Dietary Patterns / Dietary Quality and Risk of RA in Women

女性饮食模式/饮食质量和 RA 风险

• 批准号: 8531860
• 负责人: Bing Lu
• 金额: $ 39.82万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-17 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8531860
• 关键词: Accounting; Address; Adult; Affect; All-Trans-Retinol; Alleles; Antioxidants; Arthritis; Autoimmune Diseases; Biochemical; Carotene; Cereals; Chronic; Cluster Analysis; Coffee; Cohort Studies; Consumption; Data; Development; Diet; Dietary Practices; Disease; Eating; Environment; Environmental Epidemiology; Environmental Risk Factor; Epidemiologic Studies; Etiology; Exogenous Hormone Therapy; Factor Analysis; Fatty acid glycerol esters; Female; Fishes; Food; Frequencies; Genes; Genetic; Goals; Individual; Intake; Interleukin-6; Investigation; Lutein; Measurement; Meat; Mediterranean Diet; Modification; Nurses; Nurses' Health Study; Nutrient; Olive oil preparation; Pathway interactions; Plasma; Population; Predisposition; Prevalence; Prevention; Prospective Studies; Public Health; Publishing; Questionnaires; Recommendation; Reproductive History; Rheumatism; Rheumatoid Arthritis; Rheumatoid Factor; Risk; Risk Factors; Sample Size; Serological; Statistical Models; TNFR-Fc fusion protein; Time; Tocopherols; United States; Vegetables; Vitamin D; Woman; base; case control; cigarette smoking; cohort; cooking; cost; cryptoxanthin; cyclic citrullinated peptide; design; disorder risk; epidemiology study; follow-up; food consumption; genetic epidemiology; genetic risk factor; good diet; indexing; inflammatory marker; lycopene; men; novel; novel strategies; nutritional epidemiology; prospective; protective effect; public health relevance; zeaxanthin

DESCRIPTION (provided by applicant): The etiology of rheumatoid arthritis (RA), remains incompletely understood. It is considered to be a multifactorial disease, resulting from the interaction of both genetic and environmental factors. Epidemiologic research has produced convincing data for associations between environmental risk factors, including cigarette smoking, exogenous hormone use and female reproductive factors and RA susceptibility. Dietary studies suggest that high intake of certain antioxidants, fish, olive oil and cooked vegetables confer a protective effect against the development of RA, whereas red meat, fat, dairy and cereals may increase the risk of RA, although evidence for dietary etiology is inconclusive. However, the effect of individual food groups and nutrients may be too small to detect with limited sample sizes in previous studies. Overall dietary pattern and dietary quality analysis examines the cumulative effects of multiple nutrients, and may thus be more predictive of disease risk than individual foods or nutrients. To date, no studies have assessed the association between overall dietary patterns / dietary quality and RA risk, especially in the setting of a well-controlled large prospective cohort study. The goal of the proposed investigation is to address whether overall dietary patterns / dietary quality are associated with risk of RA in women using data from the largest rheumatic disease environmental epidemiology study in the world, the two Nurses' Health Study Cohorts (NHS I and NHS II). We will also examine the causal pathways between dietary patterns / dietary quality, biochemical measurements including plasma antioxidants and markers of inflammation, and risk of developing RA in a matched case-control subsample nested in NHS I and II cohorts. In addition, we will investigate possible interactions between dietary patterns / dietary quality and genetic factors in RA susceptibility. With recent advances in genetic epidemiology and high throughput genotying, the study of gene-diet interactions has become an exciting direction in the field of nutritional epidemiology. Overall, the large size of these cohorts, the prospective design, the repeated and detailed measurements of diet and covariates, the high follow-up rates, and the availability of biochemical measurements provide a unique opportunity to study the relationship between overall dietary patterns /dietary quality and risk of RA in an extremely cost-efficient manner. We believe that this project presents a novel approach to study diet-RA relationships and will have important public health implications.

描述（由申请人提供）：类风湿关节炎（RA）的病因尚不完全理解。由于遗传和环境因素的相互作用，它被认为是一种多因素疾病。流行病学研究已经为环境风险因素（包括吸烟，外源激素使用和女性生殖因素和RA易感性）提供了令人信服的数据。饮食研究表明，对某些抗氧化剂，鱼类，橄榄油和煮熟的蔬菜的高摄入赋予了针对RA发展的保护作用，而红肉，脂肪，乳制品和谷物可能会增加RA的风险，尽管饮食病因的证据尚无定论。但是，在先前的研究中，单个食品群和营养物质的影响可能太小而无法检测到样本量有限。总体饮食模式和饮食质量分析研究了多种营养素的累积作用，因此可能比单个食品或营养更能预测疾病的风险。迄今为止，尚无研究评估整体饮食模式 /饮食质量和RA风险之间的关联，尤其是在一项良好控制的大型前瞻性队列研究的情况下。拟议的调查的目的是解决使用来自世界上最大的风湿病环境流行病学研究的数据（NHS I和NHS II）的总体饮食模式 /饮食质量是否与女性的RA风险有关。我们还将检查饮食模式 /饮食质量，生化测量值（包括血浆抗氧化剂和炎症标志物）之间的因果途径，以及在NHS I和II同类中嵌套的匹配病例对照的子样本中发展RA的风险。此外，我们将研究RA易感性中饮食模式 /饮食质量和遗传因素之间的可能相互作用。随着遗传流行病学和高吞吐量基因的最新进展，对基因 - 基因相互作用的研究已成为营养流行病学领域的一个令人兴奋的方向。总体而言，这些队列的较大尺寸，前瞻性设计，饮食和协变量的重复测量和详细的测量，高后续率以及生化测量的可用性为研究总体饮食模式 /饮食模式 /饮食质量和RA风险之间的关系提供了独特的机会。我们认为，该项目提出了一种研究饮食RA关系的新方法，并将具有重要的公共卫生影响。