Dietary Quality, Body Adiposity, and Risk of Rheumatoid Arthritis in Women

女性的饮食质量、身体肥胖和类风湿关节炎的风险

基本信息

批准号：
9893820
负责人：
Bing Lu
金额：
$ 48.01万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-05-01 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9893820
关键词：
Adherence Adipose tissue Adult Affect Age American Autoantibodies Autoimmune Benign Biological Biological Markers Body Weight Changes Body Weight decreased Body fat Body mass index Central obesity Chronic Chronic Disease Dairy Products Data Development Diagnosis Diet Diet Modification Dietary Factors Dietary Practices Disease Eating Energy Intake Energy Metabolism Environmental Exposure Etiology Fatty acid glycerol esters First Degree Relative Future Genetic Grain Healthy Eating Incidence Individual Inflammatory Intake Leptin Link Longitudinal Studies Matched Case-Control Study Measures Mediating Modeling Modification Nested Case-Control Study Nurses&apos Health Study Obesity Overweight Patients Pattern Play Population Prevention Principal Component Analysis Processed Meats Rare Diseases Reproductive History Rheumatoid Arthritis Risk Risk Factors Risk Reduction Role Smoking Structural Models Synovitis Time Waist-Hip Ratio Weight Gain Woman Work adipokines case control causal model cohort cost efficient dietary dietary guidelines high risk indexing middle age mortality novel nutritional epidemiology obesity development prevent prospective randomized trial resistin systemic inflammatory response tool trend waist circumference young adult

Adherence Adipose tissue Adult Affect Age American Autoantibodies Autoimmune Benign Biological Biological Markers Body Weight Changes Body Weight decreased Body fat Body mass index Central obesity Chronic Chronic Disease Dairy Products Data Development Diagnosis Diet Diet Modification Dietary Factors Dietary Practices Disease Eating Energy Intake Energy Metabolism Environmental Exposure Etiology Fatty acid glycerol esters First Degree Relative Future Genetic Grain Healthy Eating Incidence Individual Inflammatory Intake Leptin Link Longitudinal Studies Matched Case-Control Study Measures Mediating Modeling Modification Nested Case-Control Study Nurses&apos Health Study Obesity Overweight Patients Pattern Play Population Prevention Principal Component Analysis Processed Meats Rare Diseases Reproductive History Rheumatoid Arthritis Risk Risk Factors Risk Reduction Role Smoking Structural Models Synovitis Time Waist-Hip Ratio Weight Gain Woman Work adipokines case control causal model cohort cost efficient dietary dietary guidelines high risk indexing middle age mortality novel nutritional epidemiology obesity development prevent prospective randomized trial resistin systemic inflammatory response tool trend waist circumference young adult

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项目摘要

7. PROJECT SUMMARY / ABSTRACT Rheumatoid arthritis (RA) is the most common autoimmune inflammatory disease, characterized by persistent synovitis and systemic inflammation. RA is generally considered as a multifactorial disease, caused by both genetic factors and environmental exposures. Although some individual dietary factors have been identified to be associated with the development of RA, few studies have examined the effects of overall dietary quality and dietary patterns on RA risk. In our previous studies, we have demonstrated that adherence to the Dietary Guidelines for Americans or following a Prudent dietary pattern is associated with reduced RA risk, while a Western dietary pattern or a dietary inflammatory pattern, characterized by high intakes of red and processed meats, refined grains, desserts and sweets, and high-fat dairy products, increases RA risk in young and middle-aged women. However, little is known about whether modifying dietary quality influences subsequent RA risk. Often, it is not ethically or practically possible to conduct a perfectly randomized trial to study diet and risk of rare diseases, instead large longitudinal studies with repeated dietary measures can provide unique opportunities to evaluate the effect of diet changes on RA risk reduction using advanced causal inference models, which will have direct relevance for populations at highest risk such as first degree relatives of RA patients. Dietary factors directly and indirectly play an important role in the genesis of obesity. Individuals with obesity are at increased risk of major chronic diseases. We also identified obesity as a significant risk factor of RA, although the biologic mechanism is not yet understood. Further study is needed to evaluate the influences of weight gain or weight loss on the risk of RA using causal models. The adipokines produced by the adipose tissue, leading to a chronic inflammatory state, may play a central role in the development of obesity-related complications. In this application we propose to evaluate the modification of dietary quality as a potential strategy to prevent future development of RA using well-established causal inference models: Marginal Structural Models. This study also extends our earlier work to examine the influences of weight changes and body fat distribution on RA risk. We will also examine whether circulating adipokines associated with an increased risk of developing RA, and mediate the observed associations of dietary quality and obesity with RA risk in a matched case-control study nested in NHS and NHS II cohorts.

7。项目摘要 /摘要类风湿关节炎（RA）是最常见的自身免疫性炎症性疾病，其特征是持续滑膜炎和全身性炎症。 RA通常被认为是由两者都引起的多因素疾病遗传因素和环境暴露。尽管已经确定了一些个人饮食因素与RA的发展有关，很少有研究检查整体饮食质量和 RA风险的饮食模式。在我们先前的研究中，我们证明了对饮食的遵守美国人或遵循审慎饮食模式的指南与RA风险降低有关，而西方饮食模式或饮食炎症模式，其特征是红色的高摄入量肉类，精制谷物，甜点和糖果以及高脂乳制品，增加了年轻人和年轻人的风险中年妇女。但是，关于改变饮食质量的影响知之甚少随后的RA风险。通常，在道德上或实际上进行完全随机的试验是不可能的研究饮食和罕见疾病的风险，而是通过重复饮食措施进行大量纵向研究可以提供独特的机会来评估使用高级因果的饮食变化对降低RA风险的影响推理模型将与最高风险的人群（例如一级亲戚）具有直接相关性 RA患者。饮食因素直接和间接地在肥胖起源中起重要作用。有个人肥胖症患有主要慢性疾病的风险增加。我们还确定肥胖症是 RA，尽管尚未了解生物学机制。需要进一步的研究来评估影响使用因果模型在RA风险上体重增加或体重减轻。脂肪产生的脂肪因子导致慢性炎症状态的组织可能在与肥胖有关的发展中起核心作用并发症。在此应用中，我们建议评估饮食质量的修改，作为潜在的策略使用公认的因果推断模型来防止RA的未来开发：边际结构模型。这项研究还扩展了我们早期的工作以检查体重变化和体内脂肪分布的影响关于RA风险。我们还将检查循环脂肪因子是否与增加的风险有关在匹配的病例对照研究嵌套在NHS和NHS II队列中。