DOSE EFFECTS OF DIETARY PHYTOSTEROLS ON CHOLESTEROL METABOLISM: A CONTROLLED

膳食植物甾醇对胆固醇代谢的剂量效应：对照

• 批准号: 8361452
• 负责人: RICHARD E. OSTLUND
• 金额: $ 1.08万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361452
• 关键词: Adult; Beverages; Cholesterol; Cholesterol Homeostasis; Diet; Dose; Eating; Education; Excretory function; Funding; Grant; Intake; Intestines; LDL Cholesterol Lipoproteins; Lipoproteins; Mass Spectrum Analysis; Measures; Metabolic; National Center for Research Resources; Phytosterols; Placebo Control; Principal Investigator; Research; Research Infrastructure; Resources; Serum; Site; Source; Supplementation; Tracer; United States National Institutes of Health; biomedical resource; cholesterol absorption; cost; feeding; primary outcome; programs; stable isotope

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. BACKGROUND: Phytosterol supplementation of 2 g/d is recommended by the National Cholesterol Education Program to reduce LDL cholesterol. However, the effects of different intakes of phytosterol on cholesterol metabolism are uncertain. OBJECTIVE: We evaluated the effects of 3 phytosterol intakes on whole-body cholesterol metabolism. DESIGN: In this placebo-controlled, crossover feeding trial, 18 adults received a phytosterol-deficient diet (50 mg phytosterols/2000 kcal) plus beverages supplemented with 0, 400, or 2000 mg phytosterols/d for 4 wk each, in random order. All meals were prepared in a metabolic kitchen; breakfast and dinner on weekdays were eaten on site. Primary outcomes were fecal cholesterol excretion and intestinal cholesterol absorption measured with stable-isotope tracers and serum lipoprotein concentrations.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 背景：国家胆固醇教育计划推荐植物固醇补充2 g/d，以减少LDL胆固醇。然而，植物醇不同摄入量对胆固醇代谢的影响尚不确定。 目的：我们评估了3种植物醇摄入量对全身胆固醇代谢的影响。 设计：在这项安慰剂对照的跨界喂养试验中，有18名成年人接受了植物醇不足的饮食（50 mg植物固醇/2000 kcal）加上补充0、400或2000 mg植物醇/d的饮料，分别在4周。所有饭菜都是在代谢厨房准备的。工作日的早餐和晚餐在现场吃。主要结果是用稳定的异位素示踪剂和血清脂蛋白浓度测量的粪便胆固醇排泄和肠道胆固醇吸收。