Gastric Histopathology Core

胃组织病理学核心

• 批准号: 8413060
• 负责人: MARY Kay WASHINGTON
• 金额: $ 18.54万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8413060
• 关键词: Attention; Collaborations; Disease; Ensure; Evaluation; Funding; Gastric Tissue; Gastritis; Grant; Health Services Accessibility; Helicobacter; Helicobacter pylori; Histologic; Histology; Histopathology; Human; Immunohistochemistry; Inflammation; Lasers; Microdissection; Mission; Neoplasms; Operative Surgical Procedures; Pathologist; Pathology; Persons; Process; Proteomics; Quality Control; Research; Research Personnel; Resources; Rodent Model; Services; Slide; Staining method; Stains; Stomach; Supervision; Tissue Microarray; Tissue Sample; Tissues; Washington; Work; animal tissue; carcinogenesis; gastrointestinal; high risk; high standard; human disease; human tissue; interest; malignant stomach neoplasm; programs; quality assurance

The primary mission of the Gastric Histopathology Core is to provide high quality, rapid-turnaround histology and immunohistochemistry services to investigators in this PPG, and to provide expert histopathologic nterpretation, through collaboration with Dr. Kay Washington. The following services are proposed: 1. To provide high quality, rapid-turnaround research histology services to PPG investigators. 2. To provide expert evaluation of histopathology of rodent models of H. pylori-Induced gastric neoplasia and correlation with human disease. 3. To provide expertise in developing, performing and evaluating immunohistochemical studies on animal tissues. 4. To provide laser microdissection services. 5. To perform quality control to ensure that histology and immunohistochemistry services are of highest quality. 6. To provide tissue microarray services and access to human gastric tissue samples as needed. The three component projects and Core B (Proteomics Core) of this proposed Program Project all rely heavily upon morphologic analysis of gastric tissues isolated from rodent models of Helicobacter pyloriinduced gastritis and gastric neoplasia. Dr. Washington's expertise in interpretation of histopathologic changes in rodent models and in interpretation of immunohistochemical studies will be critical to this work, and this collaborative activity is currently not funded through existing resources. By utilizing the resources of an established Research Histology facility for tissue storage, processing, cutting of blocks, and staining of slides, it will be possible to achieve high standards for all histologic studies proposed in this grant. This centralization of histologic services under the supervision of a surgical pathologist with a dedicated interest in gastrointestinal pathology will allow careful attention to quality assurance.

胃组织病理学核心的主要任务是提供高质量、快速周转的组织学 和免疫组织化学服务为本 PPG 的研究人员提供专家组织病理学服务 通过与凯华盛顿博士合作进行解释。建议提供以下服务： 1. 为 PPG 研究人员提供高质量、快速周转的研究组织学服务。 2. 为H. pylori诱发的胃肿瘤啮齿动物模型的组织病理学提供专家评估 以及与人类疾病的相关性。 3. 提供开发、执行和评估动物免疫组织化学研究的专业知识 组织。 4.提供激光显微切割服务。 5. 进行质量控制，确保组织学和免疫组化服务达到最高水平 质量。 6. 根据需要提供组织微阵列服务并获取人体胃组织样本。 本拟议计划项目的三个组成项目和核心 B（蛋白质组学核心）均依赖于 很大程度上依赖于从幽门螺杆菌诱导的啮齿动物模型中分离出的胃组织的形态学分析 胃炎和胃肿瘤。华盛顿博士在解释组织病理学方面的专业知识 啮齿动物模型的变化和免疫组织化学研究的解释对于这项工作至关重要， 目前，这项合作活动并未通过现有资源提供资金。通过利用资源 一个成熟的组织学研究设施，用于组织储存、处理、块切割和染色 幻灯片，将有可能实现这笔拨款中提出的所有组织学研究的高标准。这 在专门关注以下问题的外科病理学家的监督下集中组织学服务 胃肠道病理学将允许仔细注意质量保证。