Tennessee Valley Cooperative Human Tissue Network

田纳西谷合作人体组织网络

基本信息

批准号：
9247707
负责人：
MARY Kay WASHINGTON
金额：
$ 98.9万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-01 至 2019-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9247707
关键词：
Advocate Awareness Basic Science Biomedical Research Businesses Clinical Collection Communication Communities Complex Computer software Confidentiality of Patient Information Cooperative Human Tissue Network DNA Data Set Development Disease Education Funding Generations Goals Healthcare Human Informatics Informed Consent Link Malignant Neoplasms Marketing Modeling Modernization Patients Play Procedures Process Public Health Quality Control RNA Rare Lesion Recording of previous events Research Research Personnel Resources Role Services Solid Source Specimen System Tennessee Tissue Microarray Tissue Sample Tissues Translational Research biobank cost effective experience human disease human tissue improved individual patient innovation member neoplastic operation programs prospective public health relevance tumor tumor progression web services

项目摘要

DESCRIPTION (provided by applicant): The Cooperative Human Tissue Network (CHTN) has played an important role since 1987 as a source of human tissues to support biomedical research. As the Western Division of the CHTN, we propose to continue to serve the scientific community by procuring and distributing biospecimens in an efficient, cost-effective manner. The specific aims of this application are: 1) To collect, process and distribute high quality human solid tissue and biofluid specimens with appropriate clinical annotation to qualified researchers on a prospective basis; 2) To apply a rigorous Quality Management System to all aspects of the program; 3) To provide tumor macrodissection, tissue microarray "build on demand" and RNA/DNA extraction services, as requested; 4) To collect and bank pre-neoplastic and rare lesions to facilitate basic research in tumor progression and early translational research; 5) To protect patient confidentiality by obtaining informed consent for collection of extraneous tissue and biofluids for research, and through de-identification of specimens, and by continuing to partner with VUMC patient advocates to engage patients and provide opportunities for participation in research; 6) To develop and integrate new business models and informatics (IT) strategies that improve operational efficiency, by developing a third generation network Investigator IT system for request sharing; 7) To develop innovative internal IT programs by partnering with VUMC BioVu project to link tissue samples to large clinical datasets, and by providing an internal mechanism for research results sharing at VUMC as a pilot program; 8) To expand CHTN marketing and education efforts through strategies to increase awareness in the scientific community. In 12 years as a CHTN Division, we have been an innovative and highly productive member of the network, distributing over 63,170 specimens to 723 investigators in the last 5 years. We have developed critical SOPs and integrative biorepository software that have been implemented throughout the CHTN. Our goals in the next funding period include continuing to provide numerous high quality biospecimens and to develop innovative IT programs to improve efficiency and communication within the network and with investigators.

描述（由申请人提供）：自 1987 年以来，人体组织合作网络 (CHTN) 作为支持生物医学研究的人体组织来源发挥了重要作用。作为 CHTN 的西部部门，我们建议继续以高效、具有成本效益的方式采购和分发生物样本，为科学界服务。该应用程序的具体目标是： 1）收集、处理和分发高质量的人力资源前瞻性地向合格的研究人员提供具有适当临床注释的实体组织和生物流体样本； 2) 将严格的质量管理体系应用于项目的各个方面； 3) 根据要求提供肿瘤宏观解剖、组织微阵列“按需构建”和RNA/DNA提取服务； 4）收集并储存肿瘤前和罕见病灶，以促进肿瘤进展的基础研究和早期转化研究； 5) 通过获取收集外来组织和生物体液用于研究的知情同意、标本的去识别化以及继续与 VUMC 患者倡导者合作，吸引患者参与并提供参与研究的机会，保护患者的机密性； 6) 通过开发用于请求共享的第三代网络调查员 IT 系统，开发和整合新的业务模式和信息学 (IT) 战略，以提高运营效率； 7) 与 VUMC BioVu 项目合作，开发创新的内部 IT 项目，将组织样本与大型临床数据集联系起来，并提供 VUMC 研究成果共享的内部机制作为试点项目； 8) 通过提高科学界认识的策略，扩大 CHTN 的营销和教育工作。作为 CHTN 部门的 12 年来，我们一直是该网络中创新且高效的成员，在过去 5 年中向 723 名研究人员分发了超过 63,170 个样本。我们开发了关键的 SOP 和综合生物样本库软件，并已在整个 CHTN 中实施。我们在下一个资助期的目标包括继续提供大量高质量的生物样本，并开发创新的 IT 项目，以提高网络内以及与研究人员的效率和沟通。