Gastric Histopathology Core

胃组织病理学核心

• 批准号: 8632354
• 负责人: MARY Kay WASHINGTON
• 金额: $ 17.4万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8632354
• 关键词: Animal Model; Attention; Award; Cancer Center; Collaborations; Cooperative Human Tissue Network; Digestive System Disorders; Equipment; Evaluation; Fee-for-Service Plans; Funding; Gastric Tissue; Gastritis; Gastrointestinal Diseases; Grant; Health Services Accessibility; Helicobacter pylori; Histologic; Histology; Histopathology; Housing; Human; Human Resources; Immunohistochemistry; Inflammation; Laboratories; Lasers; Malignant neoplasm of gastrointestinal tract; Measures; Medical center; Microdissection; Mission; Morphology; Neoplasms; Operative Surgical Procedures; Pathologist; Pathology; Persons; Play; Proteomics; Quality Control; Research; Research Personnel; Resource Sharing; Resources; Rodent Model; Role; Services; Specimen; Stomach; Structure; Supervision; Time; Tissue Microarray; Tissue Sample; Tissues; United States National Institutes of Health; Washington; Work; animal tissue; anticancer research; base; carcinogenesis; experience; gastrointestinal; high risk; high standard; human disease; human tissue; interest; laser capture microdissection; malignant stomach neoplasm; programs; quality assurance; tissue resource

The primary mission of the Gastric Histopathology Core is to provide high quality, rapid-turnaround immunohistochemistry and specialized research histology services to investigators in this PPG, and to provide expert histopathologic interpretation, through collaboration with Dr. Kay Washington and Dr. M. Blanca Piazuelo. The following services are proposed: 1. To provide expert evaluation of histopathology of rodent models of H. pylori-induced gastric neoplasia and correlation with human disease 2. To provide expertise in developing, performing and evaluating immunohistochemical studies on animal tissues, with robust quality control measures, and with extension to human tissue if needed 3. To provide laser microdissection services 4. To provide tissue microarray services and access to human gastric tissue samples as needed The three component projects and Core B (Proteomics Core) of this proposed Program Project all rely heavily upon morphologic analysis of gastric tissues isolated from rodent models of Helicobacter pylori-induced gastritis and gastric neoplasia. Dr. Washington's and Dr. Piazuelo's expertise in interpretation of histopathologic changes in rodent models and in interpretation of immunohistochemical studies will be critical to this work, and these collaborative activities are currently not funded through existing resources. By utilizing the resources of an Gl research-related immunohistochemistry facility, it will be possible to achieve high standards for all histologic studies proposed in this grant. This centralization of histologic services under the supervision of experienced pathologists with a dedicated interest in gastrointestinal pathology will allow careful attention to quality assurance.

胃组织病理学核心的主要任务是提供高质量的快速发展 通过与Kay Washington博士和M. Blanca Piazuelo博士的合作，为该PPG的研究人员提供免疫组织化学和专业研究组织学服务，并提供专家组织病理学解释。提出了以下服务： 1。提供专家评估幽门螺杆菌诱导的胃肿瘤的啮齿动物模型的组织病理学以及与人类疾病的相关性 2。提供有关开发，执行和评估免疫组织化学研究的专业知识 动物组织，采用强大的质量控制措施，并在需要时扩展到人体组织 3。提供激光显微解剖服务 4。提供组织微阵列服务并根据需要提供人类胃组织样品 该提出的计划项目的三个组件项目和核心B（蛋白质组学核心）都在很大程度上依赖于从幽门螺杆菌诱导的胃炎和胃肿瘤的啮齿动物模型中分离出的胃组织的形态分析。华盛顿博士和Piazuelo博士在解释啮齿动物模型中的组织病理学变化方面的专业知识以及对免疫组织化学研究的解释对这项工作至关重要，并且这些协作活动目前不是通过现有资源来资助的。通过利用与GL研究相关的免疫组织化学设施的资源，可以在本赠款中提出的所有组织学研究中获得高标准。在经验丰富的病理学家的监督下，对组织学服务的集中化对胃肠道病理非常感兴趣，将允许仔细注意质量保证。