Tennessee Valley Cooperative Human Tissue Network

田纳西谷合作人体组织网络

• 批准号: 9899210
• 负责人: MARY Kay WASHINGTON
• 金额: $ 91.28万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9899210
• 关键词: Academic Medical Centers; Achievement; Adherence; Adult; Advocacy; Awareness; Basic Science; Biological; Biomedical Research; Businesses; Cells; Clinical; Collection; Communication; Communities; Complex; Computer software; Confidentiality of Patient Information; Cooperative Human Tissue Network; Custom; Data Set; Development; Disease; Education; Ensure; Ethics; Feedback; Foundations; Funding; Goals; Healthcare; Human; Industry Standard; Informatics; Infrastructure; International; Leadership; Link; Malignant Neoplasms; Marketing; Modeling; Modernization; Patients; Performance; Play; Population; Process; Public Health; Quality Control; Rare Lesion; Regulation; Research; Research Personnel; Role; Security; Services; Ships; Site; Societies; Solid; Source; Specimen; Suspensions; System; Tennessee; Thinness; Tissue Sample; Tissues; Translational Research; Tumor-Infiltrating Lymphocytes; biobank; cost effective; design; experience; human disease; human subject protection; human tissue; improved; individual patient; innovation; member; neoplastic; network informatics; novel; operation; programs; prospective; repository; response; satisfaction; science education; social media; tumor progression; web services

PROJECT SUMMARY The Cooperative Human Tissue Network (CHTN) has played an important role since 1987 as a source for human tissues for biomedical research. To this end, the overarching goal of the Western Division of the CHTN at Vanderbilt University Medical Center (CHTN-VUMC) is to continue to serve the scientific community by procuring and distributing adult biospecimens, utilizing a stringent quality management program to maintain a highly efficient and productive biorepository operation. Key aspects of this goal are the prospective customized collection of high quality solid tissues and biofluids with clinical annotation and application of a rigorous Quality Management System to all aspects of the program. Demographic coverage will be expanded by launching two additional satellite sites for collection. New services, such as single-cell suspensions, isolation of tumor infiltrating lymphocytes and TMA Build On Demand in response to changing investigator needs are proposed. In addition preneoplastic and rare lesions will be banked to facilitate research in tumor progression. The CHTN-VUMC will adhere to rigorous ethical standards for protection of human subjects and patient confidentiality, and will partner with the VUMC advocacy program to engage patients and provide opportunities for participation in research. We also propose to serve as the Informatics (IT) trans-network Coordinating Center responsible for the second version of the “Investigators IT” system, utilizing web services and a strong modern technologically advanced platform and ensuring adherence to IT security best practices. In its divisional IT strategy, CHTN-VUMC will develop and integrate new business models and novel informatics strategies to improve operational efficiency, including partnering with the VUMC BioVu project to link tissue samples to large clinical datasets. Marketing efforts will include initiatives to increase awareness of CHTN in the scientific community, including enhanced use of social media, and CHTN-VUMC will actively contribute to biorepository science and education through leadership in societies such as the International Society for Biological and Environmental Repositories. CHTN-VUMC's leadership in network IT development makes the division uniquely qualified to serve as the central IT site. A robust track record of specimen distribution, with 64,358 specimens shipped to 1011 investigators over the past 6.5 years, highlights the capabilities of the existing CHTN-VUMC infrastructure. CHTN-VUMC goals in the next funding period include building upon these foundational achievements to improve efficiency and communication within the network, investigators and scientific community.

项目摘要 自1987年以来，合作的人体组织网络（CHTN）作为来源发挥了重要作用 用于生物医学研究的人体组织。 范德比尔特大学医学中心（CHTN-VUMC）的CHTN将包含以服务于科学的 通过采购和分发成人生物测量，利用严格的质量管理，社区 维持高效和生产性生物座席的计划。 是与临床的高质量固体固体tithluids的望远镜集合 严格质量管理的注释和应用。 通过推出新的卫星站点，将扩大人口覆盖范围 诸如单细胞悬浮液，肿瘤浸润淋巴细胞的隔离和TMA的隔离 响应不断变化的研究者需求的需求是支撑的。 病变将促进肿瘤进展。 严格保护人类受试者和患者信心的严格道德标准，并将合作 随着VUMC倡导计划，可以吸引患者并提供任何机会 研究。 负责第二版的“研究人员IT”系统，利用Web服务和强大的 现代技术高级平台，并确保IT安全性最佳实践 CHTN-VUMC部门IT策略将开发和整合新的商业模式和新颖 提高运营效率的信息学策略，包括与VUMC BIOVU合作 将组织样本与大型临床数据集联系起来的项目。 提高科学界对CHTN的认识，包括增强社交媒体的使用，以及 CHTN-VUMC将通过领导才能激活生物问题科学和教育 国际生物与环境储藏库社会等社会。 CHTN-VUMC在网络中的领导IT开发领导 中央IT站点。 1011调查人员在过去的6.5 Youars中，突出了现有CHTN-VUMC的能力 基础架构。 取得的成就，以提高网络，调查人员和科学的效率和沟通 社区。