; Data; Development; Disease; Energy-Generating Resources; Ensure; Environment; Equilibrium; Event; Exposure to; Faculty; Fostering; Functional disorder; Future; Gene Mutation; Genetic; Goals; Health; Huntington Disease; Image; Injury; International; Invertebrates; Ions; Laboratories; Lead; Length of Stay; Link; Metabolic; Methodology; Minority; Molecular; Molecular Biology; Molecular Genetics; Mutation; Natural regeneration; Nerve Regeneration; Nervous System Physiology; Nervous system structure; Neurodegenerative Disorders; Neuroglia; Neuromodulator; Neurons; Neurotransmitter Receptor; Neurotransmitters; Oral; Participant; Physiology; Play; Postdoctoral Fellow; Published Comment; Research; Research Institute; Research Personnel; Resolution; Resource Development; Role; Schedule; Scientist; Series; Structure; Synaptic plasticity; Trauma; Woman; Work; abstracting; base; cost; extracellular; genetic manipulation; graduate student; human disease; in vivo imaging; interest; laboratory facility; meetings; member; nervous system development; nervous system disorder; neural circuit; new therapeutic target; notch protein; novel strategies; novel therapeutic intervention; novel therapeutics; posters; relating to nervous system; repaired; success; symposium; therapeutic development; tool; transmission process; unpublished works

The proposed meeting on Glia in Health & Disease will be held at Cold Spring Harbor Laboratory July 17 ¿ 21, 2014. The goal of this conference is to provide an active forum for exchange of results in the rapidly advancing fields of glial biology and neuron-glia interactions. Glial cells comprise a diverse group of non-neuronal cells that are essential for nervous system development, circuit function, and neurological disease. These cells perform many supportive roles, such as controlling extracellular ion and neurotransmitter levels, providing neurons with a source of energy, and ensheathing axons to enable rapid transmission of action potentials with minimal metabolic cost. The development of advanced genetic tools is beginning to define the molecular events that establish and maintain these crucial interactions, providing new targets for therapeutic manipulation. In addition, recent studies suggest that glial cells can play a much more active role in modulating the function of neural circuits; glial cells express receptors for neurotransmitters and can release neuroactive compounds that influence neural firing and synaptic plasticity. Nevertheless, the conditions required to activate different types of glial cells and induce the release of neuromodulators are not well understood. Glia also help the CNS recover from injury and disease, by forming glial scars, by engulfing dying neurons and debris, and by regenerating lost cells. However, glia also undergo reactive changes that can compromise their ability to adequately support neurons. The mechanisms that control these changes and the consequences of their altered behavior in disease and injury are just beginning to be defined. It has become clear that many gene mutations linked to neurodegenerative diseases, such as Huntington¿s Disease and amyotrophic lateral sclerosis (ALS), are also expressed in glia, and genetic manipulation studies are beginning to reveal how these mutations alter glial cell function and contribute to disease. This meeting will highlight the latest developments obtained through studies of both invertebrate and vertebrate model systems, and provide exposure to technological advances in genetics, molecular biology, biochemistry, physiology, and high resolution imaging. Using the goals and format of the four prior extremely successful meetings as a guide, we plan to 1) assemble an international meeting of scientists engaged in studies of glial biology and neuron-glia interactions; 2) discuss new and exciting developments in the field by selecting talks from openly submitted abstracts on the basis of scientific merit; 3) provide an opportunity for junior scientists of diverse backgrounds to present their data and engage in scientific discourse with more established investigators; and 4) promote collaborative interactions to accelerate the pace of discovery and identify novel approaches to treat diseases of the nervous system.

拟议的神经胶质细胞健康与疾病会议将在冷泉港举行 实验室 7 月 17 日 ¿ 2014 年 2 月 21 日。本次会议的目标是为 交流快速发展的神经胶质生物学和神经元-神经胶质相互作用领域的成果。 神经胶质细胞由一组不同的非神经元细胞组成，对神经系统至关重要 这些细胞在发育、回路功能和神经系统疾病方面发挥着许多支持作用。 作用，例如控制细胞外离子和神经递质水平，为神经元提供 能量来源，并包裹轴突以实现动作电位的快速传输 先进遗传工具的开发开始定义最小的代谢成本。 建立并维持这些关键相互作用的分子事件，为 此外，最近的研究表明神经胶质细胞可以发挥很大的作用。 在调节神经回路功能中发挥更积极的作用；神经胶质细胞表达受体 神经递质并可以释放影响神经放电的神经活性化合物 然而，激活不同类型的神经胶质细胞所需的条件。 并诱导神经调节剂的释放还不清楚。神经胶质细胞也有助于中枢神经系统。 通过形成神经胶质疤痕、吞噬垂死的神经元和碎片，从损伤和疾病中恢复， 然而，神经胶质细胞也会发生反应性变化。 损害它们充分支持神经元的能力。 他们的疾病和伤害行为的变化及其后果才刚刚开始 很明显，许多基因突变与神经退行性疾病有关。 疾病，例如亨廷顿病?? s 疾病和肌萎缩侧索硬化症 (ALS) 也属于 在神经胶质细胞中表达，基因操作研究开始揭示这些突变是如何发生的 改变神经胶质细胞功能并导致疾病。本次会议将重点介绍最新的研究成果。 通过对无脊椎动物和脊椎动物模型系统的研究获得的进展，以及 提供遗传学、分子生物学、生物化学等领域的技术进步， 生理学和高分辨率成像使用前四个极其的目标和格式。 以成功的会议为指导，我们计划 1) 组织一次国际科学家会议 从事神经胶质生物学和神经元-神经胶质相互作用的研究；2) 讨论新的和令人兴奋的内容； 通过从公开提交的摘要中选择演讲来了解该领域的发展 科学价值；3）为不同背景的年轻科学家提供展示的机会 他们的数据并与更成熟的研究人员进行科学讨论；4) 促进协作互动，以加快发现和识别新颖的步伐 治疗神经系统疾病的方法。