Metabolites of Dietary Intake and Risk of Knee Osteoarthritis

膳食摄入代谢物与膝骨关节炎的风险

• 批准号: 9815151
• 负责人: Bing Lu
• 金额: $ 70.54万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-05 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9815151
• 关键词: Ache; Adherence; Ancillary Study; Arthritis; Awareness; Biological; Biomarker of Dietary Intake; Blood specimen; Bone Marrow; Cartilage; Clinical; Consumption; Data; Degenerative polyarthritis; Development; Diagnostic radiologic examination; Diet; Diet Records; Dietary Assessment; Dietary Factors; Dietary Fiber; Dietary Practices; Dietary intake; Disease; Domestic Fowls; Fabaceae; Fasting; Fatty acid glycerol esters; Fishes; Food; Frequencies; Future; Genetic; Grain; Human; Incidence; Individual; Inflammation; Intake; Intervention Studies; Kellgren-Lawrence grade; Knee Osteoarthritis; Lesion; Mass Fragmentography; Measurement; Measures; Mediating; Memory; Metabolic; Methods; Milk; Nested Case-Control Study; Nutritional status; Nutritive Value; Obesity; Outcome; Pain; Pathogenesis; Patient Self-Report; Pattern; Physically Handicapped; Play; Prevention; Prevention strategy; Principal Component Analysis; Processed Meats; Prognostic Marker; Proteins; Public Health; Questionnaires; Reporting; Risk; Risk Factors; Role; Symptoms; Technology; Unsaturated Fats; base; cohort; disorder risk; effusion; epidemiology study; fruits and vegetables; good diet; imaging biomarker; magnetic resonance imaging biomarker; metabolome; metabolomics; nutrient metabolism; prognostic; saturated fat; willingness

PROJECT SUMMARY / ABSTRACT Osteoarthritis (OA) is the most common form of arthritis and the major cause of activity limitation and physical disability in older people. In the absence of disease modifying therapy, there is an urgent need for effective, widely available approaches to aid in the prevention and management of this common condition. Dietary factors associated with inflammation, obesity and other metabolic risk factors appear to play a role in OA pathogenesis. However, few human studies have studied the association between dietary factors and risk of future knee OA development. We have preliminary data from the Osteoarthritis Initiative (OAI), a large cohort with repeated measures of OA symptoms and radiographic outcomes, demonstrating that the Western dietary pattern, characterized by high intakes of red/ processed meats, refined grains, desserts / sweets, was associated with increased risk of radiographic knee OA. In contrast, the Prudent dietary pattern characterized by high intakes of fruits/ vegetables, legumes, whole grains, poultry, and fish was associated with reduced risk of knee OA. Hence, adherence to a healthy diet may provide a potential strategy for the prevention of knee OA. However, self-report dietary assessment methods, such as food-frequency questionnaires (FFQs) and diet records, may be subject to recall bias and measurement error. Biomarkers of dietary intake taking into account the nutrient bioavailability and metabolism may better represent a long-term nutritional status. Recently, metabolomics, by measuring a large number of downstream components or metabolic products (metabolites), provides the most integrated profile of biological status reflecting environmental, dietary and genetic interactions, and therefore may more precisely define dietary exposures and provide better estimates of disease risk in epidemiologic studies. To date, intervention studies have identified a variety of metabolites related to the dietary intake of major foods. More than 50 of them have been validated by multiple studies. To date, no study has ever assessed the association between metabolites of dietary intake and future risk of knee OA. We propose a nested case-control study in OAI cohort including 261 incident knee OA cases and 261 matched controls to examine whether individual metabolites and metabolomic profiles of dietary intake predict subsequent risk of development of knee OA, and whether diet-related metabolites and metabolomic profiles influence imaging biomarkers of knee OA. Finally, we will examine whether imaging biomarkers of knee OA mediate the associations of diet-related metabolomic profiles with risk of knee OA. This study will help to identify dietary factors associated with knee OA development, and offer the potential for effective OA prevention strategies; therefore, it may have large public health and clinical implications.

项目概要/摘要 骨关节炎 (OA) 是最常见的关节炎形式，也是活动受限和活动受限的主要原因。 老年人的身体残疾。在缺乏疾病修饰疗法的情况下，迫切需要 有效、广泛使用的方法有助于预防和管理这一常见病症。 与炎症、肥胖和其他代谢危险因素相关的饮食因素似乎在 OA发病机制。然而，很少有人类研究研究饮食因素之间的关联 以及未来发生膝关节骨关节炎的风险。我们有来自骨关节炎倡议 (OAI) 的初步数据， 重复测量 OA 症状和放射学结果的大型队列，表明 西方饮食模式，特点是大量摄入红肉/加工肉类、精制谷物、甜点/ 甜食与放射学膝关节 OA 的风险增加有关。相比之下，谨慎的饮食模式 其特征是大量摄入水果/蔬菜、豆类、全谷物、家禽和鱼类 降低膝关节 OA 的风险。因此，坚持健康饮食可能为以下方面提供潜在的策略： 预防膝关节骨关节炎。然而，自我报告的饮食评估方法，例如食物频率 调查问卷（FFQ）和饮食记录可能会受到回忆偏差和测量误差的影响。生物标志物 考虑到营养物质生物利用度和代谢的膳食摄入量可能更好地代表长期 营养状况。最近，代谢组学通过测量大量下游成分或 代谢产物（代谢物），提供反映生物状态的最综合概况 环境、饮食和遗传相互作用，因此可以更准确地定义饮食暴露 并在流行病学研究中提供更好的疾病风险估计。迄今为止，干预研究已 确定了与主要食物的膳食摄入相关的多种代谢物。其中超过50人已被 经多项研究验证。迄今为止，还没有研究评估代谢物之间的关联 饮食摄入量和未来膝关节骨关节炎的风险。我们建议在 OAI 队列中进行一项巢式病例对照研究 包括 261 例膝关节 OA 病例和 261 例匹配对照，以检查个体代谢物是否 膳食摄入量和代谢组学特征可预测随后发生膝关节 OA 的风险，以及是否 饮食相关的代谢物和代谢组学特征影响膝关节骨关节炎的成像生物标志物。最后，我们将 检查膝关节 OA 的影像生物标志物是否介导饮食相关代谢组学特征的关联 有膝关节 OA 的风险。这项研究将有助于确定与膝关节 OA 发展相关的饮食因素，以及 提供有效 OA 预防策略的潜力；因此，它可能具有重大的公共卫生和临床意义 影响。