Metabolites of Dietary Intake and Risk of Knee Osteoarthritis

膳食摄入代谢物与膝骨关节炎的风险

基本信息

批准号：
10671254
负责人：
Bing Lu
金额：
$ 58.65万
依托单位：
UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-05 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10671254
关键词：
Ache Adherence Ancillary Study Arthritis Awareness Biological Biomarker of Dietary Intake Blood specimen Bone Marrow Cartilage Clinical Consumption Data Degenerative polyarthritis Development Diet Diet Records Dietary Assessment Dietary Factors Dietary Fiber Dietary Practices Dietary intake Disease Domestic Fowls Elderly Fabaceae Fasting Fatty acid glycerol esters Fishes Food Frequencies Future Genetic Grain Human Incidence Individual Inflammation Intake Intervention Studies Kellgren-Lawrence grade Knee Osteoarthritis Lesion Mass Fragmentography Measurement Measures Mediating Memory Metabolic Methods Milk Nested Case-Control Study Nutritional status Nutritive Value Obesity Outcome Pain Pathogenesis Patient Self-Report Pattern Play Prevention Prevention strategy Principal Component Analysis Processed Meats Prognostic Marker Proteins Public Health Questionnaires Reporting Risk Risk Factors Role Symptoms Technology Unsaturated Fats base cohort dietary disorder risk effusion epidemiology study fruits and vegetables good diet imaging biomarker magnetic resonance imaging biomarker metabolome metabolomics nutrient metabolism physically handicapped prognostic radiological imaging saturated fat willingness

项目摘要

PROJECT SUMMARY / ABSTRACT Osteoarthritis (OA) is the most common form of arthritis and the major cause of activity limitation and physical disability in older people. In the absence of disease modifying therapy, there is an urgent need for effective, widely available approaches to aid in the prevention and management of this common condition. Dietary factors associated with inflammation, obesity and other metabolic risk factors appear to play a role in OA pathogenesis. However, few human studies have studied the association between dietary factors and risk of future knee OA development. We have preliminary data from the Osteoarthritis Initiative (OAI), a large cohort with repeated measures of OA symptoms and radiographic outcomes, demonstrating that the Western dietary pattern, characterized by high intakes of red/ processed meats, refined grains, desserts / sweets, was associated with increased risk of radiographic knee OA. In contrast, the Prudent dietary pattern characterized by high intakes of fruits/ vegetables, legumes, whole grains, poultry, and fish was associated with reduced risk of knee OA. Hence, adherence to a healthy diet may provide a potential strategy for the prevention of knee OA. However, self-report dietary assessment methods, such as food-frequency questionnaires (FFQs) and diet records, may be subject to recall bias and measurement error. Biomarkers of dietary intake taking into account the nutrient bioavailability and metabolism may better represent a long-term nutritional status. Recently, metabolomics, by measuring a large number of downstream components or metabolic products (metabolites), provides the most integrated profile of biological status reflecting environmental, dietary and genetic interactions, and therefore may more precisely define dietary exposures and provide better estimates of disease risk in epidemiologic studies. To date, intervention studies have identified a variety of metabolites related to the dietary intake of major foods. More than 50 of them have been validated by multiple studies. To date, no study has ever assessed the association between metabolites of dietary intake and future risk of knee OA. We propose a nested case-control study in OAI cohort including 261 incident knee OA cases and 261 matched controls to examine whether individual metabolites and metabolomic profiles of dietary intake predict subsequent risk of development of knee OA, and whether diet-related metabolites and metabolomic profiles influence imaging biomarkers of knee OA. Finally, we will examine whether imaging biomarkers of knee OA mediate the associations of diet-related metabolomic profiles with risk of knee OA. This study will help to identify dietary factors associated with knee OA development, and offer the potential for effective OA prevention strategies; therefore, it may have large public health and clinical implications.

项目摘要 /摘要骨关节炎（OA）是关节炎的最常见形式，是活动限制和老年人的身体残疾。在没有疾病修饰疗法的情况下，迫切需要有效，可用的方法有助于预防和管理这种常见条件。与炎症，肥胖和其他代谢危险因素相关的饮食因素似乎在 OA发病机理。但是，很少有人类研究研究饮食因素之间的关联和未来膝盖OA发育的风险。我们拥有骨关节炎倡议（OAI）的初步数据，A 大型队列，重复衡量OA症状和射线照相结果，表明西方饮食模式，其特征是高度摄入红色 /加工肉，精制谷物，甜点 / 糖果与射线照相膝关节OA的风险增加有关。相反，审慎的饮食方式以高摄入量的水果/蔬菜，豆类，全谷物，家禽和鱼类为特征膝盖OA的风险降低。因此，遵守健康饮食可能会为预防膝盖OA。但是，自我报告的饮食评估方法，例如食物频率问卷（FFQS）和饮食记录可能会召回偏见和测量误差。生物标志物考虑到营养生物利用度和代谢可能会更好地代表长期的饮食摄入量营养状况。最近，代谢组学通过测量大量下游组件或代谢产物（代谢产物），提供了反映生物状态最集成的概况环境，饮食和遗传相互作用，因此可以更精确地定义饮食暴露并在流行病学研究中更好地估计疾病风险。迄今为止，干预研究已有鉴定出与主要食物饮食摄入有关的各种代谢产物。其中有50多个通过多个研究验证。迄今为止，尚未评估代谢物之间的关联饮食摄入量和膝盖OA的未来风险。我们在OAI队列中提出了一项嵌套的病例对照研究包括261例膝盖OA病例和261个匹配的对照，以检查是否单个代谢物饮食摄入量的代谢组概况可以预测随后的膝盖发育风险，以及是否是否与饮食相关的代谢产物和代谢组谱影响膝关节OA的成像生物标志物。最后，我们会的检查成像膝关节的生物标志物是否介导与饮食相关的代谢组谱的关联有膝盖OA的风险。这项研究将有助于确定与膝关节发育相关的饮食因素，以及提供有效的OA预防策略的潜力；因此，它可能具有庞大的公共卫生和临床含义。