Gastric Histopathology Core

胃组织病理学核心

• 批准号: 8990359
• 负责人: MARY Kay WASHINGTON
• 金额: $ 4.82万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-01-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8990359
• 关键词: Animal Model; Attention; Award; Cancer Center; Collaborations; Cooperative Human Tissue Network; Digestive System Disorders; Equipment; Evaluation; Fee-for-Service Plans; Funding; Gastric Tissue; Gastritis; Gastrointestinal Diseases; Grant; Health Services Accessibility; Helicobacter pylori; Histologic; Histology; Histopathology; Housing; Human; Human Resources; Immunohistochemistry; Inflammation; Laboratories; Lasers; Malignant neoplasm of gastrointestinal tract; Measures; Medical center; Microdissection; Mission; Morphology; Neoplasms; Operative Surgical Procedures; Pathologist; Pathology; Persons; Play; Proteomics; Quality Control; Research; Research Personnel; Resource Sharing; Resources; Rodent Model; Role; Services; Specimen; Stomach; Structure; Supervision; Time; Tissue Microarray; Tissue Sample; Tissues; United States National Institutes of Health; Washington; Work; animal tissue; anticancer research; base; carcinogenesis; experience; gastrointestinal; high risk; high standard; histological studies; human disease; human tissue; interest; laser capture microdissection; malignant stomach neoplasm; programs; quality assurance; tissue resource

The primary mission of the Gastric Histopathology Core is to provide high quality, rapid-turnaround immunohistochemistry and specialized research histology services to investigators in this PPG, and to provide expert histopathologic interpretation, through collaboration with Dr. Kay Washington and Dr. M. Blanca Piazuelo. The following services are proposed: 1. To provide expert evaluation of histopathology of rodent models of H. pylori-induced gastric neoplasia and correlation with human disease 2. To provide expertise in developing, performing and evaluating immunohistochemical studies on animal tissues, with robust quality control measures, and with extension to human tissue if needed 3. To provide laser microdissection services 4. To provide tissue microarray services and access to human gastric tissue samples as needed The three component projects and Core B (Proteomics Core) of this proposed Program Project all rely heavily upon morphologic analysis of gastric tissues isolated from rodent models of Helicobacter pylori-induced gastritis and gastric neoplasia. Dr. Washington's and Dr. Piazuelo's expertise in interpretation of histopathologic changes in rodent models and in interpretation of immunohistochemical studies will be critical to this work, and these collaborative activities are currently not funded through existing resources. By utilizing the resources of an Gl research-related immunohistochemistry facility, it will be possible to achieve high standards for all histologic studies proposed in this grant. This centralization of histologic services under the supervision of experienced pathologists with a dedicated interest in gastrointestinal pathology will allow careful attention to quality assurance.

胃组织病理学核心的首要任务是提供高质量、快速周转的服务 通过与 Kay Washington 博士和 M. Blanca Piazuelo 博士合作，为该 PPG 的研究人员提供免疫组织化学和专门研究组织学服务，并提供专家组织病理学解释。建议提供以下服务： 1. 对幽门螺杆菌引起的胃肿瘤啮齿动物模型的组织病理学及其与人类疾病的相关性提供专家评估 2. 提供开发、执行和评估免疫组织化学研究的专业知识 动物组织，具有严格的质量控制措施，并在需要时扩展到人体组织 3. 提供激光显微切割服务 4. 根据需要提供组织芯片服务并获取人体胃组织样本 该计划项目的三个组成项目和核心 B（蛋白质组学核心）都严重依赖于从幽门螺杆菌诱发的胃炎和胃肿瘤啮齿动物模型中分离出的胃组织的形态学分析。 Washington 博士和 Piazuelo 博士在解释啮齿动物模型的组织病理学变化和解释免疫组织化学研究方面的专业知识对这项工作至关重要，而这些合作活动目前尚未通过现有资源资助。通过利用与 GI 研究相关的免疫组织化学设施的资源，将有可能实现本次资助中提出的所有组织学研究的高标准。在对胃肠道病理学有专门兴趣的经验丰富的病理学家的监督下，组织学服务的集中化将使我们能够认真关注质量保证。